I agree with many of the other answers; I'm going to say yes and no. It is true that other hubbers are more likely to comment than other web visitors, and that having most of your traffic come from inside hubpages is great for views but not necessarily click-throughs and purchases. So it depends what your measure of success is for a hub as well--for me, it's how well the traffic converts into revenue.
However, it seems that having more comments does improve your hub's score, which I believe also helps boost you in the rankings with google somehow (though I'm not entirely sure...I *think* I read that somewhere but you may want to double check on this 'fact'). Similarly, other hubbers who comment are mostly doing so in a positive way and will also often vote your hub up and interesting (etc.) while they're there, which helps that hubscore as well.
So on the one hand, don't be sad for a hub that has no comments; it can still perform well in google and bring in lots of traffic if it has the right elements. On the other hand, I don't think a hub that has lots of comments would be hurt by the fact that it does!