It has more to do with the *way* you respond when you do respond than if you are responding at all. It depends upon the type of hub that is written. Some product hubs do not have comment capsules at all. So far, I do respond to all comments individually. I may come to a point where I receive so many, I can only give a group thank-you. But to respond to some individually but ignore others when all are asking questions is where there gets to be a problem.
There is a difference between ignoring all of people's comments because you get hundreds per day vs. ignoring them because you are randomly picking out comments for responses instead of responding to them all.
Another thing that makes a difference is the tone of your response. It is better to not respond to someone than to tell the person off with swear words, for example.