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Smile is always good, there are many health benefits of smile. How many muscles of the face are exercised, I don't know exact number.
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There are about 36 named facial muscles and not all of them are used to smile. It takes about 12 to smile 11 to frown.
There isn't a definitive number. Facial expressions vary in the number of muscles that are used.
I believe the back of a matchox would say, "13 muscles to smile and 54 to frown; so why bother"? Or something like that? .... Cheers!
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