Autacoids - Definition, Function, Classification and General Overview

Structure of Histamine.
Structure of Histamine.

Autacoids

What is an autacoid? What is the definition? Auto means self and Akos means remedy. So autacoids basically can be defined as the chemical substances produced within the body to help in the remedy of local injuries.

Autacoids can be released by various stimuli and when released they bring about many physiological changes such as reddening of the skin, pain, itching, bronchospasm, etc. These effects can sometimes be undesirable and cause death. To prevent these autacoids antagonists are used.

Autacoids usually have very brief lifetime and act near the site of synthesis (local action).

Classification

1) Decarboxylated amino acids

a) Histamine

b) Serotonin

2) Polypeptide

a) Angiotensin

b) Plasmakinin

c) Vasopressin

d) Vasoactive Intestinal Polypeptide

e) Substance P

f) Slow reacting substance of anaphylaxis

3) Eicosanoid

a) Leukotrienes

b) Thromboxanes

c) Prostaglandins

Now it has been discovered that some autacoids are also found in nervous tissues. These are:

1. Histamine

2. Serotonin ( H hydroxytryptamine)

3. Prostaglandin

In the nervous tissues these autacoids function as neurotransmitters.

What’s the difference between autacoids and hormones?

1. Autacoids are produced by virtually all cells but hormones are produced by specific cells. Eg, insulin can only be produced by B cells of islets of Langerhans of pancreas.

2. Autacoids mainly act locally, ie, act near their site of synthesis but hormones are transported through the blood and act at distant target tissues.

Having said that, there are some hormones which can act as autacoids. For example, prostaglandins! Prostaglandin is a local hormone which also acts as an autacoid! This makes me want to say, “What’s there in a name?”!

So generally speaking, what’s the function of autacoids?

They take part in:

1. Inflammation

2. Allergic reactions

3. Anaphylactic reactions( not so much)

4. Neurotransmission

5. Gastric acid secretion

6. Neuroendocrine regulation

In the central nervous system, they are responsible for

1. Wakefulness

2. Decreased Appetite

3. Regulation of drinking

4. Regulation of temperature

5. Secretion of ADH

6. Control of blood pressure

7. Perception of pain.

We’ll discuss more about autacoids in the coming future. So stay tuned!


Comments 49 comments

Oyon 5 years ago

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ALAGI A.B.JARJU 5 years ago

U ARE DOING GOOD IN HELPING AFRICAN STUDENTS UNDERSTAND PHARMACOLOGY


abdallah gamal 5 years ago

good


althafhyder-india 4 years ago

good


BABLU VIMAL 4 years ago

I LIKE THIS TOPIC. THIS TOPIC IS VERY HELPFUL FOR ME.


katumba bruno. 4 years ago

This was so nice,no book explained me like u had done thanks.


raghvendra jha 4 years ago

it such a nice topic about the autocoids thanks


david 4 years ago

people like u are wot we need in the nation.Plz, keep it on


epharmacology profile image

epharmacology 3 years ago

Hi, nice article. I have also started writing about pharmacology on hubpages. You can see my page http://hubpages.com/@epharmacology

All the best.


ramjan khan 3 years ago

good ..............


jameel veesar 3 years ago

quite good ,soo brief


dixita kanojia 3 years ago

nice topic..... more lern in small contain.........


Zahidaky@hotmail.com 3 years ago

Very nice &comprehensive


hebatullah 3 years ago

good information

thank you


Raj 2 years ago

It's too good...i can understand it easily


nitin wat's 2 years ago

there is very easy to understand the autocoids....good..


endalamaw yehuala 2 years ago

a good info.......


Shameem 2 years ago

Very good information ,thank you very much


saher 2 years ago

thanks ot is very easy thanks 4 help


silmarllion 2 years ago

helpful article. thank you.


shafiullah khan 2 years ago

i like it so much


vandana yadav 2 years ago

it is so helpful thanks...


santosh keskar 2 years ago

Nice


Raja Sandeep 2 years ago

V.nice ...


rishika 2 years ago

nyc 1.... but not too brief


nice...... 2 years ago

nice...


dipendta 2 years ago

Awesome, this


ASAMINEW AZAD 2 years ago

I LIKE THIS.


dr.sanaulasyar 2 years ago

it is good and comprehensive


Amitab, DVM 2 years ago

GOOD. Easy to keep in mind.


GHULAM MUSTAFA PAKISTAN 2 years ago

VERY EASY THANKS


stella 2 years ago

Nice .easy and better remembering


Dr.Sk.Iquebal Alam 2 years ago

Nice ...............ski


Kona Sai Vasu Dev 2 years ago

as i'm a subject minded fellow i am not satisfied with this matter i want more stuff.....


kos 2 years ago

Good......


DEEPAK SHARMA 23 months ago

GOOD I LIKE THIS TOPIC BECAUSE IT GIVE GK ABOUT GENERAL FUNCTION OF BODY


syed daman 22 months ago

A reliable source .....


fffff 22 months ago

awesom


damini gupta 21 months ago

its vry gd topic..n thnku so much..


Bashir sani illela 21 months ago

Very nice thanks, but its too brief more stuffs are highly needed, such as mechanism of action, therapeutic uses, contra indications e.t.c for the benefit of student on reserch like me.


dr. naveed 20 months ago

Good


k.shiva 20 months ago

Gd info thank u


Pradeep Singh 20 months ago

I like this.....

Nice....


Malik Dawood 17 months ago

Wonderful keypoint notes. Good for revision. Thanks.


Rakesh Mudideni 16 months ago

Good. It's easy to understand. But, need some stuff.


Dastagiri 9 months ago

So nice information

Thank you


dodo 9 months ago

thanks dats a concise information.


Jan 9 months ago

I am missing the lipid autacoids such as the N-acyethanolamides, like palmitoylethanolamide, the resolvins, the protectins, the maresins... especially important since these all modulate explosive inflammation processes.....


dr , raheem razaq 5 days ago

vary helpfull information dut it varry short if more comprehansiv its too good

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