6 Facts about Heart Attack

Acute MI-Pain Distribution-Chest

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Myocardial Infarction (Heart Attack) - Introduction

Myocardial Infarction (Heart Attack) results from the acute occlusion of one of the coronary arteries causing death/necrosis of myocardium supplied by that particular vessel. When the blood vessel is occluded it may result in complete deprivation of blood supply to the area.

Coronary arteries are the blood vessels supplying the heart.

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1. How do we get Pain in Myocardial Infarction?

When the blood supply to the myocardium is deprived, it will result in inadequate oxygen to the myocardium and the myocardial tissue dies.

  • The inadequate blood supply or in other terms, ischemia can activate anaerobic metabolism because of the lack of oxygen.

  • Anaerobic metabolism produces lactate which irritates the nerve endings in the myocardium.

  • Patient experiences retrosternal chest pain and the pain may radiate to neck, jaw, left shoulder and anterior aspect of forearm.

  • Pain of Myocardial infarction is very severe and usually lasts for more than 30 min.

Heart-Inferior wall Infarct

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Heart Attack-Pain Distribution-Back

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2. Factors contributing to the development of Myocardial Infarction

Certain non-modifiable risk factors contributing to the development of Myocardial Infarction are

  • Age – Men and women who are older are 50 years of age more likely to get Myocardial Infarction than younger people

  • Sex- Males are more at risk than females

  • Family historyof premature coronary artery disease–Family history is another risk factor which cannot be modified

Modifiable risk factors include

  • Diabetes

  • Tobacco usage

  • Hypercholesterolemia

  • High blood pressure

  • Obesity

  • Stress

  • Lack of physical activity

3. Cause for Myocardial Infarction

Atherosclerosis or deposition of fat within the wall of the blood vessels supplying the heart is the most important cause for the development of Myocardial Infarction. Deposition of fat streaks within the blood vessel wall will reduce the lumen of the vessel wall and reduce the blood supply. Many changes like fissuring and ulceration can occur to the fatty plaque. This results in fatty core of the plaque coming in contact with blood and as a result the development of thrombus starts. Thrombus formation further reduces the blood supply to the myocardium.

Intracoronary thrombus removed from a coronary artery during a percutaneous coronary intervention to abort a myocardial infarction. Five pieces of thrombus are

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4. TYPES OF MI and the changes in ECG leads in each type

Myocardial Infarction affects the different areas of the heart depending on which blood vessel is occluded.

¨ Anterior wall- V3 &V4

¨ Lateral Wall-1, aVL, V5, V6

¨ Inferior wall-II, III, aVF

¨ Septum-V1 & V2

Heart-Posterior wall infarct with VSD

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5. Symptoms of Myocardial Infarction

  • Pain –Pain of myocardial infarction is severe lasting more than 30 minutes. Usually pain is felt substernally or retrosternally (behind the sternum). Pain may also radiate to the jaw, shoulder and arm.

There may also be associated discomforts like

  • Difficulty in breathing

  • Pallor

  • Nausea, vomiting

  • Fatigue

  • Increased heart rate and fall in blood pressure

  • Excessive sweating

6. Management of Myocardial Infarction

The first aim of treating MI is to restore blood supply (perfusion) to the damaged myocardium.

The treatment can be different in to the phases like

Pre hospital care

  • Alert the emergency department

  • Oxygen administration

  • ECG and Pulse oximetry monitoring

  • Nitroglycerin sublingual

  • Aspirin

  • Establish an IV line

  • Transport the patient to the emergency room as early as possible

Management at the emergency department

  • Continue with supplemental oxygen, pulse oximetry and ECG monitoring

  • Nitroglycerin may need to be continued; observe for hypotension, bradycardia

  • Intractable pain is treated with Morphine

  • Differentiate between STEMI, NSTEMI or Unstable Angina and treatment to be initiated accordingly (thrombolysisVs. PCI)

In-Hospital treatment

The aim is to observe, minimize the damage to the myocardium and to recanalise the affected arteries.

Patient may be given beta blockers, morphine, aspirin, nitroglycerin and statins to reduce cholestrolemia. Depending on the need patient may be taken for PCI or CABG.

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Comments 12 comments

thumbi7 profile image

thumbi7 16 months ago from India Author

Hi Alicia C

Thanks for the visit and comment


AliciaC profile image

AliciaC 16 months ago from British Columbia, Canada

This is a very informative and useful hub. Thank you for sharing the information.


thumbi7 profile image

thumbi7 2 years ago from India Author

Hi thebiologyofleah

Thank you so much for visiting this page. I truly appreciate it

I am glad that you found this article interesting


thebiologyofleah profile image

thebiologyofleah 2 years ago from Massachusetts

Great information here and it was easy to follow with the inclusion of images and videos. I come across a lot of heart pathology in my work and I am always trying to understand it more. Thanks!


thumbi7 profile image

thumbi7 3 years ago from India Author

Hi DDE,

Thanks for the visit


DDE profile image

DDE 3 years ago from Dubrovnik, Croatia

You always manage to inform us on such helpful health information, a useful and informative hub indeed. The diagrams and photos help with the explanations of this hub.


thumbi7 profile image

thumbi7 3 years ago from India Author

Hi MG Singh,

I am glad that you liked this hub. Take care


thumbi7 profile image

thumbi7 3 years ago from India Author

Hi Nell Rose,

Thanks for the comment and vote


Nell Rose profile image

Nell Rose 3 years ago from England

Hi thumbi, this was a really detailed and fascinating look at this illness, voted up and shared, nell


thumbi7 profile image

thumbi7 3 years ago from India Author

Hi Mary,

Sorry to hear about your loss. I hope your good health continues...

Take care


MG Singh profile image

MG Singh 3 years ago from Singapore

Informative hub


mary615 profile image

mary615 3 years ago from Florida

I lost my mother, father, and a brother to heart attacks. I have had no problems yet, and hope I don't.

You wrote a very informative Hub here; researched well.

Voted UP and will share.

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