Nutritional Treatments of Autism - Summary and References

SUMMARY

It certainly seems that dietary approaches have a lot to offer those with autism. However, large scale, good quality research is essential to finalise these details. However, I feel that the information discussed above should be much more readily available and given to those families with autistic children to enable them to make their own decisions about whether they would like to try it.

Recommendations for Further Research

B6 and Magnesium

Research the use of pyridoxal-5-phosphate with autism

Perform larger scale studies

Ascertain why it works

Ascertain minimum effective dose

Fatty Acids

Perform larger scale studies

Ascertain why it works

Ascertain minimum effective dose

Gluten Free Casein Free Diet

Perform larger scale studies

Ascertain why it works

Ascertain whether use of supplements (perhaps enzymes) would have the same effect with no need for change in diet

Summary for Parents

B6 and Magnesium

Simple to implement

Cheap

Safe

Increase dosage slowly until improvement is seen

Fatty Acids

Simple to implement

Cheap

Safe

Increase dosage slowly until improvement is seen

Gluten Free Casein Free Diet

Cheap

Needs a good understand of ingredients in food

Follow casein free diet first for a couple of weeks and follow with gluten free

Safe

ACKNOWLEDGEMENTS

I would like to the National Autistic Society and Ann Mari Knivsberg, who have been particularly helpful in providing me with the information necessary for this project.

REFERENCES

Adams, J et al (2006) Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. Journal of Alternative and Complementary Medicine. 12:59-64

Adams, JB and Holloway C (2004) Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med. 12:1033-1039

Arnold, GL et al (2003) Plasma amino acid profiles in children with autism: potential risk of nutritional deficiencies. Journal of Autism and Developmental Disorders. 33:4:449-454

Audhya, T (2002) Laboratory indices of vitamin and mineral deficiency in autism. Conference proceedings of the Fall DAN 2002 Conference, San Diego, CA, 239-244

Autism Research Institute (2006) Autism Research Institute [Internet], San Diego, USA. Available from: <http://www.autism.com/ari/> [Accessed 10th December 2006]

Autism Research Unit (1999) The Use of Secretin for the treatment of Autism [Internet], Sunderland, UK. Available from: <http://osiris.sunderland.ac.uk/autism/sec.htm> [Accessed 10th December 2006]

Barthelemy C. et al (1988) Urinary free and conjugated catecholamines and metabolites in autistic children. Journal of Autism and Developmental Disorders, Vol. 18(4), pp. 583-591

Barthelemy, C et al (1980) Biological and clinical effects of oral magnesium and associated magnesium-vitamin B6 administration on certain disorders observed in infantile autism. Therapie. 35(5):627-632

Barthelemy, C et al (1981) Behavioral and biological effects of oral magnesium, vitamin B6, and combined magnesium-B6 administration in autistic children. Magnesium Bulletin. 2:150-153

Barthelemy, C et al (1983) Behavioural and biological effects of oral magnesium, vitamin B6 and combined magnesium-B6 administration in autistic children. Neuropsychiaurie de l’Enfance. 31:289-301

Barthelemy, C et al (1983) Value of behavior scales and urinary homovanillic acid determinations in monitoring the combined treatment with vitamin B6 and magnesium of children displaying autistic behaviour. Neuropsychiatric de L’Enfance et de l’Adolescence. 31(5-6):289-201

Bell, J et al (2000) Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: A characteristic abnormality in neurodevelopmental disorders? Prostaglandins Leukotrienes and Essential Fatty Acids. 63, 21-25

Bell, J et al (2003) Essential fatty acids and phospholipase A2 in autistic spectrum disorders. Prostaglandins Leukotrienes and Essential Fatty Acids. 71, 201-204

Bonisch, E (1968) Experiences with pyrithioxin in brain-damaged children with autistic syndrome. Praxis der Kinderpsychologie und Kinderpsychiatrie. 17(8)308-310

Bonisch, V.E. (1984). Erfahrungen mit pyrithioxin bei hirngeschadigten kindern mit autistischem syndrom. Praxis der Kinderpsychologie 8, 308-310.

Bryhn, M (2005) Children and Omega-3 Fatty Acids [Internet], Guernsey, UK. Available from: < http://www.omega3forchildren.co.uk/articles/article_details.aspx?id=236 > [Accessed 29th April 2007]

Bu, B et al (2006) Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukotrienes and Essential Fatty Acids. 74, 215-221

Burgess, J.R., Stevens, L., Zhang, W., & Peck, L. (2000). Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. American Journal of Clinical Nutrition. 71(1), 327-330.

Cade, R et al (1999) Autism and schizophrenia: intestinal disorders. Nutritional Neuroscience. vol 3 pp57-72

Center for The Study of Autism (2002) Vitamin B6 and Magnesium [Internet], Oregon, USA. Available from: <http://www.autism.org/vitaminb6.html> [Accessed 22nd April 2007]

Colquhoun, I., & Bunday, S. (1981). A lack of essential fatty acids as a possible cause of hyperactivity in children. Medical Hypotheses. 7, 673-679.

Connor, M (2004) Autism and Nutritional Intervention [Internet], Surrey, UK. Available from: <http://www.mugsy.org/connor47.htm> [Accessed 4th December 2006]

Cornish, E (2002) Gluten and casein free diets in autism: a study of the effects on food choice and nutrition. J Hum Nutr Diet. 15:261-269

DeFelice, KL (2002). Enzymes for Autism and Other Neurological Condition. Johnston, USA, Thundersnow Interactive.

DHA in Mind (2007) DHA in Brain and Retine Structure[Internet], Australia. Available from: < http://www.dhainmind.com/portals/0/pdf%20files/dha_inbrain_and_retinastructure.pdf> [Accessed 29th April 2007]

Dobbing, J (1990) Brain, Behaviour and Iron in the Infant Diet. USA, Springer Verlag.

Edelson, S (2002) Leaky Gut and Gluten / Casein Free Diet [Internet], Oregon, USA. Available from: < http://www.autism.org/leakygut.html> [Accessed 29th April 2007]

Edelson, S (2002) Leaky Gut and the Gluten Free Casein Free Diet [Internet], Salem, USA. Available from: <http://www.autism.org/leakygut.html > [Accessed 10th December 2006]

Edelson, S (2002) Vitamin B6 and Magnesium [Internet], Salem, Oregon, USA. Available from: < http://www.autism.org/vitaminb6.html> [Accessed 4th December 2006]

Edelson, SM (2002) Vitamin B6 and Magnesium [Internet], Salem, USA. Available from: < http://www.autism.org/vitaminb6.html> [Accessed 10th December 2006]

Elder, JH et al (2006) The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. Journal of Autism and Developmental Disorders. 36(3):413-420

Equazen (2006) Equazen [Internet], London, UK. Available from: <http://www.equazen.com> [Accessed 10th December 2006]

Findling, RI et al (1997) High dose pyridoxine and magnesium administration in children with autistic disorder: An absence of salutary effects in a double-blind, placebo-controlled study. Journal of Autism and Developmental Disabilities. 27(4):467-478

Food and Behaviour Research (2003) Food and Behaviour Research [Internet], Inverness, Scotland. Available from: <http://www.fabresearch.org> [Accessed 10th December 2006]

Garner C. et al (1986) Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children. Journal of Autism and Developmental Disorders, 1986, Vol. 16(1), pp. 23-29

Gesch, B (2002) Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Brit J Psychiatry. Vol 181, 2002, pp. 22-28.

Gillberg, C (1988) The role of the endogenous opioids in autism and possible relationship to clinical features. Aspects of autism : biological research / edited by L. Wing. pp.31-37, London: Gaskell/National Autistic Society

Gordon, GF (2004) More Studies on High Iron Levels [Internet], Payson, USA. Available from: <http://www.gordonresearch.com/answers/more_studies_on_high_iron_levels.html> [Accessed 10th December 2006]

Heeley AF and Roberts GE (1966). A study of tryptopban metabolism in psychotic children. Dev Med Child Neurol. 8:708-718.

Holman, P (2006) Pyridoxine – B6 [Internet], Victoria, Australia. Available from < http://www.acnem.org/journal/14-1_july_1995/pyridoxine-vitamin_b6.htm#Figure%203> [Accessed 22nd April 2007]

Hopkins, J.N. (1999). The effects of vitamin B6 supplements on the behaviour and brain activity of subjects with autism. Unpublished master’s thesis, Swinburne University of Technology, Victoria, Australia.

Jonas, C et al (1984) Clinical and biochemical value of magnesium and vitamin B6 combination in the treatment of residual autism in adults. Therapie. 39(6)661-669

Kane, PC (1999) The neurobiology of lipids in autistic spectrum disorder.

Knivsberg, AM et al (1990) A survey of dietary intervention in autism. Centre for Reading Research, Norway

Knivsberg, AM et al (1990) Dietary intervention in autistic syndromes. Brain Dysfunct. 3:315-327

Knivsberg, AM et al (1995) Autistic syndromes and diet: a follow-up study. Scandinavian Journal of Educational Research. 39:3:223-236

Knivsberg, AM et al (1998) Gluten and casein free diet for children with autistic syndromes. A single blind controlled study. Centre for Reading Research, Norway

Knivsberg, AM et al (2001) Reports on dietary intervention in autistic disorders. Nutritional Neuroscience. vol 4 pp 25-37

Knivsberg, AM et al (2002) A randomised, controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience. vol 5(4) 251-261

Knivsberg, AM et al (2003) Effect of a dietary intervention on autistic behaviour. Focus on Autism and other Developmental Disabilities. 18;4:247-256

Kuriyama, S et al (2002) Pyridoxine treatment in a subgroup of children with pervasive developmental disorders. Developmental Medicine and Child Neurology. 44:283-286

Lelord, G et al (1978) Effects of pyridoxine and magnesium on autistic symptoms - initial observations. Rev Neurol (Paris). 134(12)797-801

Lelord, G et al (1981) Effects of pyridoxine and magnesium on autistic symptoms - initial observations. Journal of Autism and Developmental Disabilities. 11(2):219-230

Lelord, G et al (1982) Clinical and biological effects of high doses of vitamin B6 and magnesium on autistic children. Acta Vitamiologica et Enzymologica. 4(1-2):27-44

Lucarelli, S et al (1995) Food allergy and infantile autism. Panminerva Medica. 37:3:137-141

Marshall, F (2006) Living with Autism. London, Sheldon Press.

Martineau J. at al (1987)Developmental changes in event-related-potentials and monoamine metabolites in normal, mentally retarded and autistic children. Current Trends in Event-Related Potential Research, (EEG Suppl. 40), pp. 609-616

Martineau, J et al (1981) Effects of vitamin B6 on averaged evoked potentials in infantile autism. Biological Psychiatry. 16(7):627-641

Martineau, J et al (1982) Comparitive effects of oral B6 Mg and Mg administration on evoked potentials conditioning in autistic children. Event-related potentials in children. New York: Elsevier Biomedical Press 411-416.

Martineau, J et al (1985) Vitamin B6, magnesium and combined B6-Mg:therapeutic effects in childhood autism. Biological Psychiatry. 20(5):467-478

Martineau, J et al (1986) Long term effects of combined vitamin-B6 magnesium administration in an autistic child. Biol Psychiatry. 21:511-518

Martineau, J et al (1988) An open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment. Journal of Autism and Developmental Disorders. 18(3):435-447

Martineau, J et al (1989) Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behaviour. Developmental Medicine and Child Neurology. 31(6):721-727

Menage, P et al (1992)CD4+Cd45RA+ T-lymphocyte deficiency in autistic children: effect of a pyridoxine-magnesium treatment. Brain Dysfunction. 5(5-6):326-333

Mercola, J (2002) Good Bacteria May Relieve Autism Symptoms [Internet], USA. Available from: <http://www.mercola.com/2004/may/26/good_bacteria_autism.htm> [Accessed 10th December 2006]

Moreno, H (1992) Clinical heterogeneity of the autistic syndrome. A study of 60 families. Invest Clin. 33:13-31

Nye, C and Brice A (2006) Combined vitamin B6-magnesium treatment in autism spectrum disorder (review). The Cochrane Collaboration http://www.thecochranelibrary.com

Panksepp, J (1979) A neurochemical theory of autism. Trends in NeuroSciences. 175-177

Patrick, L and Salik, R (2005) The effect of essential fatty acid supplementation on language development and learning skills in autism and Asperger’s Syndrome. Autism and Asperger’s Digest. p36-37

Pfeiffer, CC (1978) Zinc and Other Micronutrients. USA Keats Pub Inc.

Pfeiffer, CC, Iliev, V, Goldstein, L and Jenney, EH (1969) Serum polyamine levels in schizophrenia and other objective criteria of clinical status. In Siva Sankar (Ed) Schizophrenia current contents and research (pp 557-563). Hicksville, NY, PJD Publications

Pfeiffer, SL et al (1995) Efficacy of vitamin B6 and magnesium in the treatment of autism: A methodology review and summary of outcomes. Journal of Autism and Developmental Disorders. 25(5):481-493

Reichelt, KL et al (1981) Biologically active peptide-containing fractions in schizophrenia and childhood autism. Advances in Biochemistry and Psychopharmacology. Vol. 28:627-643

Reichelt, KL et al (1991) Probable etiology and possible treatment of childhood autism. Brain Dysfunction. Vol. 4:308-319

Reichelt, KL, Edminson, PD, Toft, KG (1985) Urinary peptides in schizophrenia and depression. Stress Medicine. Vol. 1(3): 169-182

Reichelt, KL, Ekrem, J and Scott, H (1990) Gluten, milk proteins and autism: dietary intervention effects on behavior and peptide secretion. Journal of Applied Nutrition. Vol. 42(1):1-11

Richardson, A (2003) Fatty Acids in Dyslexia, Dyspraxia, ADHD and the Autistic Spectrum [Internet], Oxford, UK. Available from: < http://www.fabresearch.org/ view_item.aspx?item_id =456&list_id=list1-253&list_index=3> [Accessed 29th April 2007]

Richardson, AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. International Review of Psychiatry. 18(2):155-172

Richardson, AJ and Montgomery, P (2005) The Oxford-Durham study: A randomised controlled trial of fatty acid supplementation in children with developmental coordination disorder. Pediatrics. 115, 1360-1366

Richardson, AJ et al (2003) Clinical and biochemical fatty acid abnormalities in dyslexia, dyspraxia, and schizotypy: An overview. Phospholipid spectrum disorders in psychiatry and neurology, pp477-490. Carnforth: Marius Press

Rimland B. Seizures, Vitamin B6, DMG, and Sudden Speech. Autism Research Review International. 1996;10(2):1.

Rimland, B (1973) High dosage levels of certain vitamins in the treatment of children with mental disorders. Orthomolecular psychiatry: treatment of schizophrenia. San Francisco, CA: WH Freeman

Rimland, B (2002) Vaccinations: The Overlooked Factors [Internet] San Diego, USA. Available from: <http://www.autismwebsite.com/ari/newsletter/vaccinations.htm> [Accessed 10th December 2006]

Rimland, B (2005) Vitamin C in the Prevention and Treatment of Autism [Internet], San Diego, USA. Available from: <http://www.autisme.net/vitaminc-uk.html> [Accessed 10th December 2006]

Rimland, B (2006) Nutritional Treatment for Autism: The History [Internet], USA. Available from: <http://www.latitudes.org/articles/autism_history.html> [Accessed 4th December 2006]

Rimland, B (2006) Nutritional Treatment for Autism: The History by Bernard Rimland [Internet], Tarpon Springs, USA. Available from: <http://www.latitudes.org/articles/autism_history.html> [Accessed 10th December 2006]

Rimland, B, Callaway E, Dreyfus, P (1978) The effect of high doses of vitamin B6 on autistic children: a double blind crossover study. American Journal of Psychiatry. 135(4):4720475

Rimland, B. (1998) High dose vitamin B6 and magnesium in treating autism: response to study by Findling et al. Journal of Autism and Developmental Disorders. Vol. 28(6):580-581

Rimland, B., & Edelson, S.M. (2005). Parent ratings of behavior effects of biomedical interventions (Pub. 34, Rev. March 2005). San Diego: Autism Research Institute.

Rona, ZP (2001) Altered Immunity and the Leaky Gut [Internet], USA. Available from: <http://www.autisminfo.com/leakygut.htm> [Accessed 10th December 2006]

Rossi, P et al (1990) Effects of vitamin B6 and magnesium therapy in autism. Conference on the neurobiology of infantile autism. Tokyo, Japan, Nov 10-11.

Shattock, P and Whiteley P (2000) The Sunderland Protocol - a logical sequencing of biomedical interventions for the treatment of autism and related disorders. Autism Research Unit, University of Sunderland

Shattock, P and Whiteley, P (2002) Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opinions in Therapy Targets. Vol. 6(2):175-183

Shattock, P et al (1990) Role of neuropeptides in autism and their relationships with classical neurotransmitters. Brain Dysfunct. 3:328-345

Simopoulos, AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56:365-379

Sponheim, E et al (2006) High functioning autism and urine peptide patterns. Medisin og Vitenskap. 126:1475-1477

Stevens, L.J., Zentall, S.S., Abate, M.L., Kuczek, T., & Burgess, J.R. (1996). Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiology and Behavior. 59(4/5), 915-920.

Stordy, J. (2000). Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. American Journal of Clinical Nutrition. 71(1), 323-326.

Supplement News (2007) Conjugated Linoleic Acid Introduction [Internet], Oregon, USA. Available from: < http://supplementnews.org/conjugated-linoleic-acid/ > [Accessed 29th April 2007]

The Feingold Association (2006) The Feingold Program [Internet] Riverhead, USA. Available from: <http://www.feingold.org> [Accessed 10th December 2006]

The Henry Spink Foundation (2006) Magnesium [Internet], London SE1 Available from: <http://www.henryspink.org/details.asp?id=15> [Accessed 22nd April 2007]

The Vitamin C Foundation (2006) The Vitamin C Foundation [Internet], Texas, USA. Available from: <http://www.vitamincfoundation.org> [Accessed 10th December 2006]

Tolbert, L, et al (1993) Brief Report: Lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium. Journal of Autism and Developmental Disabilities. 23(1):193-199.

Trattler, R (1985) Better Health Through Natural Healing. New York, Thorsons.

Trevarthen, C et al (1998) Children with Autism: Diagnosis and Interventions to Meet Their Needs. London, Jessica Kingsley Publishers.

Vancassel, S et al (2001) Plasma fatty acid levels in autistic children. Prostaglandins Leukotrienes and Essential Fatty Acids. 65(1), 1-7

Vojdani, A et al (2002) Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, chlamydia pneumoniae and streptococcus group A. Journal of Neuroimmunology. 129:168-177

Vojdani, A et al (2004) Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutritional Neuroscience. 7:3:151-161

Whiteley, P et al (1999) A gluten-free diet as an intervention for autism and associated spectrum disorders: preliminary findings. Autism Research Unit, University of Sunderland

Whiteley, P et al (1999)Preliminary findings from the implementation of a gluten free diet with children with autism and associated spectrum disorders. Autism Research Unit, University of Sunderland

Whiteley, P et al (2000) Dietary intervention in autism: A preliminary look at five case studies suggestive of positive outcome following a gluten-free diet. Autism Research Unit, University of Sunderland

Wilkinson, LD and Dourish, CT (1991) Serotonin and Animal Behaviour, In: Peroutka, S ed, Serotonin Receptor Subtypes: Basic and Clinical Aspects (Wiley, New York), pp 147-210

Wing, L (1976) Diagnosis, clinical description and prognosis. In L Wing (ed) Early Childhood Autism: Clinical, Educational and Social Aspects. New York: Pergamon Press.

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