Drug-Induced Liver Injury (DILI) is often accompanied by immunological features indicating either hypersensitivity or an autoimmune reaction or both. a number of common mechanisms of liver toxicity;
Serious infections are a risk with use of these biologic agents. Adalimumab, certolizumab, efalizumab, etanercept, golimumab, and infliximab have black box warnings to this effect. Tuberculosis (TB)
Autoimmune disease mechanisms; T cells and B cells activation in Rheumatoid Arthritis (RA) & Systemic Lupus.
The underlying basic mechanisms of autoimmune reactivity have been puzzling immunologists for decades. What makes the immune system turn against the organism itself? immunology investigation.