Causes of Peyronie's Disease

Dupuytren's Disease
Dupuytren's Disease | Source
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Peyronie's disease is shrouded in mystery. This insidious condition is afflicting men all over the world, and seems to be growing into an epidemic, veiled in secrecy. I am writing this book to share the battle plan that I developed to win the war on my Peyronie's disease. I will start off with an overview of the causes of this devastating condition.

Peyronie's disease, in spite of how common it occurs, and the physical and emotional havoc it causes, is not well understood. There really isn't a lot of medical research or information available for patients. I never had a doctor give me a handout on Peyronie's disease. They never gave me any advice on foods to avoid, or lifestyle changes to make. The medical practitioners in America for the large part are at a loss about how to treat and cure this condition. If vitamin E or Verapamil do not work, the alternative is surgery, or worse yet, just wait for it to go away or get better.

Interviews with Urologists that treat this condition, estimate that 8.9 to 10% of men have palpable plaque buildup in their penises at one time or another. Between 1 to 3% of men develop sufficient plaque/scar tissue to prevent them from performing sexually. Often erections in those afflicted are accompanied by various levels of pain. These 1 to 3% are the men that need to seek treatment options.

Injury: Many doctors believe the main cause of Peyronie's disease is due to an injury of the penis. The problem with this theory, is that most men that suffer with this condition, have no memory of any injury or trauma. Penile fracture is a traumatic and violent breaking of the penis, usually caused during vigorous sexual intercourse when the penis misses the intended target and is forcibly ruptured, much like a tire busting. This is caused by blunt trauma or excessive lateral pressure. Any man who has suffered a broken penis, will have no doubt as to the cause of his Peyronie's disease.

Dupuytren's Disease: There is a high association of Dupuytren's with Peyronie's disease and Plantar fibromatosis. Dupuytren's is a fibrotic tissue disorder that affects the hands. This is a condition where excess collagen or fibrotic tissue form together and cause firm lumps in the palm and fingers. Over time the collagen may build up on tendons, causing contracture of one or more fingers. It is common for Dupuytren's to develop in both hands. This condition is considered to have genetic causes and is most common in people of Northern European ancestry. Dupuytren's is often treated with surgery, with recurrence after surgery somewhat common.

Excess Collagen: A common thread with Peyronie's disease is; excess collagen build-up in the body. Many people are in the practice of taking health food supplements, in an attempt to stave off the effects of age. It has become very popular in recent years to heavily supplement with Glucosamine/Chondroitin. Many people drink Knox gelatin on a regular basis. This healthy practice, is beneficial to reduce joint pain and back pain. Healthy hair and strong nails are another by-product. You might remember an audiotape entitled; "Dead Doctors don't Lie!" It was very popular a few years back and consuming Knox drinking gelatin was highly recommended. I was a convert and began self medicating regularly. Over time I believe that an excessive build up of Collagen can cause serious and possibly life threatening conditions to develop. Collagen is great where it belongs, but you do not want it building up in your internal organs, arteries and blood stream or in your penis. Collagen supplementation seems to be a common thread in the Peyronie's forum. I believe it caused my Peyronie's disease, along with a blockage in my brains' vision center, that almost caused me to have a stroke. I had an episode called a transient ischemic attack, which is also called an ischemic stroke. The doctor's could not find any cause for this, even after doing an MRI, a carotid artery ultrasound, a stress test, and examination by an ophthalmologist. Looking back, I believe this was caused by ingesting excess collagen.

Viagra and Peyronie's: Viagra, Cialis, and Levitra are all classified as PDE5 inhibitor drugs. These drugs work by blocking the PDE5 enzyme, that inhibits erection. You may have heard about the risk of heart attack and stroke with these drugs. It is not the reaction to the drug that causes the heart attack. It is usually caused by the poor cardio fitness of the individual, related to vigorous sexual activity, and elevated heart rate. PDE5 inhibitors, smooth and relax the muscles of the penis, allowing the blood to flow more freely. In 2002, it was reported by the International Journal of Impotence Research, the number of Peyronie's patients has increased since the advent of oral Sildenafil.  The report did state that there was not any evidence that Sildenafil was causing this increase.  Why in my opinion is this happening? PDE5 inhibitor drugs allow a man to maintain a very long lasting erection, which creates an artificial condition. The penis it appears may not be designed to sustain greater than normal pressure for extended periods of time, especially at the site of the Peyronie's plaque. The super boner makes a man feel like superman, but PDE5 inhibitor drugs may be involved in the onset of Peyronie's disease in some cases.  Patients with Peyronie's disease, should always consult with their doctor or urologist before using erectile medications.

Diabetes: Peyronie's disease and Diabetes have a high association. If you have Peyronie's, your doctor should test you for insulin resistance and assess your risk for Diabetes. High Blood Pressure and Atherosclerosis are also highly associated with Peyronie's. Your doctor can also check for these serious health threats. When you are being evaluated for Peyronie's, you should ask your doctor to test for these conditions. Don't expect him to automatically know about this. Most general practitioners have very little experience in treating Peyronie's disease.

Clinical studies and research are much more prevalent in Europe. Peyronie's disease is rarely found in men of Asian and African descent. Men of European descent comprise the majority of cases. American Medical practitioners have for a large part, ignored this problem and many men are relegated to the ranks of those suffering in quiet desperation.

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