Well Saint, I really cant answer that question. As I just started using it yesterday. I for one had a bad experience with adsense, and unfortunately the only to remove most of their ads from you hubs is by adding Amazon, or some other. How ever if you go to Amazon website they explain it quite well it is biased on percentage of the sale I believe. like you start at 6% and can make as much as 15% or something like that. Im not clear on if they have to buy the item they click on or another but they call it referral %s so maybe so. Anyways, I guess I need to look into it better maybe in the future I can explain the success of it better. But I am pretty sure you can run both. you dont have to put as many Amazon ads as I did, I only did that to cut out adsense ads. sorry I know that doesn't help you much. I hope you find your answer. because if you click the tab that says it doesnt agree with google adsense it wont publish the hub.I wish I know how to get their crap totally off of my hubs I guess aside from starting my own website I can't do much about it except run Amazon in their place. I was thinking of trying the other one also, Kontera I think its called.