von Willebrand's Disease in Dogs

Bleeding Disorders in Dogs

The author's Golden Retriever has type I vWD. Fortunately, this form of the clotting disorder is fairly mild.
The author's Golden Retriever has type I vWD. Fortunately, this form of the clotting disorder is fairly mild. | Source

Clotting Disorders in Dogs

There are many factors that affect how well blood clots. If a dog is missing any one of these crucial factors, a clotting disorder will develop. Dogs with clotting disorders will bleed more than a typical dog, and may have life-threatening bleeds during routine surgeries, like neutering.

The most common clotting disorder in dogs is called von Willebrand's Disease, which is often detected by a common screening tests at the veterinarian's office (the so-called gum prick test). During surgery, the animal may bleed profusely, triggering suspicion of von Willebrand's Disease (vWD). Some breeds are more likely to have vWD and will be tested specifically for the problem by their breeder.

What is von Willebrand's Disease?

Animals who do not have a normal level of von Willebrand's Factor (vWF) will not form blood clots in a normal time frame. vWF is crucial for normal platelet function, and the lack of vWF will prevent platelets from aggregating properly at a wound site.

von Willebrand Factor is made by the epithelium lining the blood vessels. It acts as a "glue" to bind platelets to the site of the wound. When a dog doesn't have a normal level of vWF, the platelets cannot bind to the broken blood vessel walls, which causes prolonged bleeding.

Mucosal Bleed Test in Dogs

A screening test for clotting disorders involves pricking the dog's gums and noting the time until clot formation.
A screening test for clotting disorders involves pricking the dog's gums and noting the time until clot formation. | Source

Symptoms of von Willebrand's Disease in Dogs

Fortunately, most dogs have a mild presentation of von Willebrand's. This means that the bleeding disorder will rarely cause problems, and your pet will likely have a full life. Some forms of von Willebrand's are more severe and these dogs require specialized care. Symptoms of von Willebrand's Disease in dogs are:

  • Nose bleeds
  • Bleeding from the gums
  • Heavy bleeding when in heat
  • Excessive blood when teething
  • Excessive bleeding from surgery or trauma
  • Blood in the urine or stool

Testing for Canine vWD

Most dogs are screened for clotting disorders prior to surgery. A test known as the mucosal bleeding test is generally performed before spay and neuter operations. The vet will prick the gum of the dog and the time to clot formation is noted. Dogs with a prolonged clotting time may have one of several disorders, including von Willebrand's.

There are two specific tests for vWD: one is a genetic test, and the other measures activity of vW Factor in the blood. Veterinarians can order both tests.

von Willebrand's Factor and Platelets

How do Dogs get von Willebrand's?

von Willebrand's Disease is a hereditary clotting disorder, where levels of von Willebrand's Factor are less than 60% of normal. There are three types of vWD in dogs: the first type tends to be mild, and the last two types are severe.

Type I vWD: occurs in many breeds, and the dogs have a reduced level of von Willebrand's Factor. The severity of the bleeding increases as the level of vWF decreases. This type is inherited as an "incomplete dominant," meaning that puppies will inherit it from their affected parent, but the degree will vary depending on how much of the gene is expressed. Two pups from the same litter may have dramatically different levels of vWF. This type is the most mild type, and most dogs live a full life. If both parents have the vWF gene, puppies who inherit both copies of the gene will be stillborn or die shortly after birth.

Type II vWD: This type is extremely severe and causes profuse bleeds in affected dogs. This type of vWD is not caused by a low level of von Willebrand's Factor, but by an abnormally functioning factor. This type of vWD is seen in the pointer breeds. This is the rarest of the vWD types.

Type III vWD: This type is also rare and extremely severe. These dogs do not have any von Willebrand's Factor at all. This type of von Willebrand's is autosomal recessive, so carriers of the disorder will not display any type of bleeding disorder at all. 25% of the puppies will inherit the bleeding disorder (getting both copies of the gene). Up to 10% of Scottish Terriers carry this gene, making the disorder a serious problem for breeders.

Dog Breeds with von Willebrand's Disease

Click thumbnail to view full-size
German Short-Haired Pointers are sometimes affected by the extremely rare Type II vWD.Scottish Terriers are prone to Type III vWD, but may also be affected by Type I.Doberman Pinschers are prone to Type I vWD.Shetland Sheep Dogs are sometimes affected by vWD Type III.Sporadic cases of vWD Type III have been reported for the Chesapeake Bay Retriever.
German Short-Haired Pointers are sometimes affected by the extremely rare Type II vWD.
German Short-Haired Pointers are sometimes affected by the extremely rare Type II vWD. | Source
Scottish Terriers are prone to Type III vWD, but may also be affected by Type I.
Scottish Terriers are prone to Type III vWD, but may also be affected by Type I. | Source
Doberman Pinschers are prone to Type I vWD.
Doberman Pinschers are prone to Type I vWD. | Source
Shetland Sheep Dogs are sometimes affected by vWD Type III.
Shetland Sheep Dogs are sometimes affected by vWD Type III. | Source
Sporadic cases of vWD Type III have been reported for the Chesapeake Bay Retriever.
Sporadic cases of vWD Type III have been reported for the Chesapeake Bay Retriever. | Source

Dog Breeds with vWD

Many dog breeds are affected by Type I vWD, the mildest version of the disease. Affected breeds include:

  • Doberman Pinscher
  • Golden Retriever
  • Poodles
  • Corgis
  • Miniature Schnauzers
  • Scottish Terriers
  • Dachshunds
  • Shetland Sheep Dogs
  • Basset Hounds
  • Rottweilers
  • German Shepherds
  • Keeshonds
  • Mixed Breeds

Type II vWD is extremely rare, and has been observed in the German Short-Haired Pointer.

Type III vWD is also rare and has been reported in the Scottish Terrier, Shetlands, and (rarely) in Chesapeake Bay Retrievers.

Precautions for Dogs with vWD

Aggressive play should be kept to a minimum. Visits to the dog park, for example, could be dangerous for a dog with von Willebrand's. If another animal bites or otherwise injures the dog, profuse bleeding could result.

All dogs should undergo a clotting screening prior to surgery, and breeds with a known predisposition to the more severe forms of vWD should have genetic testing performed. Any dog with a known clotting disorder should receive prophylactic treatment before any surgery is considered.

Treatment for Canine von Willebrand's

There is no cure for von Willebrand's, but appropriate steps may be taken to ensure the animal is kept as healthy as possible. Transfusions of vWF are possible for dogs with a more severe form of the disorder (or for dogs who have recently undergone trauma).

For dogs with known vWD, an elective transfusion may be given prior to any surgery to ensure the dog does not bleed excessively during the procedure. Many dogs who have vWD also have a low thyroid hormone level. Dogs with von Willebrand's should have their thyroid level tested and treated, if low, to help improve blood clotting ability.

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Comments 4 comments

lindacee profile image

lindacee 4 years ago from Southern Arizona

Leah, I've heard of this disease but didn't know a thing about it. What a terrible fate for a dog. I have to wonder if inbreeding and puppy mills contribute to this disorder. I'm am so sorry your Golden has van Willebrand's. Thankfully it is not the severe type. I love the photo! Hope all is well.


teaches12345 profile image

teaches12345 4 years ago

So sorry for your dog, but I guess the mild type is much easier to handle. I didn't know this disease existed in dogs. Great hub and I am sure it will be helpful to pet owners.


leahlefler profile image

leahlefler 4 years ago from Western New York Author

Lindacee, inbreeding definitely affects the last two types (types II and III), which are recessive in nature. The first type is incomplete dominant and is seen in every breed of dog (including mixed breeds), so inbreeding isn't as much of an issue with that type. If you breed two dogs with Type I together, though, some puppies will get a double dose of the gene, which is fatal.


leahlefler profile image

leahlefler 4 years ago from Western New York Author

Teaches12345, we were a bit shocked when they told us Casey had it. He was neutered at the age of six months and they kept him for 2 days, but never said there was a complication. When we brought him back for his annual check-up and shots, the vet said, "Oh, he looks great. Be careful with heavy exercise because of the von Willebrand's!" I was shocked!

She felt bad that we had no idea he had it - they were supposed to tell us when we picked him up from his neuter. It is a good thing to know, as when he stays in the dog kennel he gets his own pen and is not allowed to play with other dogs in the yard, in case he gets hurt. They do let him play with another (older) golden retriever who is very gentle. Fortunately, he has the mild type and will have a normal, happy life.

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