Laugh. I am guessing you wrote something someone found offensive and now a bunch of people are commenting? The thing about that is if you wrote something you knew would be controversial or a hot button issue just realize the negative comments mean you got someone's attention! You're just doing your job at that point. You cannot change their minds or behavior so just shake your head in pity and laugh at their obvious lack of intellectual facilities. I wrote a whole article about negative comments, Sometimes Hatemail is Fun, perhaps you'd find out how to get this mind set from it.
If you are talking about in real life... well... just know there will always be far more frustrating individuals than not. Find some who are not and relish their company when you have it. This is the key to sanity in an increasingly numb world. Best wishes to you.
PS by responding in a cordial emotionally stable manner you are showing you are the better person. This probably annoys the badly behaved and definitely makes you look good to people reading the comments! Cheers!