Synthetic 'Marijuana'

Agitation, seizures. psychosis, heart attacks

“Spice” products are synthetic cannabimimetics (SC; also called “synthetic cannabinoids”)-based designer drugs used as a legal alternative to cannabis for their very strong tetrahydrocannabinol (THC)-like effects" - Papanti et al, Advances in Dual Diagnosis 2014

Duccio Papanti at the University of Trieste study results were,

According to "Legal highs linked to psychosis". New Zealand Herald. Apr 5, 2014, instead of banning one version only to have a slightly different pop up as a replacement, NZ scheme is more commonsense than the current 'whack a mole' method done in the United States. The US should adopt and regulate, prior to release to the public, "...requiring them to undergo clinical trials to prove they had no more than a "low risk" of harm."

Cannabicyclohexanol, JWH-018, JWH-073, or HU-210 are dangerous compared to naturally occurring cannabis.

JWH-018 was emergency scheduled into the Schedule I category on March 1, 2011

The following chemical soup became illegal in 2012, "five synthetic cannabinoids 1-pentyl-3-(1-naphthoyl)indole (JWH-018), 1-butyl-3-(1-naphthoyl)indole (JWH-073), 1-[2-(4-morpholinyl)ethyl]-3- (1-naphthoyl)indole (JWH-200), 5-(1,1-dimethylheptyl)-2-(3- hydroxycyclohexyl)-phenol (CP-47,497), and 5-(1,1-dimethyloctyl)-2-(3- hydroxycyclohexyl)-phenol (cannabicyclohexanol, CP-47,497 C8 homologue) including their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible, into Schedule I of the Controlled Substances Act (CSA)." - DEA Diversion

The problem is, "Isomers, or the compounds with the same molecular weights but different structures, are being made every day." - Ling Huang, Ph.D., Assistant Professor of Chemistry

Why Synthetic Marijuana Is More Toxic To The Brain Than Pot

“Clinically, they just don’t look like people who smoke marijuana,” says Lewis Nelson, MD, at NYU’s Department of Emergency Medicine, Division of Medical Toxicology. “Pot users are usually interactive, mellow, funny. Everyone once in a while we see a bad trip with natural marijuana. But it goes away quickly. With people using synthetic, they look like people who are using amphetamines: they’re angry, sweaty, agitated.” - Alice G. Walton Alice G. Walton 8/28/2014 Forbes

John W. Huffman, PhD, one of the chemists who designed synthetic cannabis said that those who tried it must be “idiots." - Marijuana News 8/28/2014

"Using these things is like playing Russian roulette because we don't have toxicity data, we don't know the metabolites, and we don't know the pharmacokinetics." -John W. Huffman, interview with Chemical and Engineering News, 2010 [1]
"Using these things is like playing Russian roulette because we don't have toxicity data, we don't know the metabolites, and we don't know the pharmacokinetics." -John W. Huffman, interview with Chemical and Engineering News, 2010 [1] | Source
JWH-018 can be detected with drug tests from the redwood toxicology laboratory. The test checks for JWH-018 and JWH-073 metabolites in the urine with a window of detection up to 72 hours (depending on usage/dosage).
JWH-018 can be detected with drug tests from the redwood toxicology laboratory. The test checks for JWH-018 and JWH-073 metabolites in the urine with a window of detection up to 72 hours (depending on usage/dosage). | Source

Main reason for use now non-existent.

Toxicology technology has now removed the number one reason to use the designer drugs aka 'cannabinoid research chemicals' because drug testing has now been recently available. ELISA is Enzyme Linked ImmunoSorbent Assay is able to detect JWH-018 and 073 metabolites. It confirms:

  • JWH-018 N-(4-hydroxypentyl) metabolite
  • JWH-018 N-(5-hydroxypentyl) metabolite
  • JWH-073 N-(3-hydroxybutyl) metabolite
  • JWH-073 N-(4-hydroxybutyl) metabolite (source: NMS Labs)

Spiceophrenia

Severe agitation, disorganized thoughts, paranoid delusions, and assaultive behavior is prevalent among admitted JWH over-dosed patients for experiencing psychotic breaks. - Nancy A. Melville, Synthetic Cannabis Triggers 'Spiceophrenia' 12/12/2013

Perhaps that is why it was tested for in the Florida Face-Eater autopsy. The Miami-Dade County ME reported, "The department has also sought the assistance of an outside forensic toxicology reference laboratory, which has confirmed the absence of 'bath salts,' synthetic marijuana and LSD." - Michael Martinez, Tests in cannibalism case: Zombie-like attacker used pot, not 'bath salts' 6/27/2012

Wasn't it a dumb idea to invent this stuff for research purposes in the first place? Invented to supposedly mimic THC for animal testing to prove that Natural weed id dangerous? Couldn't get the real stuff because federally outlawed and made this misfit substitute. Now valid research if testing animals with SC and saying this is what natural weed THC does. It obviously doesn't.

Wasn't it a dumb idea to invent this stuff for research purposes in the first place?

  • No.
  • Yes
  • I'm not sure, I don't know.
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The shocking effects of synthetic marijuana

In Summation

"The synthetic cannabinoids (SC) currently being marketed as alternatives to plant cannabis have a higher risk of adverse outcomes than phyto (plant) cannabinoids" - Paul Dessauer

"We may be on the verge of another ecstasy-like problem, although the relatively easy availability of natural cannabis products worldwide may make abuse of synthetic cannabinoids less profitable" - Jenny L. Wiley, PhD, Julie A. Marusich, PhD, John W. Huffman, PhD, Robert L. Balster, PhD, and Brian F. Thomas, PhD 11/2011

Synthetic Marijuana Added to Defense Departments Drug Tests

Law enforcement discusses synthetic drug effects

K2 (synthetic marijuana) difficult to detect

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