The Key Cause of Diabetes: Low Oxygen in Cells due to Heavy Breathing 24/7

By Dr. Artour Rakhimov (

Presence of chronic overbreathing (or hyperventilation) in people with type 2 diabetes has been found in all 5 studies that measured minute ventilation in groups of people with type 2 diabetes. Overbreathing leads to lowered content of cells oxygen. Recent medical studies claim that tissue hypoxia is the key cause of death of beta-cells in pancreas, reduced insulin production, insulin resistance, and formation of white adipose tissue (fat leading to obesity).

Consider medical evidence related to heavy breathing in diabetes.

Expected effects of chronic deep breathing

First of all, overbreathing reduces oxygenation of the arterial blood. This may sound strange. Indeed, if we breathe more air, we should get more oxygen in the blood. Consider medical facts. Normal breathing provides nearly ideal or maximal possible oxygenation of the arterial blood (roughly 98-99 per cent) because it is diaphragmatic or abdominal. However, people with diabetes are chest breathers. As a result, their lower sections of the lungs do not acquire new air volume with larger oxygen content. Lower lungs get about 6-7 times richer blood supply caused by gravity. These are the most important areas for effective blood oxygenation, and these areas, in diabetics, are dormant.

Next effect of hyperventilation is that we actually cut back amount of carbon dioxide in the arterial blood. This substance is a vasodilator (some studies say the most potent known vasodilator). Low CO2 levels in the blood (called hypocapnia) leads to spasm of blood vessels and reduced blood supply to all vital organs of the human body, the pancreas included.

Furthermore, CO2 is important for release of oxygen to cells. It is called the Bohr effect. Really, large numbers of physiological studies have found that chronic over-breathing lowers oxygen content in the body cells. As a result, the ineffective breathing pattern in diabetics produces deficiency of oxygen or hypoxia in cells.

The above numbers for breathing in diabetics (12-15 liters or air per min) were measured at rest during day time, most likely on an empty stomach. The real picture is much worse, since even ordinary people have worst breathing parameters and lowest body oxygen levels during early morning hours due to so called "sleep heavy breathing effect". In addition, breathing gets heavier after meals. Therefore, they do indeed have heavy breathing 24/7.

As a result, diabetics create low oxygen levels in body cells due to their heavy breathing.

Is cells oxygen important for type 2 diabetes?

Again, let us consider recent medical results. When the oxygen levels in body cells is below the norm, the cells produce hypoxia-inducible factor-1 or HIF-1, a protein that signals tissue hypoxia. This protein regulates function is those pancreatic cells that produce insulin! Here are some titles of medical studies (follow the link to the main diabetes page below to read all these abstracts).

Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE, Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets, Journal of Clinical Investigations, 2010 Jun 1; 120(6): 2171-83. doi: 10.1172/JCI35846.

Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS, HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes, Journal of Physiology, Endocrinology and Metabolism. 2007 Dec; 293(6): E1590-6.

The same chemical is linked with another key problem in diabetes: insulin resistance.

Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE, Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue, Mol Cell Biol. 2009 Aug; 29(16): 4467-83.

Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S, Hypoxia decreases insulin signaling pathways in adipocytes, Diabetes. 2009 Jan;58(1):95-103.

Furthermore, low oxygen levels in cells prevents recovery of cells producing insulin.

Heinis M, Simon MT, Ilc K, Mazure NM, Pouysségur J, Scharfmann R, Duvillié B, Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha, Diabetes. 2010 Mar;59(3):662-9.

Finally, low oxygen levels can even destroy (kill) pancreatic cells.

Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M, Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression, FASEB J. 2002 May;16(7):745-7.

In their conclusions, these doctors wrote, "In conclusion, our data provide convincing evidence that reduced oxygenation is an important cause of beta-cell loss and suggest that HIF-1alpha protein level is an indicator for hypoxic regions undergoing apoptotic cell death. "

Surely, people with type 2 diabetes do need oxygen in cells. How can they get it? They can get more oxygen by breathing slower and lighter, using the diaphragm, 24/7. For criteria of clinical remission and medical treatment of type 2 diabetes, follow the link below.

Resources from

Cystic Fibrosis Prognosis - How body oxygen levels and breathing patterns define symptoms in cystic fibrosis
Diabetes - Its Cause and Proven Medical Treatment
Diabetes Cause: Low Oxygen in Cells due to Heavy Breathing 24/7 - and Why Talking Too Much Undermines Health - Knols by Dr. Artour Rakhimov has hundreds of medical quotes and references, graphs and charts, tables, analysis of numerous respiratory techniques, results of clinical trials, free breathing exercises with lifestyle modules, manuals with techniques, and other resources to increase cell and body oxygen levels 24/7 and improve health.

Get more oxygen in cells with exercise with nose breathing only

More by this Author

Comments 1 comment

Pharmf231 3 years ago

Hello! fdccdke interesting fdccdke site! I'm really like it! Very, very fdccdke good!

    Sign in or sign up and post using a HubPages Network account.

    0 of 8192 characters used
    Post Comment

    No HTML is allowed in comments, but URLs will be hyperlinked. Comments are not for promoting your articles or other sites.

    Click to Rate This Article