I have never heard of either glucosamine or chondroitin causing even mild increases in cholesterol. These products are as you may know, utilized to promote overall bone strength. But please do not quote me on that. What I can tell you however, is that Vegetable oils, which are free radicals, are one of the major contributors to cholesterol that builds up in the muscle walls of our arteries. Hopefully I shed some light on this topic and answered your question somewhat.