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Mike Tyson's Punch-Out. Everything else is filler :-D
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The gut reaction is Mike Tyson's Punch-Outt!! but honestly, I think Punch-Out!! for the Wii is an improvement on it in every way. So I'll say that.
I've got to go with EA's Fight Night Round 4.
I really like the Punch-Out series of games and I grew up with the Mike Tyson's Punch-Out. Just got to go with the one that lets me play as the big names of the sport.
Super Punchout for the SNES is my personl favourite.
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