Depending on your interests you can work in an office or at home. At this point in time, I feel comfortable working in an office where greater interaction with others is involved; the interaction also comes with occasional field trips that you may be assigned to undertake (since I love travelling, that is definitely a plus). Once I have a family life of my own with children to cater to, I might be inclined to work from home.
Also, juggling multiple careers at a single time may be difficult for someone stuck in a location miles away from the next destination he is supposed to be at.
If you look at freelancers, they undertake multiple jobs while enjoying homelife. it is all a matter of choice. :)