Larry's Take on the Aspartame Debate

Aspartame is a sweetener commonly used in 'diet' soda.
Aspartame is a sweetener commonly used in 'diet' soda. | Source

A sample size of one

Yuck! How can anyone drink this junk?

That was what I thought the last time someone offered me a 'diet' soda sweetened with Aspartame. To me, Aspartame tastes mostly bitter. If I put an entire packet of the stuff on my tongue, there will be a sweet taste that lasts for about 2 seconds, before the bitterness kicks in. However many years ago, Aspartame did taste sweet.

Perhaps the change in my taste perception is a part of the aging process. I also have Dysfunctional Sensory Integration, which includes sensory defensiveness. Some sensory experiences that are ho-hum for most people cause considerable discomfort for me. For example, the noise of a washing machine is somewhat painful to me, as are the fluorescent lights in the local supermarket. Because of the DSI, I suspect that Aspartame has a bigger impact on me than it does for most people.

I have experimented with Aspartame. As little as 4 packets can cause discomfort. I suspect that it's because of phenylalanine. We'll have another look at this amino acid in a later section.

Those who claim that Aspartame has been 'scientifically proven' to be safe for human consumption are overstating their case. Take water. Everyone agrees that it's necessary for life.

Here's a thought experiment: Parachute into the middle of Lake Michigan just after the last ice has melted, with no supplies, and wearing only swim trunks. Do you still believe that water is absolutely safe for everyone, in all quantities, and under all circumstances.

In light of the thought experiment, there are a few questions that reasonable people could ask about Aspartame.

• What are the real risks of Aspartame?

• In order to keep these risks within acceptable limits, what's a reasonable dose?

• And who should avoid Aspartame?

On the other hand, there are some wild alarmist claims about Aspartame floating around in the Blogosphere. For reasons that I do not fully understand, Aspartame has become a lightning rod for conspiracy buffs. But as the late Carl Sagan famously said in another context,

"Extraordinary claims require extraordinary evidence."

That extraordinary evidence does not exist. Aspartame is a mixed bag. And it's not productive to go into a tizzy over Aspartame. Instead, let's look at the known facts.


Overview of artificial sweeteners

The granddaddy of all artificial sweeteners was lead(II) acetate. Yes, that's lead, as in lead poisoning. I'm reminded of the expression, "a taste to die for."

Saccharin was accidentally discovered in the late 19th Century. Saccharin achieved significant market penetration during World War I, when sugar prices were quite high. Consumers saved money by substituting Saccharin for sugar in their coffee or tea.

In the late 1930s, Cyclamate, like Saccharin before it, was discovered by accident. To a certain extent, the yucky off-tastes of Saccharin and Cyclamate cancel each other out.

In rat experiments, the animals developed bladder cancer when fed extremely high doses of Cyclamate. Was it prudent to ban cyclamate in the USA? I don't know.

Aspartame was discovered in the 1960s--again accidentally. When it was commercially introduced, Aspartame ignited a firestorm of controversy. That may have had something to do with the aggressive way that Aspartame--aka NutraSweet at the time--was pushed through the FDA approval process. Thanks to an urban legend that refuses to die, this sweetener remains controversial even in the early 21st Century.

Neotame is somewhat similar to aspartame. The practical difference is that during digestion phenylalanine is released at a considerably slower rate than for Aspartame. This makes Neotame less hazardous for children with PKU. We'll go into more detail about phenylalanine and PKU in a later section.

More recently, Sucralose--aka Splenda--has become available. To my refined taste buds, it's the only artificial sweetener that actually tastes sweet, and does not leave a strange aftertaste.

We'll see why artificial sweeteners do not help overweight people lose body fat. But first, let's have a closer look at 'evil' Aspartame.


Aspartame
Aspartame | Source
Paracelsus
Paracelsus | Source

What do we know about Aspartame?

Aspartame is a methyl ester of a dipeptide (a molecule comprising two amino acids). The moieties that comprise the dipeptide are aspartic acid and phenylalanine. After we ingest Aspartame, the molecule is quickly broken down into these two amino acids plus methyl alcohol, aka methanol.

At first blush, the methanol aspect appears to be a cause for concern. Excessive doses of methanol can cause blindness, or even death. The key phrase is "excessive doses."

Let's put that into perspective. Like Aspartame, apples contain a methyl ester, methyl butyrate. But for some reason, there aren't nearly as many anti-apple alarmists as there are anti-Aspartame alarmists.

Extremely high concentrations of aspartic acid can lead to excitotoxicity and death of certain brain cells. The key phrase is "extremely high concentrations."

The non-essential amino acid, aspartic acid is a constituent of many proteins in foods commonly eaten by humans. Should we demonize these foods as well?

Unlike aspartic acid, phenylalanine is an essential amino acid. If you made a concerted effort to avoid ALL dietary phenylalanine, you'd need to avoid ALL protein, even the small concentrations found in corn, rice, and potatoes. And the protein deficiency would kill you.

Because of the phenylalanine, children who have PKU (phenylketonuria) should not be allowed to eat desserts sweetened with Aspartame, or to consume soft drinks containing Aspartame, without permission from their pediatrician.

With respect to all three chemicals--methanol, aspartic acid, and phenylalanine--we should remember an old saying by Paracelsus:

"The dose makes the poison."

I've explored the limitations and range of applicability for Paracelsus' meme in an earlier hub about allegedly 'evil chemicals'.

More importantly, the unproductive Aspartame debate glosses over a larger issue.


Can artificial sweeteners help you to slim down?

There's precious little evidence to support that claim. And there's reason to suspect that they may have the exact opposite effect. Why?

A sweet taste triggers an insulin response, which is appropriate when you've just eaten a piece of fruit or a conventional dessert. High blood sugar levels are unhealthful. The extra insulin encourages the extra glucose to go into the cells, including fat cells.

Here's my speculation about a different scenario. In between meals, you're thirsty, and drink a can of 'diet' soda, containing Aspartame or some other artificial sweetener. This causes an interesting chain of events.

Initially, the sweet taste triggers an insulin response. This causes your blood sugar to decrease, which can make you hungrier than you'd otherwise be. If your blood sugar was marginal to begin with, you may choose to have a snack that you wouldn't otherwise need, in order to chase away the 'hongries'. In the short run, artificial sweeteners can contribute to overeating.

In the longer run, the daily consumption of artificial sweeteners can blunt your body's natural response to fresh fruit and other sweet-tasting food. After eating that yummy pear, your blood sugar will now spike at a concentration that's within the slightly unhealthful range.

Some animal studies are consistent with my hypothesis about downregulation. One study of human volunteers found an association between 'diet' soda consumption and overweight. Here's a link to that WebMD article. However this is not a conversation-stopper.

Correlation is not the same as causation. Does the 'diet' soda cause people to get fat? Or does obesity cause people to feel guilty, and to consumer more 'diet' soda? Or do the two things have a common cause?

Another human study does not show any effect. If I've understood correctly, sucralose was injected directly into the GI tract. This prevented the volunteers from experiencing the taste of this particular artificial sweetener.

Surprise, surprise! No insulin response. The study answered an obvious question, and was a small step in the advancement of scientific knowledge. However the study also has the potential to be used as pro-artificial sweetener industry propaganda.

I'd like to add a caveat to my Downregulation Hypothesis. If one never ever eats or drinks anything that contains sugar--and yes that includes sweet fruit--then 'diet' soda should have a smaller impact on one's efforts to slim down.

*dry humor on*
However in this case, I'd advise wolfing down one's starchy food as quickly as possible. The enzyme ptyalin in saliva begins to digest the starch before the food is even swallowed. The sugar glucose is the result of starch digestion, and after considerable chewing, the glucose will impart a slightly sweet taste to the rice or potato that one is noshing on. But that's a small price to pay for the passionate purple pleasure of drinking a can of Diet Coke every afternoon.
*dry humor off*


What about cancer?

Most studies fail to show a link between Aspartame and cancer. On the other side, there are some dodgy European studies from the Ramazzini Foundation, in which the researchers were reluctant to share important raw data. This is a red flag in and of itself. For other reasons as well, these 'advocacy science' studies do not pass the smell test. But don't take my word for it. Here's a link to the relevant section of the long Wikipedia article on the Aspartame controversy.

Shades of Global Warming 'science'.


Michael J Fox
Michael J Fox | Source

What about the phenylalanine?

Inside our digestive tracts, Aspartame is quickly broken down into it's three basic components: phenylalanine, aspartic acid, and methanol.

Phenylalanine can cross the blood-brain barrier. The body uses it as a starting material to make the catecholamines: epinephrine, norepinephrine, and dopamine. Catecholamines are necessary for normal brain functioning. Parkinson's Disease patients, like actor Michael J Fox, have insufficient dopamine activity in their brains. You'd be dead without catecholamines in your brain.

As I mentioned earlier, you'd also be dead if your diet contained zero phenylalanine, because it's an essential amino acid. Fortunately for us, phenylalanine is found not only in foods of animal origin, but in beans, cereal grains, and potatoes as well.

Because of my neurological problem, I experience pain when anything is out of whack. I suspect that my response to Aspartame was due to slightly elevated brain levels of catecholamines.


How do you feel about aspartame and other artificial sweeteners?

See results without voting
Yours truly
Yours truly | Source

My recommendations

There are multiple causes for the obesity 'epidemic' in developed Western countries. For reasons I've mentioned in an earlier section, I think that artificial sweeteners are contributing in a small way to the problem.

If your body fat is in the optimum healthful range, if you don't have PKU, and if you're not diabetic or pre-diabetic, there's probably no harm in moderate consumption of artificial sweeteners as a guilty pleasure. Aspartame-sweetened soft drinks are not going to turn you into a frog. Another Scare-of-the-Month-Club myth bites the dust.

If you're dangerously obese, you should be aware that artificial sweeteners will NOT help you slim down. To some extent, artificial sweeteners will probably throw a monkey wrench into your good intentions. I'd advise you to discontinue all artificial sweeteners immediately. Old saying:

"To thine own self be true."

Secondly and more importantly, craft an exercise routine that's suited to your needs. This will require time, experimentation, and introspection.

I've written three earlier hubs on the subject. The first is an overview of the psychology of exercise.

The second hub is about fine-tuning your aerobic work for well-being. You're more likely to stick with an aerobic routine that doesn't make you miserable.

The third hub describes a simple exercise to strengthen the relatively large muscles in your upper legs. Increased lean muscle mass will increase your resting metabolic rate, and will burn more fat. This may or may not apply to you, but I've found that regular upper leg work also makes my big appetite slightly less big.

Copyright 2013 by Larry Fields

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Comments 17 comments

Nell Rose profile image

Nell Rose 3 years ago from England

Well its nice to see the real truth at last about Aspartame. I had heard rumours but never exactly what was wrong with it, I actually hate the taste, but do take sweeteners when on a diet, funny that now I know! voted up! nell


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi Nell,

Nice to hear from you, as always. And thanks for the vote up. You wrote: "...I actually hate the taste...."

I thought that I was the only person in the universe who disliked the taste of Aspartame. Now I'm wondering how many people don't believe their own lying taste buds, and think that 'diet' soda tastes sweet, because it's supposed to taste sweet!


Nell Rose profile image

Nell Rose 3 years ago from England

thats so true. I have given up tea at the moment, it tastes horrible, its funny because I was taking meds for my stomach and now can't bare tea! three weeks and counting, now I drink hot chocolate without sweeteners or sugar!


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi Nell,

Speaking of the devil, there's been some good press on the health benefits of chocolate in recent years.

http://news.bbc.co.uk/2/hi/health/6430777.stm

Well, actually it's for cacao, or unprocessed chocolate. Here in Northern California, the cheapest way to buy cacao is in the form of unsweetened Bakers Chocolate, which is available in most supermarkets.

At the moment, it doesn't agree with me. But when it did, I ate a 1/2 oz chunk of the stuff every day. At the time, it was somewhat helpful for my well-being.

Yes, it's bitter, but not unbearably so. It's an acquired taste.


Vickiw 3 years ago

I have never trusted any of these artificial sweeteners, and yes, they have a very strange taste. Probably it is worse, because I never use them, and so have never become used to them. Love the news about the chocolate. I have enjoyed it wholeheartedly since I first heard about that. Great research, great Hub.


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi Vicki. Thanks for stopping by.


Cantuhearmescream profile image

Cantuhearmescream 3 years ago from New York

Larry Fields,

I've been drinking Diet Pepsi for more than a decade and I'm sure you can imagine the concerned publics' advice that I've heard over and over again. I've heard both sides of the story but never any proof and so I've continued to do what I've always done. I prayed that reading your article wasn't going to result in feelings of guilt for consuming my Diet Pepsi. As you explained it, considering my personal circumstances; I can drink away. Thanks for clearing that up!


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi Cantuhearmescream,

Thanks for stopping by. If you don't have PKU, are not insulin-resistant, and are not overweight, the biggest risk associated with indulging your diet soda Jones is running afoul of Political Correctness, which claims that 'chemicals are bad for you'. As for the question of being out-of-the-closet about it, that's your call. :)


Cantuhearmescream profile image

Cantuhearmescream 3 years ago from New York

I live in America in the 21st century...everything is "bad" for me. If I did everything perfect for my health tonight, I'd be hit by a train tomorrow.

(Though I do appreciate your awareness and knowlege of healthy living and health related issues).

Eh, if I stopped drinking diet drinks, do-gooder know-it-alls would be learnin' me something else I "don't know". I'll just come to you the next time I want a real answer. Thanks


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Thanks for your vote of confidence.


Cantuhearmescream profile image

Cantuhearmescream 3 years ago from New York

You earned it buddy. When I clicked on your hub and saw that it was quite lengthy, but not in the boring, useless rant kind of way; I actually went and grabbed a blanket and a Diet Pepsi so that I could be fully dedicated to reading it! You really did a great job, I have yet to hear anyone give the kind of explanation of supporting facts to this debate as you.


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Thanks again. Not boring? I must be losing my touch. :)


beingwell profile image

beingwell 3 years ago from Bangkok

Voted up, larry. I'm not a fan of artificial sweeteners. At home, we use brown sugar, honey and maple syrup in making our foods a little sweeter. And yes, add cinnamon in the list too. Shared, as well.


NMLady profile image

NMLady 3 years ago from New Mexico & Arizona

The stuff is simply horrible for the human body. Nice article. Dr. Andrew Weil is thoroughly against this!


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi NMLady. Thanks for stopping by.


Larry Fields profile image

Larry Fields 3 years ago from Northern California Author

Hi beingwell,

Thanks for the share. Obesity is a bigger problem in my country than in Asia and the Philippines. We Americans can learn a thing or two from our cousins overseas.


G.Wood 3 years ago

I dont have PKU nor insulin resistance issues, but since childhood have have bad physical responce to Aspartame, its made me very sick for as long as I can remember and Im talking small doses like that in two sticks of chewing gum. Ive never been able to stomach even one whole can of any diet drink.. This life experiance tells me that there is something more to aspartame then just the above listed facts. I know of quite a few other people who have similar reactions be it nausea, dizziness, headaches etc from even small amounts of aspartame, reactions that I think help fuel the debate simply because it truely is bad for somepeople and many myself included would like to know why , if it is indeed as simple and innocent as is made out to be. Something to ponder.

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