Medicinal Uses of Feverfew

Feverfew (Tanacetum parthenium (L.) Sch.Bip., 1844) is a plant of the Asteraceae family. In Italy, depending on where it is concosciuta with the names of amarella, amareggiola, matrical marga and grass.It is a herbal plant.

Distribution and habitat

 It can be found in stony places and uneducated of the temperate European, North and South America and in the Caucasus region. In Italy is located in the gardens for ornamental purposes only.

Active

 Feverfew has a good amount of flavonoids such as luteolin, quercetin, apigenin and axillarina, which owes part of its spasmolytic action on visceral smooth muscle. It also has compounds called bi-or tricyclic sesquiterpenes, such as parthenolide, the costunolide the artemorina and Santamarina, who are bitter and modulate the functions of the serotonin system, from which the property of their prophylactic migraine event. Note that the starting infusions are effective only as a preventive of the attack have no effect when the migraine is in progress.

Traditional and New Uses

 

In popular folklore, feverfew has found use in rheumatic conditions and prevention of cerfalee. In modern herbal medicine is mainly used in the prophylaxis of migraine. However, it has good tonic, emmenagogue and antispasmodic. This makes it a good palliative care for women suffering from dysmenorrhea (irregular menstruation and / or painful).

 

Feverfew should not be used in people who have allergies to other Asteraceae and indeed should consult your doctor before taking feverfew.

 

For nearly a decade, feverfew has aroused interest among researchers on the immunology, rheumatology and oncology. One of his constituents, in fact, parthenolide, was a powerful anti-inflammatory in the laboratory on experimental animal models of debilitating diseases such as rheumatoid arthritis and lupus erythematosus.

 

This compound acts directly as an inhibitor of the transcription factor kappa B-lymphocyte antibody (NF-kB), which serves to immune cells to the synthesis of many cytokines involved in inflammation. Furthermore it has the advantage of also directly inhibit 5-lipoxygenase, an enzyme that converts arachidonic acid in the known inflammatory mediators leukotrienes.

 

The parthenolide is very effective in eliminating, or at least in vitro models of tumor tissue transplanted into experimental animals, the proliferation of certain malignant cells from solid tumors that establishments (gastric cancer, lung, prostate and multiple myeloma, to name a few). Apart from its inhibitory effect on power factor NF-kB, as mentioned above, the alkylation parthenolide the enzyme DNA-cytosine methyltransferases (DNMT 1), amending the DNA leading to gene repression of many portions of chromatin. In practice, the parthenolide would act the same way as 5-azacytidine chemotherapy, used as an inducer of cell differentiation in the treatment of hematologic malignancies (multiple myeloma, myelodysplastic syndromes, etc.)..

 

However, missing data from human clinical trials in this regard.

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Comments 2 comments

JC Auckland 5 years ago

Excellent. I have this is my garden. They say a leaf or two in your sandwich every day is good against headaches. I often make a pot of tea from a handful of leaves.


Enrique 24 months ago

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