The Unkillable NDM-1 Bacteria Is Spreading Across The World

On the heels of the WHO's announcement that the much hyped H1N1 Swine Flu pandemic was finally over, a new superbug is on the horizon. But this one looks like it really means business.

Britain has just welcomed a new visitor, but it's one that it certainly wishes it could deport right back to its native India: Bacteria that create an enzyme named NDM-1 hitched a ride on "medical tourism" Britons who had visited India and Pakistan for various medical treatments such as cosmetic surgeries which are cheaper on the subcontinent.

In a study published in Lancet Infectious Diseases, researchers point to the unstoppable nature of NDM-1 as it seems to resist any antibiotic in the arsenal, and fear that even though only 50 cases are currently in the UK, it could infect millions of people around the world.

NDM-1 is an enzyme and not a bacterium per se. It can exist inside various current bacteria such as E. coli, and provides them with effective resistance against carbapenems which are the most powerful type of antibiotic substances in the medical pantry.

Researchers believe that NDM-1 is now ready to make the jump to other types of bacteria which are already antibiotic resistant, creating a superbug that would shame MRSA in its ability to survive any pharmacological challenge.

The research has shown that the NDM-1 enzyme containing bacteria have already jumped easily from patient to patient in UK NHS hospitals and the potential for a worldwide endemic is "clear and frightening" according to the study's authors.

Medical conditions on the Indian subcontinent may have contributed to the development of the NDM-1 containing bacteria. Control of pharmaceutical substances is almost non-existent as a great number of prescription drugs and especially antibiotics are readily available if you have the cash but no scrip. The abuse of antibiotics is thus universal as any Indian or Pakistani who feels like they're coming down with a bit of a fever can indulge in antibiotic self-medication to their heart's content.

The study published August 11, 2010 stated that Gram-negative Enterobacteriaceae which already had obtained a resistance to the antibiotic group carbapenem as well as had been "invaded" by the New Delhi metallo-ß-lactamase 1 (NDM-1) enzyme have the potential for becoming a "major global health problem".

In the study, Enterobacteriaceae isolates were sampled from two major metropolitan areas in India: Haryana in the north and Chennai in the south, and these isolates were transported to Britain's national medical reference laboratory. The laboratory identified a total of 44 isolates which contained the NDM-1 enzyme in Chennai, another 26 in Haryana, and a total of 37 in the UK, as well as 73 in a variety of other sites in India and Pakistan. The prevalence of the NDM-1 enzyme was primarily identified among Klebsiella pneumoniae where there were 111 occurrences, and Escherichia coli where there were 36 occurrences. These bacteria with the NDM-1 enzyme were found to be were highly resistant to every single antibiotic tested. There was some effectiveness shown by tigecycline and colistin, but it seemed not enough to call those antibiotics a cure or remedy for NDM-1.

NDM-1 merits close surveillance. Maybe now is the time to invest in companies that produce alcohol hand sanitizer!

Also see: Top 10 Most Frequently Asked Questions About The NDM-1 Superbug Bacteria

Disclaimer: The information on this Hub page does not constitute medical, legal, commercial, product, and/or service advice or endorsement of any vendor, supplier and/or brand, and does not necessarily reflect the opinion of the author. Listing of an entity or service on this Hub page is not a warranty of the quality or efficacy of the products or services furnished by any entity. The author is not directly compensated by any entity other than the advertising placement services shown on this page.

More by this Author


Comments 36 comments

aguasilver profile image

aguasilver 6 years ago from Malaga, Spain

Colloidal Silver, make some, use it, I would calculate it would work for this as well as any other viral carried bacteria or disease.

It costs cents per gallon to make.

Thanks for the info, I'd read about it, but now you've hubbed it, you have saved me a task!


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

I'd be very interested in seeing a study of colloidal silver's effect against NDM-1. Thanks!


sheila b. profile image

sheila b. 6 years ago

Very informative article you wrote here. It's good information to have.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Thanks, I appreciate the kind words! :)


gayle bower 6 years ago

i am a strong believer in collidal silver i hope someone try this on the ndm1 i use it on my family i just saved a 90 year old friend who had a very nasty bladder infection after 5 different antibiotics failed he was very ill but now he is amazing looks younger more fitter and may i say amazingcollidal silver is amazing hope you have news soon


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Since it's quite obvious that the basic arsenal of antibiotics doesn't work against NDM-1, any alternative should be investigated. However, I would like to caution anyone to not use any substance whatsoever until its clinical effectiveness and safety profile has been firmly established and approved by the relevant government agencies for use.


rcguerrero 6 years ago

This is the best written arcticle about this new superbug that I have read. Well said and very informative.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Thank you, I appreciate your kind words! :)


Shalini Kagal profile image

Shalini Kagal 6 years ago from India

As always, a great and informative article, Hal. It's scary how resistant strains are getting and it's sad that it's spreading from India. Is this going to be the next great population controller? It's sure to put our whole burgeoning medical tourism industry in the doldrums!


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Hi Shalini. It seems that the WHO is in the position of playing Chicken Little, running around with the bug of the year calling for pandemic after pandemic. As they still have sufficient H1N1 egg on their face, I think that they're going to be more circumspect and perhaps more realistic this time around. But to stretch the nursery rhyme metaphor, let's hope that they're not the boy who cried wolf and this time around nobody listens to them and it really is a massive killer. I expect the prospect of travelling to your beautiful country to go under the knife to be significantly less attractive today, but maybe the tourists will still want to keep coming over so that they can taste the delectable Sushal. :)


Shalini Kagal profile image

Shalini Kagal 6 years ago from India

I have a strange feeling the prospect of experiencing Sushal will wipe the fear of NDM-1 right out of their minds :)


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Let's see... on this side a big heaping plate of delectable Sushal composed of perfectly al dente arborio rice, kissed with 12 year old balsamic in a "nori" of sauteed spinach leaves and arranged in a church stained window pattern with white asparagus, black truffle shreds, plump sundried tomatoes, tender artichoke hearts, and shredded pressed Parmigiano Reggiano, and on the other side we have an untreatable vicious bacterial infection. I say... damn the bacteria and gimme the Sushal! :)


Shalini Kagal profile image

Shalini Kagal 6 years ago from India

Shhhhhhhhh....shouldn't that be classified stuff????

I agree - the choice is so very clear!


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Oh, that's ok. It's just between you and me and the thousands of people who are reading this Hub today as it made #3 in Google SERP on several keyword combinations within a day of publishing. :)


The Truth 6 years ago

Check out this article and website thoroughly. They are highly informative.

"http://www.physorg.com/news7264.html"

"http://www.silverlungs.com/"

Don't copy the quotes when copying and pasting.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

I repeat: I would like to caution anyone to not use any substance whatsoever until its clinical effectiveness and safety profile has been firmly established and approved by the relevant government agencies for use.


The Truth 6 years ago

Relevant government agencies have a very acute disease which is called Revolving Door Syndrome. It only happens when a big pharmaceutical/chemical companys' CEO quits his/hers position when they are miraculously given the opportunity to take a head position at some relevant government agency. This also happens to coincide when a pharmaceutical/chemical company wants to promote(push through tested or not) a new drug/chemical for human/animal consumption.

Ahh... Corporatism at its best.

Find out how deep the rabbit hole goes at http://naturalnews.com/

http://infowars.com/


aguasilver profile image

aguasilver 6 years ago from Malaga, Spain

As in 'when hell freezes over'?

The antibiotics industry makes BigPharma 3 billion a year, a tidy profit that would disappear if folk all used home made colloidal silver.... The FDA are in BigPharmas pocket 100% so they will NOT be approving CS any time soon, because you cannot patent protect anything that's naturally occurring and in the public domain.

I realise that in the States the FDA have power to stifle free speech and stop anyone telling the truth without a disclaimer, so I know where you are coming from, but CS has demonstrated it's effectiveness millions of times, but not in standard double blind tests costing millions of dollars, as required by the FDA.

Who will comply to those requirements when there is no profit....

The rules should be that the FDA need to PROVE something natural is dangerous, Gods gifts to humanity should be innocent until proven guilty, not the other way around....

Sorry Hal.... off on a rant!


MrHACCP profile image

MrHACCP 6 years ago from Musselburgh

Hal, great hub, voted up. I agree entirely with your views on NDM-1.

I believe NDM-1 will cause problems as the medical profession is still running scared after MRSA and has learned very little as they are too focused on costs and not focused on getting the right staff and training them properly. Until they get their basic hygiene procedures and infection control training right in hospitals across the world we are going to see new emergence after new emergence of this type of issue.

Antibiotics are really very old hat and we need new smart ways to sort these bad bugs out.

I also wrote a couple of hubs on this and it is an issue that will continue until people in the medical profession learn to manage hygiene in conjunction with antibiotics in a way that was natural 40 years ago when there were fewer antibiotics and people by and large lived a healthier lifestyle.

What we need to do is educate people about a) proper hygiene and b) finishing a course of antibiotics so resistance does not occur. If that means refusing further treatment when the patient cannot prove they took them all then so be it.

Only then will we, the so called smarter organism and begin to live in true harmony with nature and the knowledge we have.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

The Truth & aguasilver: I am never going to deny that the whole medical / government / university establishment is riddled with corruption and they all rub each other's backs for grant money and tenure. But the point remains that IMHO there is absolutely no substitute for the conventional peer reviewed process and that any substance, including CS, can be taken into proper clinical tests. Having conducted similar research myself, I can assure you that it doesn't take millions of dollars to do double blinds to current medical research standards. I'm not saying CS is good or bad. All I'm saying is that I belong to the religion of the peer reviewed journal.

MrHACCP: Thanks! It's interesting to note that several leading publications including New Scientist have run editorials today wondering if this is the end of the age of antibiotics. I appreciate your support!


aguasilver profile image

aguasilver 6 years ago from Malaga, Spain

"it doesn't take millions of dollars to do double blinds to current medical research standards"

Glad to hear that, so maybe the government should spend a few bucks testing it to standard and give the world a ruling on it's efficacy?

Thanks Hal.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

I have discovered long ago that you can only depend on the government to pick your pockets. If you want something done and done right and done in an economically feasible manner, do it yourself. I've got the medical background and I have the peer-reviewed publications in my resume. Let's figure out what needs to be done with CS, figure out ways of raising the LIMITED funds that are required to do a good, solid, basic study that can pass review in a prominent journal and let's do it. Yes, it's that easy. No kiddin'. :)


The Truth 6 years ago

Don't steal!

The government hates competition.


The Truth 6 years ago

Big Pharma, who sleeps very comfortably with relevant government agencies like the FDA, WILL suppress anything and anyone that stands in their way of their cash-cow industry of sick care.


aguasilver profile image

aguasilver 6 years ago from Malaga, Spain

Great idea, how much would we need to raise?


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

The Truth, I've been in the medical business for twenty years now, and I've been involved in some borderline major league studies. IMHO if you have hard real proof that can't be nitpicked away, the establishment has no choice but to believe you.

aguasilver, I know nothing about CS. Tell me more and let's figure out what study it would require in order to get into the journals. Only then can we figure out where to put the money and where to save it. I'm up for it if you are.


The Truth 6 years ago

Hal, stick with what you know and educate other people about what you know. Don't attempt to go running around the mulberry bush in vain.


The Truth 6 years ago

Here is a webpage that can give you all the information you need about silver and its amazing properties while present in your body.

Make sure you read the content about colloidal silver that are provided in the hyperlinks.

http://www.silverlungs.com/silver.html


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

My dear The Truth. I have my own criteria about what constitutes The Truth. It's called peer-reviewed scientific and medical journals. The Truth is in there. All of it. If it's not in there, then there are only two other possibilities:

1) It's a LIE.

2) It hasn't been placed into a peer-reviewed journal yet.

Therefore...

I don't believe anything that's on a website. Any website. It's all for entertainment purposes. If someone wants to convince me of something, they show me a legit citation.

Therefore squared...

I'm more than willing to put my money (and time and effort) where my mouth is. I've stated that I'm willing to work with ANYONE to come up with a REAL study on CS that hits all the buttons needed for peer-review. IF that can be accomplished, THEN when I see it in print, I'll believe it. Until then, it's all "cucumber juice cures AIDS" as far as I'm concerned.

So, shall we do this RIGHT, or are you just interested in hawking your unsubstantiated wares to make a buck off my Hub?


The Truth 6 years ago

The information I provided to is necessary if you wish to perform (get cracking on it) double blinds for peer-review analysis. Don't just dismiss the information that is provided before you even look at it.

The truth IS out there.

Plus: CS is not cheap when you purchase it from an all-natural homeopath drug store or a supermarket like Whole Foods. It CAN get rather expensive.

From your experience, twenty years in the medical industry now, I believe that you do know what to do now to get the ball rolling with the information at hand to produce your own limitless supply of CS for inexpensive double blind testing for efficacy, right?

Then after all the inexpensive double blinds are complete, submit them for peer-review. Don't be surprised if your peers shun you and your double blind data.

Here is some information on how silver is used in modern day hospitals.

http://www.nlm.nih.gov/medlineplus/ency/article/00...

http://www.time.com/time/magazine/article/0,9171,8...

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book...


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

I have no intention of doing any study on CS due to my own initiative. Since there seem to be many individuals roaming around the halls of the web trying to hawk this stuff, it would be to their benefit to gain universal scientific recognition of a true peer-reviewed study. It's up to you and your colleagues. Do you want to keep pushing snake oil, or do you want to be on the crest of the wave of a huge new industry? The study holds the key. Don't tell me anything else about any of the real or imagined claims of CS or anything else as I don't care one whit and what I believe or don't believe has absolutely no relevance to the study. You can work with me to put together a consortium that is willing and able to provide the resources necessary (and they aren't THAT much) and I'll spearhead the study. Stop trying to convince me with EXISTING proof because there isn't any. No peer reviewed journal paper = No proof. Period. And that's all there is to that. :)

Now... correct me if I'm wrong, but I've read a medical paper or two in my career, and if you look at your first link carefully, the paper is written to show that silver nitrate eyedrops are DANGEROUS, not therapeutic! Huh? This is like a car salesman selling a sportscar based on video footage of high speed lethal crashes! :)


The Truth 6 years ago

What I just got done telling you is that there WILL be no peer reviewed journal even if you submitted a double blind yourself for review. The buck stops in peer review.

Some more info on silver: How NASA uses Silver.

http://ntrs.nasa.gov/archive/nasa/casi.ntrs.nasa.g...

Interaction of silver nanoparticles with HIV-1

http://www.jnanobiotechnology.com/content/3/1/6


The Truth 6 years ago

I apologize, but my time is limited and must be moving along to the next person who has an ear and is willing to look into this mater for their own personal benefit.

You know... Don't toss pearls before swine.


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

quicksand: Hi, QS! The internet truly is for entertainment only. Anyone seeking hard research has to never venture off a handful of specific .gov and similar sites. Everyone pushes nonsense everywhere. 99% of Hubpages itself is pure unadulterated commercial blather, including a huge number of my own Hubs. :)

The Truth. You are a total fool and a stubborn one at that. There are NO obstacles to the publication of a study, only that it is REAL. But of course, you're too busy googling CS and pitching anything you can grab off the net to support your flimsy hypotheses, even when the papers you grab show that your product is hazardous! Sheesh. My time is limited and I have to engage individuals who have sincere concern for issues, not who are trying to make money by selling crap that clogs up babies' eyes. I take it that the people who are willing to look into this matter for their own personal benefit means suckers who cough up their money to fill your affiliate marketing coffers. Those are not people with ears, they are people without a frontal lobe who are taken for a ride by fast buck artists like you. Take a hike and don't come back to plunk your commercial BUY THIS JUNK NOW affiliate dreck on my Hubs again. And don't let the door hit you on the butt on your way out. :)

Now if there's someone out there who is both serious and has multiple firing brain cells and who is interested in putting together a real study that will get peer-reviewed on CS or anything else, let me know in the comments.


The Truth 6 years ago

Yes Hal you are right, "The internet truly is for entertainment only", as your site proves without a shadow of a doubt.

Goodbye and fare thee well with your endeavors on your entertaining site.

"All the internet is a stage and we are all just surfers."

The Truth


Hal Licino profile image

Hal Licino 6 years ago from Toronto Author

Nope. The internet is a stage and there's way too many snake oil salesmen like you. When the last of your ilk goes broke will be a great day for humanity. :)

    Sign in or sign up and post using a HubPages Network account.

    0 of 8192 characters used
    Post Comment

    No HTML is allowed in comments, but URLs will be hyperlinked. Comments are not for promoting your articles or other sites.


    Click to Rate This Article
    working