The B5 New Acne Cure - Pantethine

Try The New Acne Cure - Experimented For Years

What if you get rid of your acne 2 days from now? No topical applications, no unknown remedies, no toxic drugs, and no overdose supplements. You will just fine tune the supplements you may be already taking.


After the tremendous response to my hub about facial masks, I decided to give you more of my experience as a pharmacist. Today I will present to you the best successful, experimented cure of acne that I have been recommending people for years. It is based on the brilliant basics of biochemistry and supported by recent scientific findings.

The recommended regimen here is aimed at relieving symptoms of acne, it is to be used temporarily and for a short time. Long term use of high doses of these supplements may induce side effects, and some of them may be serious. If you plan to use them for a long period consult your doctor.

12 Years Boys Have No Acne

Children are free from acne until puberty, when all the body activities
are directed towards building more bones and muscles, and preparing the body to reproduce (to preserve life).The pituitary gland (maestro gland) hormones direct the body to serve these purposes, thus :

• Growth hormone increases utilization of fats for energy production, increases lipolysis (fat breakdown by fat cells), spares carbohydrate, and increases protein synthesis.

• Thyroid Stimulating Hormone(TSH) stimulates the thyroid gland to secrete Thyroid hormones, and these increase oxygen utilization and metabolic rate, as well as they increase glucose absorption.

• Follicle Stimulating Hormone (FSH) and Lutenizing Hormone (LH) causes
increased bio-synthesis of sex steroids by the ovaries and testis. Sex hormones build muscles and raises blood glucose so as to be maintained within a certain range.

The net result is increased energy production from fats, decreased energy production from carbohydrates (as it is needed for protein metabolism) , increased protein synthesis, and increased bio-synthesis of sex hormones. The biochemical translation of that is, the production of huge amounts of COENZYME A.

Coenzyme A and Acne

Coenzyme A is the central molecule in our metabolism, it combines acetate that comes from carbohydrates, protein, and fat metabolism to form Acetyl-Coenzyme A, the only molecule that the mitochondria use to produce energy through Krebs cycle. Also fat synthesis - including steroidal hormones - starts with Acetyl Coenzyme A. Acetyl choline the neurotransmitter of all para-sympathetic nervous system can not be synthesized without acetyl-coenzyme A.

Coenzyme A is formed by stepwise union of Cysteine (amino acid), ATP
(high energy molecule), and Pantothenate (Vitamin B5). ATP is provided by metabolism, Cysteine if not present in food can be derived from Methionine (amino acid), and
Vitamin B5 can be only provided by food.

The body deals with the high demand of an essential nutrient in such a way to maintain the functionally more important reactions, while at the same time slowing down the less important ones (or why a certain disease is debilitating?).

In our case, where Coenzyme A is a pivotal molecule in at least 70 metabolic pathways, the body chooses to utilize Coenzyme A and excess fats to build sex hormones, leaving excess fats unprocessed and stored. Were there extra amounts of Coenzyme A, the body would metabolize the excess fat in the sebaceous glands.

Now we can easily understand that acne is due to un-metabolized fat that is accumulated in the sebaceous glands, due to insufficient amounts of Coenzyme A,i.e., acne is due to slow metabolism of excess fat.

Why It Is Hormones Biosynthesis and Not Androgen Effect

The reason acne first erupts at puberty is not effects of hormones, but rather metabolic, it is secondary to deployement of a substantial amount of coenzyme A to the purpose of synthesis of sex hormones. In the following examples we may see that, it is not the androgen that is the cause of acne:

• Eunuchs (early castrated males) rarely exhibit acne, while normal adult males may exhibit adult acne

• Two groups of adolescent boys with the normal blood levels of androgens may exihibit different incidence of acne

• Stress related acne ( prior to examination, tension, insomnia...etc)
is caused by increased synthesis of corticosteroids that the body secretes to combat stress. The same thing apply for adult acne of people who have not had acne as teenagers

• The premenstrual flare of acne patients due to increased levels of progesterone which is not an androgen

• Rapid decline in incidence of acne after puberty is due to cessation of need of increased sex hormones synthesis

• Biotin and Nicotinamide are important vitamins of lipid metabolism, and with vitamin B5 they may help cure acne, yet when they are used alone, they are far less effective in treating acne

• Frequently seen acne with those secreting tumors of the ovary, testis and adrenals, in people with variant ages

Excess Fat

Acne Cure With Coenzyme A

The precursors of coenzyme A are ATP which is very abundant in the body of adolescent people, Cysteine which is non essential amino acid that can be supplied with food or derived from the essential amino acid Methionine, and Vitamin B5 (Pantothenic acid) which is essentially supplied by food.


Pantothenic acid (vitamin B5) supply to increase body production of coenzyme A , has been recommended by Dr Lit-Hung Leung in high doses reaching 1000-1500 times its recommended daily intake which is 10 milligrams per day. The recommended dose is so high (10-15 grams/day), because vitamin B5 is a water soluble vitamin, i.e., with each heart beat the unused B5 molecules pass into the kidney to be excreted. It follows that Vitamin B5 should be present all the time to capture any free Cysteine.

Add Cysteine to Reduce Pantothenic Dose

Since the demand for coenzyme A increases in adolescence, the need for Cysteine must increase. Cysteine is a sulfur amino acid that is heavily used in building keratin, which is an important constituent of the skin (which increases largely in size during adolescence), growing wanted and unwanted hair, and also used in forming nails.

Cysteine free pool in the liver has a narrow range, since the liver cells tightly regulates it to keep it within that range. The liver synthesises Glutathione as a reservoir of cysteine. Glutathione is the primary tool of the liver for detixification. It has a vital role in many cell cycle related events that are needed during tissue repair. It is also vital for maintaining functioning of the immune system.

Cysteine with Glutamic acid (another amino acid) are considered by some researchers to be essential elements for adolescents.

Administration of Cysteine is the only means by which we can reduce the dose of Pantothenic acid. I have recommended the combination of Pantothenic acid + Cysteine for many acne patients for more than 10 years with great results in curing acne.


Taking 0.5-1 grams of Cysteine per day reduces your intake of Pantothenic acid to only 1-1.5 grams per day (they will be combined).

Pantethine, The New Relief

The metabolic pathway of synthesis of coenzyme A involves a compound called Pantetheine which is the direct precursor of coenzyme A. It is now produced in the stable form pantethine, as it involves 2 molecules in the disulfide form of pantethine. It has an extra advantage of being sustained over time, since every molecule has to be split first, and this delays its elimination.

It was intensively researched for its cholesterol and lipid lowering properties (aren't they excess fats?), and has become very popular for cardiovascular support. The literature about Pantethine is full of details about that property, and this made me reluctant to recommend its use for acne, until I found some people are already using Pantethine to cure acne as you can read in the link below.


The dose of Pantethine in most human studies is 900 mg per day and this may be a good guide for us to start with 300 mg three times daily until improvement, it is supposed to improve acne within 2 days.

It is Time To Start

In the below link, there is the details of each product you may choose to cure acne. I included both systems of treatments to overcome the problem of individual variations, so that you may choose the most convenient one that meets your requirements.

If you like take some adjuvants, you may take supplements that contain
Chromium, Zinc, Vitamin E, Vitamin B complex, and Vitamin A, but it is not a must.


More by this Author


Comments or Questions 145 comments

Mat 7 years ago

Does this really work? why we did not hear about it before? is it safe?


elqalatawy profile image

elqalatawy 7 years ago from Egypt Author

Hi Mat,

If you dealt with acne for sometime, you should have heard about use of Pantothenic acid for treating acne, this new treatment is just a modification of the treatment, Pantothenic acid is administered for formation of Pantotheine which is the precursor of Coenzyme A, it is a reduction of one step that costs the body some side effects and some more money, if you find some day Coenzyme A in tablet form take it, this is the final step in the biochemical pathway!

Read about use of Pantethine in message boards of acne.org website, the link is given above.

Yes it is safe, it is recommended to be more safe than pantothenic acid in the currently used doses.


The Break profile image

The Break 7 years ago

Want to exchange links between our two acne hubs?


Mark 7 years ago

First, great blog, i know the b5 works i used it a lot. Now i am very curious if i can do it without the 10 grams i took.

After reading all this, this is my plan.

3 times a day Panthetine 300mg, carnitine 200 mg, b5 500 mg and cysteine 500 mg

So i take all paths.

My question is: When shall i take this with or without meal?

The reason i ask this is that i know that amino acid will compete with each other. But the b5 only worked with me when i took it with a meal. But i want the b5 to catch the cysteine off course.

Excuse my English it is not my language..

Thanks for the great peace of writing in this blog!


Mark 7 years ago

First, great blog, i know the b5 works i used it a lot. Now i am very curious if i can do it without the 10 grams i took.

After reading all this, this is my plan.

3 times a day Panthetine 300mg, carnitine 200 mg, b5 500 mg and cysteine 500 mg

So i take all paths.

My question is: When shall i take this with or without meal?

The reason i ask this is that i know that amino acid will compete with each other. But the b5 only worked with me when i took it with a meal. But i want the b5 to catch the cysteine off course.

Excuse my English it is not my language..

Thanks for the great peace of writing in this blog!


elqalatawy profile image

elqalatawy 7 years ago from Egypt Author

Hi Mark,

Thanks for reading the whole article and you are welcome any time.

The best thing is to take the supplements with meals to avoid any undesired effects on an empty stomach, and don't worry about the competition between amino acids, they are already available in foods we eat.

Good luck!


mzoghori 7 years ago

Instead of using alot of money in trying to cure acne, i would prefer that one tries all the natural methods, that are expense free in avoiding acne. Here are some of the methods that can help you keep off these.

Cloth; You should avoid garments made exclusively of Lycra and nylon if you are prone to body acne since some synthetic fabrics can strap the heat and moisture against your skin. This creates a fertile breeding ground for the bacteria that contribute to acne

For moderate exercise, use light weight, loose fitting cotton or a lycra-cotton blend. Natural fabrics allow the skin to breath and loose garments are less likely to cause friction. If you exercise vigorously and work up a good sweat, try some of the new fabrics designed to wink moisture away from your skin.

Say no to alcohol; if you use a toner avoid products with high concentration of isopropyl alcohol, or common alcohol. A strong astringent alcohol strips the top layer of your skin causing your sebaceous glands to produce more oils resulting to dry red skin and possibly more blemishes.


james smith 6 years ago

Hello

Could u please tell me what would be the most important supplements to take for acne, out of those which you have mentioned.

Many Thanks

John Hooks


james smith 6 years ago

Hello

Could u please tell me what would be the most important supplements to take for acne, out of those which you have mentioned.

Many Thanks

James


CALI 01 6 years ago

I've been taking Jarrow Formulas Pantethine 450mg two times a day for three weeks now. Haven't noticed any significant change to my acne. No cure within two days. Going to finish the bottle since i paid 23 dollars for it.I'm 5'5.5 and 146 pounds. Do you think i should be taking over 1,000mg a day and how much should you suggest is the amount needed to metabolize more fats in order to get a substantial difference in my acne. Is taking 1800mg a day too much?!


elqalatawy profile image

elqalatawy 6 years ago from Egypt Author

Hi CALI 01,

Thanks for visiting!

I think if you take one more capsule of a supplement is not too hazardous, try combining with your best treatment you've noticed an improvement with it before.

I wish you the best of luck.


TS 5 years ago

For a majority of people Pantethine works better than PA. Pantethine is the biologically active form of PA and has been seen to offer more benefits than PA.

Good info!


Dan 5 years ago

Hi do you have to take anything with pantethine for it to work like cysteine or b complex? And can a small dose be jus as effective to someone who gets regular few spots not full on acne? Overall is it more effective then PA as it seems easier as its less pills


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi Dan,

Thanks for visiting!

Cysteine is needed to form pantethine, so there is no need to take it however if you like to take some B complex, it is OK.


Dan 5 years ago

What do you thinks better to take as ive bought both incase one dont work i can try the other pantothine sounds easier but dont no how effective they both are compared to each other


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Start with Pantethine and see.


Lee 5 years ago

Do they have to be taken after/ with food or does this not make a difference?


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

After meals.


Tom 5 years ago

Firstly great article thanks for compiling it.

I have been reading about the internet and there seems to be quite a few cases where people achieve better results using pantothenic acid in 10g doses as appose to taking approximatley 750mg of pantethine three times a day.

I have moderate acne and have never tried this type of treatment before, i want to give this treatment a go; so which should I start with pantethine or pantothenic acid???


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi Tom,

Thanks for visiting !

The purpose of use of Pantothenic acid is to synthesize Pantethine, isn't it much easier to use pantethine? by using it you can reduce the huge dose of pantothenic which has some impacts on the tissues.


Mihai 5 years ago

Hello Mr elqalatawy,

Thank you for this information!

I would like to ask you a question regarding methionine: You said that cysteine is derived from methionine, so if one would like to take methionine instead of cysteine, what quantity of methionine will be required in order to produce the recommended 1-1.5 grams of cysteine daily?

Thank you in advance!


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi Mihai,

Thanks for the visit.

As you see the whole idea is to increase the existence of a certain nutrient, no calculated values, so you may take Methionine in its recommended dose as a supplement, I think 1 g daily is sufficient.


Mike 5 years ago

L-cysteine or N-Acetyl-Cysteine? Thank you


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi Mike,

Thanks for stopping by.

it is L-Cysteine.


Mike 5 years ago

Why is not better N-Acetyl-Cysteine than L-Cysteine? N-Acetyl-Cysteine (NAC) has all the properties of L-Cysteine but is more water soluble and said to be more bio-available than L-Cysteine.


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

The enzyme that is involved in the reaction catalyzes the reaction between Pantothenate and L-cysteine, it can not act on N-Acetyl-Cysteine because it has specific sites for the reactants, like the lock having a specific key.


joao 5 years ago

diga adeus ao acne


John 5 years ago

I have read on various websites that Coenzyme A is synthesized within the body by three precursor chemicals (pantothenic acid, cysteine, and ATP -Adenosine-5'-triphosphate). Even if we take pantethine instead of pantothenic acid, why would we not also want to supplement with cysteine?


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi John,

Thanks for the comment.

Pantothenic acid reacts with cysteine to produce pantethine

which further form coenzyme A, thus when we use pantethine we reduce the reactions by one step.


acne treatment review 5 years ago

Marvellous job for the valuable information.


Mihai 5 years ago

Hi elqalatawy,

I used your advice and I'm taking 500mg L-Methionine and 500mg B5 two times a day. It does reduce sebum and acne, although I don't have a lot of acne anymore (I had it bad when I was younger). I just wanted to report that it works and to thank you again for your site!


John 5 years ago

Pantothenic acid and hairloss.

If you search the net, there are a lot of people complaining of hairloss when taking large doses of pantothenic acid. There are quite a few theories:

1) Pantothenic acid lowers Biotin causing hairloss

2) Pantothenic acid lowers cysteine causing hairloss

3) Pantothenic acid raises DHT levels causing hairloss

4) Pantothenic acid decreases pore size causing hairloss

There are enough people reporting it, that it has me concerned. Please comment on the following:

1) Why does Pantothenic acid especially in large doses cause hairloss?

2) What can be done to prevent pantothenic acid from causing hairloss?

Thank you!


ken 5 years ago

will there be any rebound reaction after stopping pantethine? thanks


ken 5 years ago

hello, may i know will there be or any reported case of rebound effect after stoppig pantethine?


elqalatawy profile image

elqalatawy 5 years ago from Egypt Author

Hi Ken,

There are no rebound effect after stopping pantethine per se, yet you should be acquainted to the fact that whenever there is a factor that slows down fat metabolism and causes accumulation of sebum, you will experience acne and you will need to take pantethine again.

Good luck.


harry 4 years ago

is it more effective to take pantethine or is it more effective to take pantothenic acid and cysteine?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Harry,

I have tried cysteine and pantothenic acid, it is supposed that the body will utilize them to form pantethine. Theoretically, pantethine is better yet I did not try it.


jon 4 years ago

with pantethine, can you take 2 300mg pills in the morning and one at night or does it have to be spread out throughout the day?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi jon,

It is a supplement that can be taken any way and you have to try.


sam 4 years ago

what do you think about combining pantothenic acid with pantethine? I have read several places that it is most effective this way!


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi sam,

Just try them.


Earl 4 years ago

I tried pantethine for 1.5-2 months. I can't say that it made that much of a difference in my skin or in my oil production. Should I increase the pantethine? How much can I safely take?

Thank you!


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Earl,

Keep on the dose but you may add L-Methionine 1 gram/day.


Earl 4 years ago

Thank you for the response back. I am currently taking 900 mg of the pantethine in three divided doses. I am willing to give the Methionine a try. However, I thought that if you are taking patethine you do not need Cysteine or Methionine. Please explain.

Thank you!


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Theoretically you do not need these amino acids with Pantethine, however practically there would be a biochemical distraction away from that pathway, so we need to support this same pathway. It is the same idea that made Pantothenic to be advised in 1000 times its recommended daily intake.


Earl 4 years ago

In addition to taking the Methionine. I was thinking about adding L-Carnitine. Supposedly it helps transport fatty acids across the mitochondrial membrane where they can be oxidized. In theory it reduces the amount of b-5 you have to take. For more information see - http://jeffreydach.com/2008/09/04/pantethenic-acid...

What do you think?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Earl,

Yes it is right, we just try not to reduce expenses. Methionine will reduce the dose of VITAMIN B5.


Earl 4 years ago

Thanks again for the response. OK I am trying the Methionine (1,000mg) + Pantethine (900mg). To get the maximum oil/sebum reduction, do you think I should add some L-Carnitine? If so, how much?

Thanks for all your help!


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Earl,

You are welcome any time.

There is no need for L-Carnitine, but if you would like to explore take it in its recommended dose.


Earl 4 years ago

From what I understand Pantethine turns into Coenzyme A. Coenzyme A is responsible for oxidizing or burning up fatty acids which in turn reduce oil or sebum on the skin. L-Carnitine is a transporter of fatty acids. It transports fatty acids to be burned up as energy. As an analogy. Coenzyme A is the furnace that burns up fatty acids. Carnitine is the delivery truck that brings fatty acids to the furnace.

Doesn't it make sense to take both of them?

Thanks!


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Earl,

You are right except that Coenzyme A is the tray that introduces the splits of fatty acids into the furnace one by one.

The question is why do we make all these efforts to erase fatty bumps? they will show again frequently!

My point is that we keep acne at bay with the least efforts and costs, whenever it comes.

If you want to try it go ahead and try, it's your money.


hector 4 years ago

Your article says to take the pills (Pantothenic acid and Cysteine)temporarily and for a short time. How long would you recommend taking them for then. I was thinking 2 weeks on one week off.

Thanks


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

You use them until acne is gone. If you don't get good result you may shift to using Pantethine http://hubpages.com/health/Acne-Cure-Guarantee...


David 4 years ago

Hi,

thank you very much for your enlightening posting. As in my country Europe Pantethine is not sold as medicine, I only use Pantothenic Acid and L-Cysteine. My skin is getting better with 1,5g PA and 1g L-Cysteine. As I use this regimen for less than a month, I wonder whether it will be getting better even without Pantethine.

Thank you for your reply.

Yours sincerely,

David


Maj 4 years ago

Hi,

I have been reading up on pantothenic acid and pantothine. I will be starting one of them but have been getting mixed reviews. I read that Pantothenic acid and Pantothine have different effectts. Im just abit confused on which one would be best to consume? Is there any difference between them??

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Maj,

Pantothenic acid is a precursor of Pantetheine. Pantethine contains 2 molecules of this Pantetheine linked together.

You better start with Pantethine as it will save you taking Cysteine, and it has good results as well.


Maj 4 years ago

Hi,

Thank you for your response. I have purchased jarrow formulas pantethine 450mg. Do I stick to the normal dosage of 900mg a day for acne? I have tryed everything and very frustrated at this moment as nothing is working. Also I take actyl L carnitine on the days I go gym as it is also meant boost your energy levels and use up the stored fat (I hope this is correct). But have been noticing more spots than usual, does this mean that I should stop taking this? Or is this just an initial breakout as I also heard it helps with acne.

Thank you for your time, I look forward from hearing from you.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

In this hub you will read the experience of jhwilso1 and how he got the same effect you describe, so he quit L-Carnitne, you will also read about different dosage regimens he had used:

http://hubpages.com/health/Acne-Cure-Guarantee...


Maj 4 years ago

Hi,

Looks like hr had good results only he was not taking pantethine but patothenic acid with cycsteine, Has anybody ever had improvements with pantethine instead of using pantothenic acid?

Regards,

Maj


Maj 4 years ago

Hi elqalatawy,

I was reading up on pantethine as discovered a post;

'pantothene is used for different purposes than pantothenic acid. it's main use seems to be for helping the body burn energy quicker thus lowering the level of cholesterol in the body. So it is mainly used by people with high choleterol. Pantothenic acid does nothing to the bodies cholesterol levels so cannot be used for this purpose. Also pantothene has shown no signs of lowering sebacous gland production in the body. So no pantothene is really no use for acne or oily skin problems.'

I have just purchased pantethine and after reading this and other posts regarding pantethine it has made me begin to think maybe i should use pantothenic acid instead??? Please could you elaborate on this matter for me?

I look forward to hearing from you.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Maj,

Use Pantethine, it is now tried by many individuals.


Maj 4 years ago

Hi,

Really sorry for annoying you again I just have few more questions.

I am on my third day of taking pantethine and I am taking 450mg twice a day.

Is it recommended to take more than 900mg of Pantethine?? or should I stick to 900mg?

Also I have ordered Pantothenic Acid which I am planing to take 500mg once a day inbetween my Pantethine doses. Would this be ok??

How long does it take to see results??

Thank you for your time.

Kind Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Maj,

There are different dosage regimens of Pantethine and Pantothenic acid that can relieve acne, here is the experience of jhwilso1 of usinf them:

http://hubpages.com/health/Acne-Cure-Guarantee...

You wil find it in comments.


Maj 4 years ago

Hi,

I have been reading 'jhwilso1' posts and it seemed that PA and Cystien worked better for him. But after reading so much of the post all the questions have confused me as I am completely new to all of these vitamins.

I hope you can shed some light here.

I am currently taking 450mg of Pantethine twice a day and I am thinking of taking an extra which makes it 3 x 450.

After only 3 days my skin feels tight and dry im not too sure if this is the Pantethine working. Skin seems to look somewhat clearer but still have a few spots on my forehead and cheeks.

I have ordered vit b5 which I plan to take 1 x 500mg a day, Will I need b Complex vitamins??

You said that ATP is present in people upto the age 20 (i think) I am 24 so does this mean I need to supplement with ATP? What about Cystien? If my body has not produced enough Cystien does this also mean Pantethine will not be effective?

I look forward from hearing from you.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi Maj,

jhwilso1 said that he takes Pantethine 450 mg 5 times a day, yet this exceeds the recommended dose which is 1200 mg per day.

ATP is available inside all ages, and what I can say to you is that what you describe is promising, either you proceed as you do now for some more time, or you take PA with Pantethine.


Maj 4 years ago

I would really like to thank you for being very helpful.

I really hope this works for my self as well as anybody else who is trying this.

Regards,

Maj


Maj 4 years ago

Hi,

I have a concern on pantethine.. I have been taking 450mg 3 times a day... On day 4 my skin now looks worse as im geting spots everywhere on my face.

Should I stop the regimen? My body may not be reacting to this treatment as it should be. Or is this normal? My skin looks much worse than it has previously.

I await your response.

Regards,

Maj


Maj 4 years ago

Hi,

I have a concern on pantethine.. I have been taking 450mg 3 times a day... On day 4 my skin now looks worse as im getting spots everywhere on my face.

Should I stop the regimen? My body may not be reacting to this treatment as it should be. Or is this normal? My skin looks much worse than it has previously.

I await your response.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Would you ad Pantothenic acid?


Maj 4 years ago

Hi,

I am currently waiting for my PA to arrive in post... Does this regimen cause an initial breakout?? Or am i getting spots because this is not working for me?

If i add PA how much dosage?

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Yes, you may get some breakouts at first. Take PA 1-2 grams per day.


Maj 4 years ago

Hi,

I received my PA today, just a few questions.

Morning I take 1 450mg pantethine With breakfast, with lunch and then 1 in evening. Inbetween the doses can I take 2 500mg PA? In total 2gm of PA. Will this cause any side effects? Do I need bcomplex?

Or should I start off with taking 1gram then pick up to 2??

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

If you want to start with 1 gram then pick up to 2 with pantethine, it is OK. You do not need any other supplement.


Maj 4 years ago

Sorry just abit of confusion..

I am taking pantethenic acid which says its from calcium pantothenate.. Is that ok?

Also can i stick to 3 x 450mg of pantethine a day? Or should i reduce this to 2 a day and take 2 grams of PA?

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Calcium Pantothenate is the pharmaceutical form of Pantothenic acid. it is OK.

As for the dosages you may need to try them starting with the recommended doses. Start with 2 capsules of Pantethine and 2 grams of PA.


Maj 4 years ago

Hi,

If it takes 10g of PA to cure acne why is it recommended to take 900mg of pantethine? And not 10g?

What is 900mg equivalent to PA? And why such a less dose? Although PA breaks down into Pantethine would it not make sence to keep the dose at the same level as it is only a less step in the pathway but not less in dose??

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

It is the enzyme activity in each individual that makes us try to manipulate the B5 intake.

The recommended dose of B5 is 10 mg/day, anything beyond this dose is a studiousness and we should be careful not to flood the system, with high doses of anything however it is safe.

jhwilso1 had increased the dose of pantethine to 450x5 times and he got a clear skin, yet I do not recommend that for very long.


Maj 4 years ago

Hi,

Another question sorry.

How long do I need to stay on the following dose;

2 x 450mg Pantethine

2g of PA

I haven't seen any improvements yet. I have added b5 and it has only been 4 days but it has been 10 days since I have been on PA but my spots dont seem to be getting any less. ( i have mild acne).

Am I the unlucky one who this does not work for. I guess accutane may be my only hope but I really really do not want to take that.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Add Panthenol cream.


Maj 4 years ago

How long do i need to be on this dose or should i increase?

What is panthenol cream?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Panthenol is the alcohol form of PA, it is converted to PA after being absorbed from the skin. This makes you not needing to increase the dose.


Darragh Herbert 4 years ago

Hello i have been reading your threads and am very impressed with your findings well done! I have used PA(B5) on its own before with great success but the second time i used it it did not work(Maybe the pills were poor quality) anyway my question is do you think i should start with the pantethine (900mg) daily or else the 'Co-enzyme A' tabs. I know the co enzyme A tablets have pantethine in them at 1000mg and a host of other ingredients. Not sure where to start? any feedback be great thank you very much


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Go Pantethine.


Darragh Herbert 4 years ago

Thank You i'll let u know how i get on


Maj 4 years ago

Hi,

I have seen a slight improvement since the last time I posted on here but I am still not getting the desired results as I still have spots.

I am currently taking 2 x 450mg Pantethine

3g PA.

I started off with 2 grams of PA now upto 3. I was wondering can I Increase this dosage upto 4g of PA? As I feel that maybe my body needs more PA and that is why my spots are not clearing.

Thanks

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Add 1 capsule of Pantethine.


Maj 4 years ago

Hi,

I have had taken your adivce and started taking one extra capsule of Pantethine. In total I was taking 3 x 450 split through out the day and I was also taking 3g Of Panthenic Acid.

I have seen no difference at all. If I was to lower the dose of Pantethine to 2 x 450 and up the dose of Pantenthenic Acid to 5g split in between my day. So 1 Pantenthine in morning then at lunch 2.5g of PA, then for Dinner 2.5g of PA and before I go to bed 1 capsule of Pantethine.

Will this dose be harmful to my body?? Will I need to take b complex?? or should I just give up on b5? Id say it has been a little over 2 weeks.

Regards,

Maj


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Maj,

Give up PA and use Panthenol cream with pantethine.


Maj 4 years ago

Where do i get this cream from?


Maj 4 years ago

I can only find d panthenol cream or b3 panthenol cream are they the same?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Yes, it is D-Panthenol. You can get it from Amazon, there is a cream called Penaten which is 5% dexa panthenol, this is the best concentration.


Darragh 4 years ago

Hi ive been doing the Panthetine(900mg) for over a week now and my skin has cleared up 99% but strangely my skin is still real oily(even could be oilier)so its like the oil coming out is clean.. Should i add more Pathethine or just give it more time to work? Thank you


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Darragh,

Use D-Panthenol cream.


Darragh 4 years ago

Hi is it the baby cream Penaten? http://www.amazon.com/Penaten-Cream-Cr%C3%A8me-Lar...

I'm sorry but i know creams are not going to stop my oily skin it needs to be healed from the inside


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

yes it is this cream. This cream will heal you from inside the sebaceous gland itself, just try it.


nouha 4 years ago

would it be ok to take coenzyme A with this penaten cream?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Hi nouha,

There is no problem, both increase the concentration of coenzyme A in the skin, nevertheless you need to adjust the dose, you need them just to clear acne and anything beyond that is not required.

I mean you keep the skin neither oily nor dry, just tell me.


Darragh 4 years ago

Hi Elqalataway,

I have just received the Penaten cream, Do i apply it all over my face or just on oily parts of my face or on acne prone parts of my face, Thank you for your help hope this works to reduce oil and sorry do i use morning and night or just night time? Thanks again


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Use it freely on the acne prone parts of your face, use it morning and night. I will be waiting for your feedback. I wish you good luck.


Darragh 4 years ago

Thank you i will give it a week or two and let u know how i get on thank you for the quick responses means alot


:D 4 years ago

Hi. I can't find this Penaten cream in my country but i have an alternative. It is called Bepanthen (it contains 5% dexpantenol). What do you think? Is it a good replacement for Penaten cream?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Yes, it is very good.


:D 4 years ago

Thanks for your answer. I already bought this cream. It contains: aqua, panthenol 5%, isopropyl myristate, cetyl alcohol, stearyl alcohol, propylene glycol, lanolin, potassium cetyl phosphate, pantolacton, phenoxyethanol, potassium hydroxide. I read the intructions and it says that this cream is greasy, suitable for dry skin. I'm in a dilemma because I have oily skin and this combination (my face + bepanthen) can have comedogenic effect. Any advice please?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Mix it with some glycerin.


:D 4 years ago

Thanks. One last question. I understand this kind of cream prevents acne but is it effective on active spots? Also is it active on blackheads, whiteheads?


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Yes, it helps clear fat in active spots, blackheads and whiteheads.


Darragh 4 years ago

Just to let you know 4 Panthitne a day(1800mg) is not working still getting spots and oily skin. Moving to six(2700mg)for a few weeks then giving up if no difference


:D 4 years ago

Darragh but what about the cream? Did you get any results?


Darragh 4 years ago

The cream is way too thick to use i tryed it one night and does not properly absorb into the skin, it is not made for the face, I could use it at night but not a chance in the morning way to thick.. I believe myself creams are not the answer, I dont see how a cream can stop your skin from producing oil, I started 6 tabs(450mg) yesterday i'll give it a few weeks but im optimistic, dryer lips is all i can feel at the moment. Are u using the cream any results?


:D 4 years ago

I'm using Bepanthen and I saw this cream has other ingredients than Penaten (beside 5% dexpanthenol). But it is also a geasy cream. Until now I used it only for my back in combination with Brevoxyl (4% bpo). I'm applying Brevoxyl to kill p.acnes and after 20-30 minutes I'm applying Bepanthen. After 5 days I can say I really see a difference. I'm not seeing new zits forming but i have many marks from previous ones (i'm having bacne for years now). It;s a good result for only 5 days of treatment and I will continue at least 1-2 months with it.


:D 4 years ago

Mr. Elqalatawy what is your oppinion about niacinamide (niacin, B3 vitamin) cream in treating acne?


Michael 4 years ago

Thank you very much elqalatawy for this hub-page and following up with your comment.

I started out taking

Two - Vitacost L-Cysteine -- 500 mg

Two - Twinlab Pantothenic Acid B-5 Caps -- 500 mg

One - Kal Pantothenic Acid -- 1000 mg

One - Twinlab Niacin B-3 Caps -- 500 mg

During this time, my acne has already comeback in full force from not taking doxy anymore. After a week on taking these vitamin, my face got worse and hurt so bad from the itches or moving my mouth or forehead skin. Thank goodness college just ended so I spent my whole week in bed trying to sleep off the pain. I was about to gave up and go get some doxy without insurance(doctor visit co-pay), but keep coming back to this hub-page, seeing how the author continue to post comment, I decided to stick to this.

I decided to add one more Kal Pantothenic Acid -- 1000 mg to my daily intake. Two week now, my painful acne started fading, but some new one are forming by the ear and under my chin, but a few day later, it doesn't hurt as much anymore.

Anyway, I still have some bump left and red mark, BUT, I can now eat and talk without my acne hurting, or move my forehead skin. RELIEF

I am starting to think this is working and hopefully won't jink it. I will update next time when my acne bump clear atleast 90%(hopefully stop taking b3 by this time) and another update when my red skin mark turn back to normal.

Anyway, vitacost is having a promotion of B1G1 50% off for Vitacost L-Cysteine, plus you could get $10 for new user, or sign up through this link so we both could get $10. That mean you could get about 6 month supply for less than $10 a month.

http://www.vitacost.com/Referee?wlsrc=rsReferral&R...

[$14.99] - Vitacost L-Cysteine -- 500 mg - 180 Capsules

[$7.49] - Vitacost L-Cysteine -- 500 mg - 180 Capsules

[$4.56] - Twinlab Niacin B-3 Caps -- 500 mg - 100 Capsules

[$11.83] - Twinlab Pantothenic Acid B-5 Caps -- 500 mg - 200 Capsules

[$14.84]- Kal Pantothenic Acid -- 1000 mg - 100 Tablets

[$14.84]- Kal Pantothenic Acid -- 1000 mg - 100 Tablets

Total = $68.55 - $10 = $58.55 (No tax for me plus free shipping CA, USA)

So new routine for me is:

Vitacost L-Cysteine - 9:00 a.m. & 9:00 p.m.

Twinlab B-5 - 10:00 a.m. & 9:00 p.m.

Kal B-5 - 1 p.m. & 12 p.m.

Twinlab - 12:30 a.m. or right before bedtime.


elqalatawy profile image

elqalatawy 4 years ago from Egypt Author

Try stopping B3.


Jo 4 years ago

Ive taken pantothenic acid many times on and of n all i have to say is it doesn't take more than 4 days for your acne to completely disapear,,, TRUST ME, panthenol has mixed reviews meaning it doesn't work nor have any connection with pantothenic acid, they just want you to buy their crap,, stick with panto. Acid i been using it for a while, proactive clearasil All crap compared to this


Michael 3 years ago

Glad I didn't give up as I can say I'm 90% clear now.

I up my doses to 2 gram L-cysteine, 6 gram B-5, and 900 mg Jarrow Pantethine a day. For the first 2 month, my crystal acne disappear but kept appearing in another spot, I was going to give up but was going to keep taking all the pill until I ran out. The 3rd month, I started getting vulgaris acne since my skin became more dry, but no more crystal acne, my skin still has lots of old red acne mark that looks like there are still acne there. Month 4-5 my acne starts fading away and the red mark on my forehead and cheek started fading but by neck and around my jaw was still red. I was running low on the pill, so I decided to stock up for another 2 month. Month 6-7, the red mark are clearing up and when I get a pimple, it usually disappear completely in 1-2 days.

SOOOOOOOOOOOOO Happy! Thank you sir, you save my life, now I can concentrate on finishing my degree and move on to a brighter future. Also, my lip are getting dry, don't know if its the heater or not, but I'm going to start lowing my dosage now, think I will lower b-5 to 4 gram first.


mikey69 3 years ago

I been using b5 and L- cystein for 4 months! I take 5 500 mg of b5 a day along with 500 mg of L-cystein 3 times a day! Everything was working well up 2 the past to weeks! my face exploded in oil again, I try to stick it out but its so oily please help!


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Try detoxifying your liver (Milk Thistle, Dandelion...etc).


Mike 3 years ago

Hi.I was contemplating my 4th course of Roaccutane before reading this hub.

I'm a 33 year old man. About to start on this. Just a little confused by the discussion sbove (as a non-scientist). Planning each day, initially, to take:

-3 x 1gram of PA; with

-3 x 250mg of cysteine.

Do I need to take a b-complex and/or panthenine? Will the above dosage levels be too low to bring about results? Is the above a good starting point?

Many thanks.

Mike

Yorkshire, England


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Hi Mike,

Yes it is a good start. You may not need to take any supplements.


Mike 3 years ago

Thanks. Acne has blighted my life for 20 years so I'm optimistic about this!

One quick question: is it better to take PA and L-Cysteine in tablet or powder form?

Many thanks.


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

You take the form that are comfortable with, they are nearly the same.


Mike 3 years ago

Hi. I decided to take (each day, evenly spread):

- 6 grams of Pantothenic Acid; and

-1.5 grams of L-Csyteine.

Been about 2 weeks on this regime. Getting (still) 1 new spot each day. My spots take a very long time to fade (despite trying to maintain a good diet and drink lots of water). I am very impatient as I've been fighting acne for about 20 years. I am anxious that my acne isn't responding as I'd hoped.

My questions are: do you think my balance between PA and Cysteine is about right (6 g :1.5 g)? Would you recommend my using Penaten on existing spots and/or adding Pantetheine tablets? (Is Penaten just to be used on existing spots or should it be applied each morning and evening as a matter of course to prevent lesions appearing?)

Like everyone on here, your expertise and help is really valued. Many thanks.


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Hi Mike,

Use Penaten cream with Pantethine tablets.


Kiat 3 years ago

Hello elqalatawy,

Thank you for the article. I like it.

What do you recommend between B5 and Pantethine for someone who never try any of these?

I was on Accutane for 4 courses, all on low does. Been 1.5 years now and acne is bounching back. I am using topical Paula's Choice CLEAR program and it's working. However, new pimple occurs every day, about 1-2, although small I am unhappy with red marks it left behind.

Because of new pimple every day, I want to reduce oil production. Actually I can go back on Accutane but its toxicity is much unwanted.

FYI - I also lose about 40-60 hair / day.

Well, these are supplements I'm taking, can you recommend what to take out and what to add?

Country's Life - Buffered C 1000mg

Swansons Hair, Skin & Nails

NOW Foods L-OptiZinc

Swansons AjiPure N-Acetyl-L-Cysteine

Swansons Grapeseed

Doctor's Best Astaxantin

Swansons Saw Palmetto extract 160 mg

Swansons Resveratrol

Swansons Royal Jelly

Swansons Betacarotene 25,000 IU

Swansons Vit E (dry) 400 IU

Carolson Salmon Oil

Country Life Natural Vitamin D3 400 IU

Carlson Selenium

JARROW CURCUMIN

Swansons Dr. Stephen Langer's Ultimate 15 Strain Probiotic with FOS

-----------------------

Thanks elqalatawy :-)


Mike 3 years ago

Hello everyone

A quick update: I have had a very good 2/3 weeks since I increased my dosage levels to 7 grams of PA with 1.5 grams of L-Cysteine. I get the occasional spot but it's 100% better. I plan to keep it at these (high?) levels for 2 months and then try to reduce, slowly, the amount of PA I take. My acne is cyclical so a cynic might say that this currently excellent period is just my body in a good part of its cycle. I do however think that this regime work is working for me. Thanks again to Elqalatawy.

Mike, England


Mike 3 years ago

Just a quick update: this regime has definitely cleared my skin. Very pleased. To those who are undecided about trying it, I would say 100% give it a go. It works. (7 grams of PA and 1.5 grams of L-Cysteine).

I've got 4 weeks before I start to reduce the amount of PA I take. Bit nervous about this in case the acne returns. But, for the moment, it feels incredible to have skin that is 100% clear (even with a diet that includes caffeine and dairy).

Mike, England


David 3 years ago

Hi elqalatawy,

Vitamin B5 in large quantities is known to cause hair loss. I have the same question that another person (John from about 2 years ago) does:

1) How can we avoid the unpleasant side effect of hair loss?

2) What dose of B5 is safe (and effective) to avoid hair loss?? and

3) What mechanism causes B5 induced hair loss???

Thanks much!!!


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Hi David,

1- You can avoid hair loss by reducing the dose of vitamin B5

2- The optimal dose of vitamin B5 is 1-2 grams/day

3- The mechanism of hair loss is unknown but it may be induced by reduction of the amounts of l-Cysteine in the blood (to form Coenzyme A), l-Cysteine is needed for building keratin which the main constituent of hair.


David 3 years ago

Thanks for your prompt response elqalatawy,

I am already taking L-Cysteine with B5 (and biotin) for 8 days now with only minimal results. I started at 10 grams of B5, but soon lowered the does after finding many people online complaining of hair loss symptoms even after stopping the B5 for many years. Since I am not seeing any real significant improvement in my oily skin / relentless cystic acne problem, what specific dose of L-Cysteine to B5 do you recommend????

I am currently taking 2 grams of B5 (3x/day) with 1 gram of L-Cysteine (also 3x/day) for a total daily dose of 6 grams of B5 and 3 grams of L-Cysteine, but I would love to hear your suggestion. Thanks again, you have been very informative.


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Hi David,

You welcome.

Keep on this regimen but you may try a liver detox.


David 3 years ago

Hi elqalataway and thanks for your response,

Already on that, been doing liver flushes for about a year now. I hope to run out of stones soon. Also already using milk thistle.

Update: It's now day 10 and I am starting to get less oil, so it seems to be starting to work. My (hopefully) last questions are: 1) How long is it safe to stay at this B5 dose (6 grams B5 with 3 grams L-Cysteine daily)? and 2) What dose should I drop down to to maintain (for the rest of my life I suspect)?? 3) What is the highest SAFE maintenance dose???

Thanks so much!!!


David 3 years ago

Hi elqalataway again,

I'm just curious now. How is it that a toxic liver causes an increase in oil production (leading to acne)?

Thanks!


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

For maintenance you may keep using these supplements whenever acne shows up, I can not recommend that you take anything for life.

As for the liver detox, it is hoped that it may help the liver to maintain L-Cysteine pool in the healthy range. L-Cysteine is an example of a tightly controlled amino acid that is widely used in structural biochemical reactions, like formation of hair, nails, hormones, enzymes ...etc., this pool is regulated by the liver.


David 3 years ago

Thanks elqalataway,

But please let me get this strait. You are saying that B5 in high doses lowers L-Cysteine, and low L-Cysteine is responsible for hair loss and oily skin or just hair loss? I am also trying to figure out the connection between liver function and oily skin. My best guess is that a poorly functioning liver is not filtering out all of the used/broken down sex hormones and it's the extra sex hormones floating around that are responsible for the oily skin (among other things). Am I on track here?

Also, there are some who are claiming that B5 also depletes copper (in addition to L-Cysteine) and that copper depletion could be partially responsible for B5 relate hair loss. Of course if you supplement copper, you also have to supplement Zinc because they basically compete. I would love to hear your thoughts on all of this because I honestly don't know what to make of it.

Thanks again!!!!!


elqalatawy profile image

elqalatawy 3 years ago from Egypt Author

Hi David,

Unfortunately I can't comment on the scientific speculations or proposals you have displayed because they need experimental work, when I added L-Cysteine to Pantothenic acid was just to increase the amounts of Coenzme-A and it worked.


Daivd 3 years ago

Okay, thanks for the info!


David 2 years ago

Hi elqalataway,

New info: Just found that there are a number of guys who are experiencing hair loss despite using L-cysteine with B5 (in a 2 to 1 ration of b5 to L- cysteine). Would love to hear your take on this. Thanks!


elqalatawy profile image

elqalatawy 2 years ago from Egypt Author

Hi David,

Hair loss with what doses.


David 2 years ago

Hi elqalataway,

I looked into it and from the threads, it's really difficult to tell because the guys use was so inconsistent with their doses. But they were using a 2:1 ratio of B5 to L-Cysteine. I guess the important question is: What is the highest "SAFE" does of B5 when taking it with L-cysteine?

Also, do you think that the addition of L-carnitine might make the B5 even more effective, thus allowing a lower effective B5 dose?

A BIG THANKS as always!


elqalatawy profile image

elqalatawy 2 years ago from Egypt Author

Hi David,

Usually the supplements are taken in the range if 1-2 g/day but since b5 was taken in high doses reaching 10g/day, it is difficult to discriminate the optimal dose.

As for L-Carnitine I don't recommend it since it caused aberrations of treatment in some cases.


nar 2 years ago

Hello. I was using Pantothenic acid with L-cysteine, and my acne was gone. now I am using Pantethine and I see that my acne starts to appear again, should I stop taking Pantethine and stick with the Pantothenic acid and L-cysteine?


elqalatawy profile image

elqalatawy 2 years ago from Egypt Author

yes because there are individual variations in response.


Joe 2 years ago

Hi,

In your article here you mentioned the following:-

"The recommended regimen here is aimed at relieving symptoms of acne, it is to be used temporarily and for a short time. Long term use of high doses of these supplements may induce side effects, and some of them may be serious. If you plan to use them for a long period consult your doctor."

With this I have some questions:-

1) How long is the temporary or short time?

2) What side effects it may cause for long term uses?

Thanks for enlightening.


elqalatawy profile image

elqalatawy 2 years ago from Egypt Author

Hi Joe,

1 month is a sufficient time to improve the case and being safe at the same time.

For side effects which accompanied use of high doses of Pantothenic acid (10 grams/day), they were hair loss, some mood changes ...etc and you may find the exact details in some forums, just type in "side effects of high doses of pantothenic acid"


Dave2409 21 months ago

Hi guys I did the while vitamin b5 thing about 4 years ago it cleared my acne fast but I've lost about 60-70% of my hair and I'm still shedding now, I don't know what to do, I tried l-cysteine a while ago but no luck. Please help

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