Biochemical Explanation of Children with Autism and ADHD: Deletions in Electron Transport Chain.

Mitochondrial Electron Transport Chain

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Biochemical Explanation of Autism and ADHD

Biochemical Explanation of Children with Autism and ADHD

The prevalence of children with Autism and children with ADHD is increasing exponentially. What is abundantly clear from a behavioral perspective is that these child are suffer from a biochemical disorder and not behavioral problems. So behavioral intervention is not only unwarranted but in many instances may be cruelty. A diabetic with an elevated blood sugar also has behavioral abnormalities but our society has progress to recognize that this is a biochemical problem and not a behavioral one. This leap in understanding should be applied to children with Autism and ADHD.

Although I was not able to obtain video of an explanation of how children with biochemical problems like mitochondrial cytopathies electron transport chain compensate with deletions in their electron transport chain of cellular respiration in their mitochondria. I am at least able to bring you videos of how typically developing peers biochemistry works within their bodies. This is thanks to the Khanacademy.

If you would follow the videos and pay particular attention to the mitochondria explanation of the Electron Transport Chain or ETC and recognize that the end result is the creation of energy throughout the intercellular and extra cellular membranes. I may be able to illuminate further in my conclusion.

I have been studying biochemistry for a decade. If you don’t understand at first don’t worry. It is like anything else it takes time to comprehend such sophisticated concepts. More over there is still serious scientific debates as these theories are ongoing.

But in order for me to explain my theory, you will have to have some basic knowledge of cellular respiration and the electron transport chain. These videos will help you understand. You may need to watch them more then once but they are a very good reference although not all inclusive.




Gylcosis

Electron Transport Chain

In Conclusion

Although scientific consensus has not been reached regarding the production of ATP within the body, I submit that children suffering for either Autism or ADHD have an a deletion in their mitochondrial electron transport chain in which they produce ATP from glycosis less efficiently subesequently causing lactic acid to be used as a compensatory fuel within their cells which is very harmful to their bodies long term and alters neurological function within the brain therefore creating Autism and ADHD. Children can be readily tested for lactic acidosis as the test runs about $12 but the pyruvate acid test is a bit higher. The gold standard for being tested for mitochondrial cytopathies is about $25K and there is no current cure. It involves a skin biopsy and a muscle biopsy as well as blood and urine tests.

It is estimated that one in every five thousand people have a a mitochondrial cytopathy but some people are more apparently effected than others.

My son was diagnosed with this disease and tested positive for it when he was two. At the time it was not believed he would live very long. My son is now 11 and 1/2. But I am very cautious and I follow the biochemistry and have studied for a decade because I have had to. I am ever vigilant against disease and I make certain my son is not over stressed, over heated and I seek medical advice when he has the sniffles. His quality of live is good. And while he has full blown Autism and Mitochondrial Cytopathies he is one of the lucky children that can run and play and is thriving. And as incredibly hard as this life has been on both of us, it has been an education. There is a lot of room for research in mitochondrial cytopathies as they related to Autism, ADHD and mental retardation. For guidelines to consider whether your child might have mitochondrial cytopathies please see the united mitochondrial disease foundation.


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Comments 20 comments

Denise Handlon profile image

Denise Handlon 5 years ago from North Carolina

Wow! this is interesting. My mind can't quite wrap around the whole concept, however, your point about the behavior and the biochemistry makes sense. Thanks for sharing your experience, JT


jt Walters 5 years ago

Hi Denise,

It took me many years to wrap my head around biochemistry as well. But it is very relevant to today's medicine and all of us need to graps it so we can make informed decisions about our medical care.

And yes, I believe ADHD and Autims is a metabolic biochemical medical issue and not a behavioral one. I relaize that people will not agreew ith me and this is alesser made argument.

Thanks for reading, taking the time to comment and post.

Cheers.

JT


emmy1980 profile image

emmy1980 5 years ago from North Carolina

I totally agree that there must be a biochemical aspect to the disorder. This is very interesting and I hope your ideas get further attention and study. I did have to mention, however, that my sons benefited tremendously from behavioral interventions, and at no point was it cruel. Not sure what you meant by that - I think you meant the people who think these kids are just "acting up" and "need to be spanked more"? That certainly wasn't the case. I think of "behavioral interventions" as all the ABA-style therapies I used to reshape certain behaviors. Just wanted to clarify that because some people might misconstrue the meaning. :)


JT Walters profile image

JT Walters 5 years ago from Florida Author

Hi Emmy1980,

I am a behavioral therapist as well. I am speaking specifically to level three behavioral interventions which I believe to be completely and totally inappropriate when a child is suffering a metabolic crisis. The point is to metabolically balance a child with Autism before any behavioral intervetion is used as medical interventions for metaolbic disorders preserve the child's brain and body.

Gleening from the example of the diabetic with high blood sugar because children with metabolic acidosis also suffer from high and low blood sugars which effect their behaviors any intervention beyond medical stabilization are inappropriate as they silence the child and don't pass the dead man's test.

If you don't know what a dead man's test is I will explain. As a behavioral therpaist you never exitinguish functional behavior. Acting out maybe the way of a non-verbal autistic's child communication that he is in metabolic distress. To silence or effectively extinguish his acting out behavior before identifying whether he is metabolic crisis is abusive. You have taken his only form of communication from him that he is in crisis. It can be true with verbal austistic children as well. Behavior is a cry for help and it shouldn't be silenced without establishing the etiology of the behavior which in the case of Autism may very well be a biochemical/metabolic crisis in thier bodies.

So you don't teach silence to autistic children because dead men are silent and you never teach a behavior that a dead man does. It is called the "dead man's" test and it is suppose to be applied to every behavioral intervention including but not limited to extinction of behaviors and teach of behaviors.

Were I see a great deal of opportunity is in usng Verbal Operants from Skinner's Verba Behavior to teach language and the acquisition of skills. I alos love Jim Partington's work.

As a special educator, a scietist, a researcher, a parent of a child with autism, I can guarantee you that while behavioralism is useful it is not the answer for children with autism. Child with Autism need to be medically stabilized before any behavioral intervention is appropriate.

But I will also admit behavioralism is the only tool we have in the tool box right now for Autism and that I find most unfortunate.

Thanks for reading, commenting and providing feedback. I enjoyed our story and I hope to read you in the future on hubpages.

All My Best,

JT


emmy1980 profile image

emmy1980 5 years ago from North Carolina

Okay, thanks. I didn't think you meant ALL behavorial interventions were cruel. That explanation made sense.


JT Walters profile image

JT Walters 5 years ago from Florida Author

No problem. Thank you for giving me the opportunity to clarify.

JT


R. J. Lefebvre 5 years ago

JT Walters,

Your hub grabs me! I have to admit there were times I had witnessed people young and old who were different by no choice of their own. I felt offenced by seeing other bystanders who could not hide their pretense. I had no way of knowing how address one, without making him/her feel less then worthy than their peers. My best was to greet or talk in a way I would want if it were me. I admire your identity by your hubs, your child could not have a better parent.

Ronnie


JT Walters profile image

JT Walters 5 years ago from Florida Author

Thanks Ronnie,

My son is the great one. I am just along for the ride. He inspires me to be a better person each day.

Thank you for your kind words. They are so appreciated. I may write a hub on how to interact with the disabled for those who are uncomfortable.

Thank you so much for responding and for your kindness.

JT


Lord De Cross profile image

Lord De Cross 4 years ago

Geez!! JT!

How do you want me to comment on thermodynamics of biochemical connection with Autism and ADHD?

Entropically speaking, I suspect you have a 70/30 chance to be right! Makes all sense to me now. The thing is..if someone is to be blame..surely will be our Own Government..but please!! Can you give them a break on these Holidays? They need to go to Cancun, Baja or Bermuda... We all are humans..so, easy on them...Omg! 2.48 a.m...gotta go!

LORD


JT Walters profile image

JT Walters 4 years ago from Florida Author

Hi Lord,

Alright, I will be nice to our government over the holidays. I mean it isn't like Autism can't wait another twenty years while they are all on vacation. This article was written a while back but I believe the research to be sound. It offers everyone possibilities which didn't exist before. But I hear you..vacations.

When my son if President then Autism will finally be addressed as the biochemical disease which it is. And that was energy (Heat) and cellular kinetics that is applicable for intercellular and extra cellular regulation.

This has not been one of my more popular hubs as it has only received one rating. And OMG 3:20 but I am on vacation be frivilous so I can stay up late.

Goodnight my friend.

JT


Lord De Cross profile image

Lord De Cross 4 years ago

Good night!


JT Walters profile image

JT Walters 4 years ago from Florida Author

Night D,

JT


Credence2 profile image

Credence2 4 years ago from Florida (Space Coast)

Jt, I took the time and checked this out. A most interesting lesson in microbiology. How delicate and intricate it all appears to be. Of course, a biochemical deficiency as the cause of behavior abnormalities is the most sensible conclusion to come to in this and many other maladies, maybe like diabetes. Seems like as the moderator had said, we are on the cutting edge of just understanding how all this works, to figure how Autism constitutes an error is this elaborate process will require all the more intense R and D, and I certainly hope that it is forthcoming. Thanks, Cred2


JT Walters profile image

JT Walters 4 years ago from Florida Author

HI Cred2,

Actually we can test for inborn errors in metabolism as my son has been diagnosed and it is thought to be the cause of Autism. There just hasn't been enough funding to prove it. And while addressing Autism is a singular issue, the research has applications to cancer research, parkinson's and alheizmers.

Cred2 this is 30 year old research. And if I can understand it then we are already behind. We can put these very early interevntion tests into place like the PKU and cut billions of dollars off costs later by miniminalizing costs later. Not to mention it is the moral and ethical thing to do. And this isn't a partisanship thing at all but a place to start. Verify in born errors in metabolism and correct for them minimizing brain damage in children.

I know I am boring and passionate about this subject matter and it is a turn off to my audience. I appreciate you reading and taking the time to comment.

Has anyone every told you, you write like a lawyer? I read your bio and I know you didn't cmplete your MBA but you really write like a lawyer. I can wrtie that way as well and have won some cases as a non-lawyer in administrative hearings. So I recognize this in you. A law career could be calling you.

Mahalo!!

JT


Credence2 profile image

Credence2 4 years ago from Florida (Space Coast)

As for my writing, thanks for the compliment, and you are not so bad yourself. It is quite a challenge to get so technical a topic broken down in to bite size morsels that the layman can understand. The use of the professor and videos are well inspired.


JT Walters profile image

JT Walters 4 years ago from Florida Author

Thanks Cred2,

You are awesome.

JT


Credence2 profile image

Credence2 4 years ago from Florida (Space Coast)

Oh, JT I am retired but I would like to go into the law, but it takes a lot of energy to get started again after having already completing career. Matery of legaleze was part of may job in awarding federal contracts, that was the biggest occupational use. I would sure like to delve into it as more than just a hobby. Thanks for being so astute.


JT Walters profile image

JT Walters 4 years ago from Florida Author

Cred2,

I am a Rough Rider which means I am 1/3 West Point graduate, 1/3 surgeon and 1/3 lawyer. It was just very apparent by your writing because I have done it as well. You are good. Maybe you could find a way to do it as a consultant to the aerospace industry they always need an insider in figuring out how to get government contracts. You are a retired insider.

You are astute as well. It is good to get to know you.

All My Best,

JT


Credence2 profile image

Credence2 4 years ago from Florida (Space Coast)

You graduated from West Point? Thanks for the compliment, I believe that I have written many timely articles on a variety of subjects. Things are difficult because of my location, there are not a lot of opportunities here on gilligans island, except process coconut milk. Thanks for you attention


JT Walters profile image

JT Walters 4 years ago from Florida Author

No just the Rough Riders in my family. They were all West Point graduates, doctors and lawyers. My Da actually didn't go to West Point he just worked for General Westmooreland(?). It is rumored my dad convinced Westmooreland to retire. But I have never meet General Westmooreland. I doubt my son and I will be as welcome in Japan as you have offered Hawaii though.

:)

LOL

JT

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