Opsomycetin Drugs Information

Opsomycetin

Description:

Opsomycetin (Chloramphenicol) was originally isolated from Streptomyces venezuelae. This was the first discovered broad spectrum antibiotic. Opsomycetin is effective for general clinical use and is found to be of therapeutic value in a variety of bacterial infections.

Indications:

  • Typhoid and para-typhoid
  • Severe bacillary dysentry
  • Chronic urinary tract infections
  • Bacterial meningitis
  • Osteomyelitis
  • Septicaemia

Dosage:

  • Adults: usual oral does is 1-2 capsules 6 hourly. In severe infections the does can be increased to 4 gm daily in divided doses.
  • Children: 25-50 mg/kg/day divided into 4 doses at 6 hours interval. In severe infections the does can be increased to 80-100mg/kg/day.

Precautions:

  • The drug should be discontinued after appearance of anaemia, leukopenia, thrombooytopenia
  • The dosage should be adjusted accordingly in case of impaired liver or kidney function.
  • Regular blood studies should be done during chioramphenicol therapy

Side-effects:

Aplastic anaemia, vacuolation of erythroblast, optic neurities, rashes, nausea, vomiting and diarrhoaa may occur occur occasionally during its use.

Contraindications:

Opsomycetin is contraindicated where a history of previous hypersensitivity to chioramphenicol is established. it must not be used in the treatment of trivial infections or during pregnancy.

Presentation:

  • Opsomycetin capsule: Each capsule contains 250 mg of Chioramphenicol BP.
  • Opsomycetin Suspension: Each teaspoonful (5ml) contains Chioramphenicol Paimitate BP equivalent to 125 mg of Chioramphenicol.

Packing:

  • Opsomycetin capsule: Cartons of 10*10 capsules in blister strips.
  • Opsomycetin Suspension:Bottles of 60 ml.

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