Stem Cells Treat Multiple Sclerosis

Stem Cells Treatment for MS

Stem cells treat Multiple Sclerosis effectively in several clinical trials around the world. They not only stop the progression of the disease but are able to reverse nerve damage. Up until now the only treatment for MS slowed the progression of the disease and alleviated associated symptoms. Cures for Multiple Sclerosis have been non-existent until now. Finally, there are several drugs that are being studied and should be on the market soon according to the Multiple Sclerosis Society plus the stem cell therapy holds great promise. These medications will hopefully be effective in providing a better quality of life, but they aren’t likely to be as effective as stem cell therapy.

Brain Neuron

Photo Courtesy of Wickipedia
Photo Courtesy of Wickipedia
Photo Courtesy of Google
Photo Courtesy of Google

MS-the Disease and Symptoms

Multiple Sclerosis is an autoimmune, chronic neurological disease affecting the central nervous system (which includes the brain and spinal cord) by causing inflammation and damage to myelin (which is the insulation tissue for nerve fibers) and in other cells within the nervous system. The job of the myelin is to conduct nerve signals, so when the myelin is damaged the results may impair normal sensation, movement and thinking. The damage occurs in patches as distinct lesions, so individuals may have different symptoms depending on the location of these lesions.

Initially the symptoms of MS are often transient, mild and self limited. The typical signs and symptoms of MS will vary slightly in different individuals, but the most common ones are changes in sensation, muscle weakness, abnormal muscle spasms, difficulty moving, coordination and balance, speech problems, difficulty swallowing, visual problems, fatigue, acute or chronic pain, bladder and bowel difficulties, cognitive impairment or emotional problems, with depression understandably a problem. This is quite a lot for an individual or even their caretaker to contend with and a stem cell cure would be a miracle for these individuals. Multiple Sclerosis diagnosis occurs with evaluation of symptoms, then a spinal tap. There is no diagnostic blood test.

Collecting Bone Marrow From Hip

Photo Courtesy of Cell Center in Germany
Photo Courtesy of Cell Center in Germany

Research in Germany

Photo Courtesy of Cell Center working with stem cells, Germany
Photo Courtesy of Cell Center working with stem cells, Germany

Stem Cell Transplant

Stem cell transplantation for MS step by step as described in a German hospital:

  • Physicians take some bone marrow stem cells from the iliac crest bone in the hip and keep the cells alive. It takes about 30 minutes to complete the procedure and it is not particularly painful.
  • Stem cells are processed from the bone marrow in a state-of-the-art government approved laboratory. Both quality and quantity of the stem cells is measured. “Thesecells have the potential to transform into multiple types of cells and are capable of regenerating or repairing damaged tissue.”
  • While the German study did not mention this, it was a part of the procedure in the American study with the other steps being identical. They use chemotherapy to essentially wipe out your immune system.
  • Next they put the stem cells back into the body by lumbar puncture which puts them into cerebrospinal fluid and transports them up the spinal canal to the brain.
  • These new stem cells no longer see the myelin as invader, so they do not attack the myelin sheath.
  • The body then can get to work healing any early-stage multiple sclerosis damage.

Study Results

In this study 50 patients with MS were treated and returned questionnaires. The mean age was 48 and the follow-up was 5 months later. The results were improvement in 25 patients, no disease progression in 18 patients, and natural progress of disease in only 7. The ability to walk better without help and stand alone was reported by 50% of the patients. Improved visual acuity improved in 57.1%. Enhanced bladder control and bowel control improvement was reported at 47.1% ad 28.6%.

In the American study 23 patients, all with early stage relapsing-remitting MS were treated. They have tried the procedure before in late stage MS and the results were not encouraging. After this procedure the group was followed for 3 years and 17 of them improved by at least 1 point on the disability scale and none got worse. The disability scale is designed especially for MS patients and include things like balance, walking, bladder and bowel control, etc.

Stem cell Research

Multiple Sclerosis Adult Stem Cell Therapy

Summary with New Hope for the Future

There is now a larger trial underway. They want to learn more about risks and benefits or treatment and at precisely at what stage is this procedure most beneficial. Just to clarify the stem cells uses, the process is called autologous non-myeloablative haemopoietic stem cell transplantation, which simply means that a person’s own adult stem cells are used and the chemotherapy doesn’t fully destroy the bone matter. So, this procedure is an autologous bone marrow transplant.

This is an exciting new procedure that promises possible cures particularly when the disease is found in its early stages. Numerous countries with out best top scientist are now treating these patients with stem cells and having positive results. This procedure is actually healing not just slowing down the process of the disease. Stem cells treat Multiple Sclerosis during early stages of the disease is by far the best way to help an individual live a full, normal healthy life. Stem cells for treating Multiple Sclerosis are the most exciting advance in an otherwise debilitating disease

© 2010 Pamela Oglesby

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Comments 40 comments

Roberta99 profile image

Roberta99 6 years ago

Amazing what research can do. Veery interesting.


Mentalist acer profile image

Mentalist acer 6 years ago from A Voice in your Mind!

Now there's hope for my brother who has this desease and wish they could speed things up,what Bush did to stem-cell research was an early death and disabling existence for my brother Dale;)


Tom Whitworth profile image

Tom Whitworth 6 years ago from Moundsville, WV

Pamela,

Thank you for the information on the progress on this horrid disease!!!!

I have one question, since it is hard to diagnose, is there a better diagnostic proceedure, or a genetic predictor?


Pamela99 profile image

Pamela99 6 years ago from United States Author

Roberta, thanks for your comment.

Mentalist Acer, I am so sorry to hear about your brother. They must still be painful and difficult to share. Thanks for sharing your personal experience.

Tom,

I did not read about a genetic predictor but I that is a possibility as they are doing that with so many diseases. The diagnosis procedure seems to happen if a patient as 2 unusual episodes like those I listed, then they get a lumbar puncture that confirms or denies the diagnosis. Thanks for your comments.


msorensson profile image

msorensson 6 years ago

Great hub, Pamela, you did a fantastic job. Hugs, Melinda


Pamela99 profile image

Pamela99 6 years ago from United States Author

Msorensson, I appreciate your comments.


K9keystrokes profile image

K9keystrokes 6 years ago from Northern, California

My cousin has this this monster disease. I am greatful that you took on the subject Pamela. You did a wonderful job with it.

K9


Pamela99 profile image

Pamela99 6 years ago from United States Author

K9keystrokes, I hope your cousin can get on one of the new medications that will soon be a available or better yet a stem cell transplant. I can't even imagine how difficult it must be to live with this disease. Thanks for your comment.


"Quill" 6 years ago

Hi Pam... wonderful Hub and one packed with good news for those who suffer...

Blessings and Hugs


carolina muscle profile image

carolina muscle 6 years ago from Charlotte, North Carolina

Another very well researched hub... nicely done, Pamela!!


Pamela99 profile image

Pamela99 6 years ago from United States Author

Quill, I appreciate you comments very much. Blessings and Hugs to you and yours also.

Chris, Thank you so much for your kind comments. They are appreciated.


JY3502 profile image

JY3502 6 years ago from Florence, South Carolina

You are an amazing writer Pamela. Good job.


Pamela99 profile image

Pamela99 6 years ago from United States Author

JY3502, Thank you for the compliment and I am glad you stopped by to read my hub.


akirchner profile image

akirchner 6 years ago from Central Oregon

It is amazing what they are doing with stem cells and I hope they can find a cure for this terribly debilitating disease - among others! Great piece, Pamela.


billyaustindillon profile image

billyaustindillon 6 years ago

Pamela super research here on MS and stem cells with the images and vision - awesome!


Pamela99 profile image

Pamela99 6 years ago from United States Author

Audry, It is fascinating and holds such hope for the future for many diseases. Thanks for your comment.

Billy, I really appreciate your comments.


Eileen Hughes profile image

Eileen Hughes 6 years ago from Northam Western Australia

Great helpful and very much hopeful hub, this will give much hope to MS sufferers that's for sure. Thanks for sharing this research


Jen's Solitude profile image

Jen's Solitude 6 years ago from Delaware

Great info Pam! It would be wonderful if those newly diagnosed with MS could stop progression or better yet cure the disease before it takes over. As for me, 17 years in, I am still hopeful that one of the oral drugs will be helpful. At the very least, it will mean no more worries about daily injections, which will be a HUGE relief! LOL Thanks for presenting these findings in such a clear and easy to understand manner!


Hello, hello, profile image

Hello, hello, 6 years ago from London, UK

That is such wonderful news. Thank you for doing all this research and writing this wodnerful hub.


Wendy Krick profile image

Wendy Krick 6 years ago from Maryland

Science has come a long way. Great hub!


JannyC profile image

JannyC 6 years ago

Fascinating Hub. Amazing too how we are able to discover this. It surely was not over night so kudos to all the researchers tiredless efforts.


Pamela99 profile image

Pamela99 6 years ago from United States Author

Eileen, I hope it does help people and thank you so much for your comments.

Jen, I hope the hub was helpful to you. I didn't know you had MS and maybe one of these new medicines will be the answer. I hope so. Thanks for your comments and I wish you good health.

Hello, Thanks for your comment also.

Wendy, I appreciate your comments.

Janey, I imagine it took many hours of research. Thanks for your comment.


dallas93444 profile image

dallas93444 6 years ago from Bakersfield, CA

Great comments! Exciting future...


Pamela99 profile image

Pamela99 6 years ago from United States Author

Dallas, Thanks for your comment.


Springboard profile image

Springboard 6 years ago from Wisconsin

Like most of the terrible diseases that plague us, one day I hope we can find cures for them all. Great job on the hub Pamela.


Pamela99 profile image

Pamela99 6 years ago from United States Author

Springboard, I hope so too. I have hope that the DNA work will really cure some of the worst ones because when you are using a person's DNA from their hip, they are not going to reject it. Thanks for your comment.


habee profile image

habee 6 years ago from Georgia

Wow! This is exciting news for those who suffer from MS!


Pamela99 profile image

Pamela99 6 years ago from United States Author

Habee, It is good news. Thanks for your comment.


bujju profile image

bujju 6 years ago

Thanks for the great information you provided,


Pamela99 profile image

Pamela99 6 years ago from United States Author

bujju, Thank you so much for your comment.


Support Med. profile image

Support Med. 6 years ago from Michigan

This is truly amazing. Actually reversing/healing MS!! Not just slowing the process! It's news like this that makes me glad about stem cell research (most times I'm not so certain how I feel about it); but this is awesome!! Hopefully, all who are diagnosed early will receive benefit of it. Voted/rated.


Pamela99 profile image

Pamela99 6 years ago from United States Author

Support Med, It is exciting to thing people can be cured of this horrible disease. Thanks for your comments.


jasper420 6 years ago

intresting aned well writtin nicly done i learneed a lot about ms while reading your hub i didn't know it was such a devistaing dease thankyou for opinong my eyes and allowing me to see how lucky iam


Pamela99 profile image

Pamela99 6 years ago from United States Author

Jasper, I am glad you enjoyed the hub. Thanks for your comments.


nancy_30 profile image

nancy_30 6 years ago from Georgia

Very informative hub. I learned a lot from your hub. Thank you for sharing all of this information.


Pamela99 profile image

Pamela99 6 years ago from United States Author

Nancy, I am glad you enjoyed the hub and thank you for your comments.


ncuxapa_ profile image

ncuxapa_ 5 years ago

Unfortunately, stem cells have very usage and one of the is this one


Pamela99 profile image

Pamela99 5 years ago from United States Author

nceuxapa, It is very fortunate for people with multiple sclerosis that stem cells are helping with their disease. Hopefully they will treat more diseases in the future.


conradofontanilla profile image

conradofontanilla 4 years ago from Philippines

I have made the conclusion that so-called autoimmune disease is one that is caused by free radicals. In biomedicine, autoimmune is explained further as the immune system being "confused" (by Dr. Dean Ornish in his book on Reversing Heart Disease) and "misidentify" (in Your Heart, edited by Dr. Clayman) but these concepts could not be verified. Dr. Ornish uses the term "confused" in the framework of dialectics, as if looking at one-self and not one-self. Free radicals are indiscriminate capable of killing both cancer and healthy cells in the vicinity of cancer cells, for example. This could be the reason for its being confused or misidentification of targets. Take Adriamycin. It produces a lot of free radicals that kill both cancer and healthy cells in the vicinity (Sharma, H. Freedom from Disease. 1993). However, biomedicine will not mention about free radicals. Multiple sclerosis is caused by free radicals. It can be treated with natural ingredients, which I discussed in my Hub, a supplement that you can make to treat ms. I am glad stem is into MS. A lot of neurons are made at one time but not all of them are used; some are held in reserve that when those in use conk out the reserves are called to duty. So there might not be an urgent need to rehabilitate damaged myelin or axons but to protect the reserves from free radical damage. Good if stem cell can regrow. them.


Pamela99 profile image

Pamela99 4 years ago from United States Author

confradofontanilla, Thank you for your comments obn MS. I am very familiar with the work of Dr. Dean Ornish and he has proven that you can reverse heart disease by following his program which is amazing.

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