How to lower ammonia in your body
Changing your diet to help with ammonia issues
Having a single or double A1298 MTHFR (Methylenetetrahydrafolatereductase) mutation will lower levels of BH4 (made worse or better depending on other mutations) and will make it difficult to properly detoxify ammonia which can lead to various health problems/symptoms.
Other SNP (singular nucleotide polymorphisms) mutations such as NOS (nitric oxide synthase enzyme), SUOX (sulfite oxidase enzyme), CBS (cystathionine beta synthase enzyme). NOS mutations will lower levels of nitric oxide in the blood, further making it difficult to detoxify nitric oxide as boosting nitric oxide can help detoxify ammonia among other health benefits (for more information on boosting nitric oxide check out: http://jheldt.hubpages.com/hub/How-to-naturally-raise-Nitric-Oxide).
CBS mutations will affect the production and conversion of homocysteine into glutathione (a major antioxidant) and will produce more sulfur end products (if you have SUOX mutations will make it worse), and make it harder to detoxify and cycle ammonia through the body. SUOX mutations will affect your body's ability to deal with sulfur and also with ammonia as well.
Treating those with low Tetrahydrobiopterin (BH4, fore more information check out: http://en.wikipedia.org/wiki/Tetrahydrobiopterin) and therefore a decreased ability to detoxify and process ammonia takes a two fold approach. The first part of the approach is limiting foods high in ammonia.
The other part of the approach is introducing supplements to help detoxify ammonia but also raise levels of BH4. Lowering foods in thiols/sulfur compounds may be necessary as well (but not always). Ammonia is typically found in foods with high protein. I would also recommend changing your diet to a paleo template/weston a price diet, as it eliminates a lot of problematic foods.
Supplementing with amino acids is highly recommended for someone that needs to go on a lower protein diet. Lowering protein intake may affect the amount of amino acids you intake as well. Amino acids may also help dealing with other methylenetetrahydrafolatereductase (mthfr) and detox snps (singular nucleotide polymorphisms) as well. While everyone requires different amounts of macro nutrients such as protein, fat and carbs for someone that needs to lower protein a 30/30/30 (rough percentage split of protein/fat/carb) would be a good place to start.
Here is a list of high thiol foods: http://www.livingnetwork.co.za/chelationnetwork/food/high-sulfur-sulphur-food-list/
Here is a list of foods high in ammonia: http://wholefoodcatalog.info/nutrient/ammonia/foods/high/
500 mg of L-Ornithine, you can take up to 6 of these a day to deal with ammonia and helps a lot with brain fog I have found as well.
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Yucca root (tablet)
You can take this up to a couple of times a day, helps to lower ammonia and can help with other health issues as well. It has been used by Native Americans for hundreds of years for a variety of conditions.
Take 3-4 of these with two charcoal pills 2-3 hours after falling asleep to do a charcoal flush. Magnesium citrate is nontoxic and when taken at higher doses is a mild laxative, in about 8-12 hours it will induce a bowel movement and combined with the charcoal will not only lower ammonia but also help with heavy metals/chemicals.
Supplements to help lower ammonia and raise BH4
While lowering ammonia intake should be the first priority its also ideal to supplement with supplements that raise BH4 and lower ammonia. Yucca root is commonly used to lower ammonia in the body and I personally use an alcohol extract and yucca root capsule to get a double dose of yucca. L-orthinine I have found to be very helpful, I have tried using supplementing using powders and capsule form and found using capsules to be more efficient and effective.
Take it slow with using orthinine as it helps to detoxify ammonia in the Urea cycle (the pee/urine cycle), and have found it to help a lot with brain fog. You can take up to 3 grams of L-orthinine but its best to work your way up to that amount as there are sometimes side effects.
Supplementing with royal jelly and Nicotinamide adenine dinucleotide (NADH co enzyme of B6, check out for more information: http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide ) also helps to raise levels of BH4 as well. As with all supplements its wise to start with one supplement at a time, and add supplements every couple of days. Also work the dosage you use for each supplement over time. This can help point out which supplements help the most, side effects and ones to possibly avoid. Those with detox/methylation SNPs can often have severe side effects and can be particularly sensitive so take it slow with supplements.
I also do a once weekly charcoal/magnesium citrate flush which is really quite simple to do. All it requires is using magnesium citrate and charcoal. I take two capsules of charcoal and 2-3 of magnesium citrate (about 800-1000 mg depending on supplement). I usually wake up a few hours after going to bed (I set an alarm) and take both at the same time. There are a few other ways to do a charcoal flush but I find that is the easiest way to do it. It will flush your body of ammonia and only needs to be done once a week.
Yucca Root extract
You can take this up to a couple of times to day to help with ammonia, I typically take both forms of yucca to help with ammonia.
Finding help with detoxifaction and methylation SNPs
Since I am not a doctor, naturopath or health specialist (I am an independent health investigator though), with no formal medical background I would highly suggest finding a qualified and competent health specialist. Finding an mthfr specialist will help a lot with treating mthfr, detox and methylation snps. While you can do a google search for "mthfr specialist", "mthfr doctor", there are many doctors who have limited to little knowledge of how to treat or diagnose these health issues.
There has only been so much research done on these issues as well, which I believe to be behind many common ailments. I have found MTHFR support website, Insight Naturopathy, Amy Yasko and Dr Ben Lynch's website to be very helpful. On the MTHFR support website you can find a directory of MTHFR specialists/doctors to help you. Amy Yasko as well as insight naturopathy does a lot of research into methylation, detoxifaction and other related complex health issues. I would highly suggest taking a 23andme test if you suspect you may be dealing with these health issues as well.
I would also highly suggest checking out Chris Kresser's website as well. Chris Kresser is a modern day real life "Dr. House" who researches, treats and writes about chronic and complex health conditions. He does touch on methylation and MTHFR from time to time but his website is invaluable. His approach is really innovative and unique in that everyone is unique and requires a unique approach when it comes to diet and treatment.
Insight Naturopathy: https://www.facebook.com/pages/Insight-Naturopathy/226698217365990
MTHFR support: http://mthfrsupport.com/
Amy Yasko: http://www.dramyyasko.com/
Dr Ben Lynch: http://mthfr.net/
Chris Kresser: www.chriskresser.com
Only need to take one of these to help with ammonia and raise BH4
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Supplements and natural therapies for those dealing with chronic health conditions ranging from mthfr defects, chronic fatigue syndrome, thyroid, adrenal and digestive issues.
Activated charcoal to be used in charcoal flush.
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I only use a low dosage of 5 mg which helps with energy, cellular energy and helps with ammonia as well.
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