Ovarian Cancer -Is Not Silent

What is Ovarian Cancer

Ovarian cancer is a cancer that forms in the tissues of one of the ovaries, which are the reproductive glands of women where the ova or eggs are formed and ovarian cancer was thought to be the silent killer for many years.

Ovarian cancers tend to be either ovarian epithelial carcinomas (which are cancers that begin on the surface of the ovary) or malignant germ cell tumors (which are cancers that begin in the egg cells). In 2012, there will be 22,280 new cases resulting and 15,600 deaths, which accounts for approximately 3% of all cancers in women. It is the ninth most common cancer among women but the fifth leading cancer related death among women, and the deadliest gynecological cancer. Caucasian women have slightly higher death rates than minority women.

Ovarian Cancer Ribbon

Source

Ovarian Cancer Risk Factors and Testing

The one risk factor you cannot change of course is your genetic makeup. If you have a history in your family of breast, ovarian or colon cancer, you are at higher risk. The more relatives you have with these types of cancers, the greater your risk and you may want to consider genetic counseling.

There are two types of blood test that can be done to determine if you have a higher risk of getting ovarian, breast, prostate or other types of cancer.

BRCA1 This test looks for certain mutations found in a gene on chromosome 17, which normally helps to suppress cell growth. These mutations carry a higher risk of getting breast, ovarian, prostate and other cancers as well.

BRCA2 A person that inherits certain mutations on this gene found on chromosome 13, which normally also suppresses cell growth has a higher risk of getting breast, ovarian, prostate and other types of cancers also.

Normally these cells ensure the stability of the cell's genetic material preventing cell growth but the mutations of these genes has been particularly length to the development of hereditary breast and ovarian cancer . A woman's lifetime risk if she inherits these mutations is markedly increased for women before menopause and often multiple family members may have been diagnosed with these diseases. They also increase the risk of a woman developing cervical, uterine, pancreatic and colon cancer with the BRCA1 mutation. The BRCA2 mutation may in addition increase the risk of pancreatic cancer, stomach cancer, gallbladder and bile duct carcinoma, plus melanoma.

Men with the BRCA1 mutations have an increased risk of breast cancer and possibly of pancreatic cancer, testicular cancer and early onset prostate cancer, however, these cancers appear to be more strongly associated with the BRCA2 mutations.

BRCA testing may be expensive but many insurance companies will pay for this testing when you have a strong family history, so it's advisable to check with your insurance company first before having a testing.

A friend of mine who shares my love for genealogy found a malignant lump in one breast and because she has a strong history of cancer in her family history she had a double mastectomy. She also had genetic counseling and her BRCA tests were negative. As she worked on the genealogy she found that many ancestors had died of cancer. She has a large family with numerous cousins She started informing the relatives about the BRAC test and two women were diagnosed with breast cancer and one man with colon cancer due to having a positive BRCA test, but they had been asymptomatic up until this test. Genetic counseling is worthwhile if you have a strong family history of cancer.


Symptoms of Ovarian Cancer and Tests

The average age for diagnosis is 63 and the average age for death from ovarian cancer is 71. However, 5% of women are diagnosed under the age of 34. Ovarian cancer was considered the silent disease because it was thought that there were no noticeable symptoms and quite often it is not caught in the early stages.

Fewer than 20% of ovarian cancers are caught in stage I but that is when they are the most treatable with the highest survival rate (70 to 90% survive). Most women have progressed to stage III before they are diagnosed.

It is most imperative that women pay attention to the signs of ovarian cancer to save their lives. Women often notice several symptoms that they either ignore or write off as having some other cause

  1. One of the most common symptoms is abdominal bloating and increased abdominal girth.
  2. Frequent or urgent urination is also quite common.
  3. Pelvic or abdominal pain (or pain with intercourse) is also a symptom not to be ignored.
  4. Many women have either difficulty eating or a sense of feeling full very quickly.

If you'd notice severe bloating in your abdomen and an increase in your abdominal girth which occurs almost every day and lasts for more than 2 to 3 weeks, it is important to get to your doctor for medical testing. Pelvic pain lasting for 2 to 3 weeks is also a concern but does not always occur with ovarian cancer. The appetite changes happen when the ovaries release chemicals that slow down the gut, thus increasing the time it takes for food to work its way through your body.

If you have frequency of urination it may be a symptom of a UTI, which you would want to check out first with your doctor but if it lasts beyond medical treatment for 2 to 3 weeks, than other reasons for the urgent urination need to be explored.

Beginning testing for ovarian cancer includes:

  1. Transvaginal ultrasound.
  2. Recto vaginal exam, which allows the physician to feel the ovaries more effectively.
  3. C125blood test assay which measures a protein or substance that ovarian cancer excretes into the blood as a tumor marker. However, it is not elevated for all women who have ovarian cancer.
  4. Lowers GI's series or barium enema.
  5. Ultrasounds are not recommended for routine testing unless you are at high risk.

Ovarian Cyst

Many women have ovarian cyst, which may be found inside or outside of an ovary. Cysts have fluid and also some solid tissue as well but are usually benign. Usually they go away over time but occasionally a doctor will find in the cyst gets larger and test will be done to make sure that it's not cancerous.

Normal ovaries

Source

Cancerous Mass on the Left Ovary

Hormone Therapy

In Denmark, 910,000 women underwent a nationwide study to correlate developing ovarian cancer with women who had used hormone therapy through menopause. The findings confirmed previous studies which indicate ovarian cancer should be considered when doctors are prescribing hormones.

In 2002, the Women's Health Initiative reported that a combination hormone therapy of estrogen plus progestin increased the risk of breast cancer, but estrogen alone increases the risk of ovarian cancer.

Ovarian Cancer Prevention

There are no FDA approved ways to prevent ovarian cancer.

There are some doctors that state certain foods will help prevent ovarian cancer and they include endive, which is used in salads and is thought to reduce your risk of cancer by 75% if you we eat a half cup two times a week. There was a study done in Europe that showed eating Sea Bass, which contains omega-3 fatty acids helps reduce your risk by 30% if you eat 6 ounces 2 to 3 times per week. Onions contain at least four different cancer fighters according to studies done in Italy and Switzerland and can reduce ovarian cancer by 73% if red onions are used. Other cancer fighters include garlic, capers, olives, lemon juice, which contains a cancer fighter called lemondine,and tomatoes. Obviously eating healthy, not smoking, exercising and getting enough rest will reduce your risk of getting any type of cancer.

Ovarian Cancer Symptoms

Ovarian Cancer Treatment

In the advancing stages of ovarian cancer the problem is the cancer can attack, shed or break off and travel to other organs. An ovarian tumor may grow and invade an organ next to the ovary, such as the fallopian tubes or uterus. Cancer cells can also shed or break off from the main tumor into the abdomen and form new tumors on the outside of other organs and tissues. They are sometimes called seeds or implants. Furthermore, cancer cells can multiply through the lymphatic or blood into the abdomen or chest, which can affect other organs such as the liver or lungs.

I have a dear friend who has stage IV ovarian cancer and is undergoing another round of chemotherapy following years of treatment and periods of remission. This time she has three new tumors and one of them is quite large, so they are using radiation and this new chemotherapy to hopefully save her life. She told me that she thought something was wrong well before she was diagnosed as she had the symptoms of bloating,and a change in her appetite, but she never dreamed it was cancer. By the time she was diagnosed she was already in stage III, however, persistent treatment has kept her alive for several years. I pray for this precious friend daily as she has fought a long, hard battle that I hope she will win.

Of course the goal of treating ovarian cancer is to remove or kill as much of the cancer as possible, which may involve simple or radical surgery, chemotherapy, radiation or any combination of the above. Most commonly the surgeon will remove the ovaries, the uterus and the fallopian tubes, then chemotherapy will begin. They have improved chemotherapy drugs today with less side effects and the chemotherapy will be chosen according to your grade and type of ovarian cancer. If you also require radiation it will target the cancer cells much more effectively than radiation of the past and not damage as many healthy cells.

Summary

I cannot emphasize too much how important it is to pay attention to any physical symptoms in your body that are suddenly different even over just a two-week period of time. It is better to go see your physician and be told you're cancer free and take a risk that nothing is really wrong.

© 2011 Pamela Oglesby

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Comments 25 comments

anglnwu profile image

anglnwu 5 years ago

Wow, what a thorough coverage of ovarian cancer. Thanks for providing us with the symptoms--like you said, it's important to listen to our body and consult with the doctor when in doubt. Awesome!


Happyboomernurse profile image

Happyboomernurse 5 years ago from South Carolina

This is another excellent, well documented and comprehensive hub.

Thanks for sharing this valuable information about possible symptoms that may yield the first clue that a woman has ovarian cancer and aid in earlier diagnosis.

Sorry to hear of your friend's ongoing struggle. I will say a prayer for her.


TheManWithNoPants profile image

TheManWithNoPants 5 years ago from Tucson, Az.

Very well put together. I've lost three friends and my mother to cancer in the past four years. We've got to get on top of this awful disease. Voted up. awesome, and interesting!

jim


Cardisa profile image

Cardisa 5 years ago from Jamaica

A very comprehensive hub on ovarian cancer with some very useful information. I had my ovaries removed when I did my hysterectomy. The surgeons thought it would be better to remove all my reproductive organs to reduce the risk of any kind of cancer especially down there. I am not on any estrogen therapy either. I just drink a lot of soy milk and eat healthy.


Cloverleaf profile image

Cloverleaf 5 years ago from Calgary, AB, Canada

Hi Pamela,

I appreciate all this valuable information you have shared in this hub. I had a scare a couple of years ago and so getting regular checkups and knowing what to look for is vital. Very interesting, voting up.

Cloverleaf.


thranax profile image

thranax 5 years ago from Rep Boston MA

Good Hub. It is something to be wary of. Every time I read or think of Ovarian cancer my ovaries hurt. The problem with that is I dont have any im a male.

~thranax~


Pamela99 profile image

Pamela99 5 years ago from United States Author

anglnwu, I'm glad you found the article helpful and I very much appreciate your comments.

Happyboomernurse, Thank you for your comments and I appreciate your prayer.

Themanwithnopants, I'm sorry to hear about your loss and you're right we do need to get on top of these cancers. That is why I wanted to really emphasize early detection for this particular cancer. Thank you for your comments.

Cardisa, You have certainly lowered your risk for any type of female cancer. I appreciate your comments.

Cloverleaf, I am glad you are well and I appreciate your comments.

thranax, I like your comment and knowledge is power so it's good to be aware of symptoms of any type of cancer. Thank you for your comments.


Cassie Ann profile image

Cassie Ann 5 years ago

Pamela - thanks so much for this informative hub. Voted up definitely.

Sometimes I think about what may be growing inside us without our knowledge. You listed very helpful symptoms to look for. My cousin died of ovarian cancer in her early 40's.

I will pray for your friend.

Cassie


Pamela99 profile image

Pamela99 5 years ago from United States Author

Cassie Ann, Thank you so much for your comments and I appreciate the prayers.


shazwellyn profile image

shazwellyn 5 years ago from Great Britain

Thank you for explaining a rather complex disease so effectively and well. This is a quality article which many people will benefit from. Great writing, Pamela!


MartieCoetser profile image

MartieCoetser 5 years ago from South Africa

Pamela, your the best! Honestly, there is no one on the entire Internet able to explain medical issues as well as you do. I've bookmarked this one. One of my grandmothers had died at the age of 84 from Ovarian Cancer.


Pamela99 profile image

Pamela99 5 years ago from United States Author

shazwellyn, Thank you so much for your comments.

Martie, That is a very nice complement. I appreciate your comments.


always exploring profile image

always exploring 5 years ago from Southern Illinois

Ovarian Cancer is deadly due mostly to late symptoms. Thank you for a well written article. I agree with Martie......


drbj profile image

drbj 5 years ago from south Florida

Your comprehensive and well-written hub on Ovarian cancer could well save some woman's life, Pamela. Thank you for your extensive research and explanations.


Nell Rose profile image

Nell Rose 5 years ago from England

Hi, My friend died back in 2003 with Ovarian Cancer, as you said, she never noticed the first symptoms and in fact the hospital kept putting her off of going for her checkups because of over crowding! this is a really detailed hub and so important, nell


Pamela99 profile image

Pamela99 5 years ago from United States Author

always exploring, I agree. I appreciate your comments.

drbj, I hope you are right that women will understand and act if they get the symptoms of ovarian cancer. Thank you so much for your comments.

Nell Rose, I'm sorry to hear about your friend. That really speaks to the necessity of getting help as soon as you get any symptoms and demanding medical treatment. Thank you for your comments.


prasetio30 profile image

prasetio30 5 years ago from malang-indonesia

Hi, Pam! How are you today? I hope you always fine and healthy as well. Thanks for always share useful information about health. I'll show this to my sister and my mom also. The most important thing is we know this early before too late. Keep on posting. I will always wait your next hub. VOTE UP and UP!

Prasetio


Pamela99 profile image

Pamela99 5 years ago from United States Author

prasetio, I am always glad to see you and hope your mother and sister will find this hub helpful. I am fine and hope you are also. Thank you for your comments.


Coolmon2009 profile image

Coolmon2009 5 years ago from Texas, USA

I enjoyed reading this well documented and comprehensive article. Although I can't think of anyone in my immediate circle of friends and family that have the symptoms of Ovarian cancer, I will forward this link to the ladies I know. Good article!


Pamela99 profile image

Pamela99 5 years ago from United States Author

Coolman, Thanks so much for your comments.


drpastorcarlotta profile image

drpastorcarlotta 5 years ago from BREAKOUT MINISTRIES, INC. KC

As always Pamela99 you have health information for us that is useful and informational! I love coming to your Hubs and reading! Much love.... Voted-Up, and Useful!!!!


Pamela99 profile image

Pamela99 5 years ago from United States Author

drpastorcarlotta, I'm glad you appreciated the hub and I appreciate your comments.


PegCole17 profile image

PegCole17 5 years ago from Dallas, Texas

This will undoubtably help save lives, Pamela. Very informative and well written. I enjoyed the illustrations too. Some of these health concerns have been on my mind lately that I'm inspired to look into now. I'm sorry to hear of your friend who is battling this disease. My best hopes for her improved health and yours as well.


Pamela99 profile image

Pamela99 5 years ago from United States Author

PegCole, I am glad you found the hub helpful and appreciate the good wishes for my friend. Thanks for all your comments.


Pamela99 profile image

Pamela99 5 years ago from United States Author

PegCole, I am glad you found the hub helpful and appreciate the good wishes for my friend. Thanks for all your comments.

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