No single drug can cure the infection. The treatment is usually a proton pump inhibitor. This decreases the acid production in your stomach, which lets the damaged tissues heal.
Some proton pump inhibitor medicines are:
Two antibiotics are used; this reduces the risk of treatment failure and antibiotic resistance.
One medicine is usually the antibacterial and one the proton pump inhibitor. The main cause for the failure is due to antimicrobial resistance. A medicine called
clarithromycin seems to be the most important resistance because it is considered a first choice. Some cases have used multi(quadruple or triple therapies) with the medicines h amoxicillin-metronidazole or tetracycline-metronidazole. If the strain is resistant to these, then other combinations such as
amoxicillin-rifabutin, amoxicillin-levofloxacin or amoxicillin-furazolidone can be used. Even then...just amoxicillin can be used as the only antibacterial or
The most important resistance to consider is that to clarithromycin, since it is the first-choice antibacterial and clarithromycin resistance is highly clinically significant. Quadruple therapy or triple therapies with amoxicillin-metronidazole or tetracycline-metronidazole and a PPI or ranitidine bismuth can then be used despite a possible resistance to metronidazole if the strain is resistant to clarithromycin. Resistance to both clarithromycin and metronidazole may lead to the use of other combinations, i.e. amoxicillin-rifabutin, amoxicillin-levofloxacin or amoxicillin-furazolidone. Resistance to any of these drugs means their use must be avoided. In some instances, it may also be advisable to prescribe amoxicillin as the sole antibacterial, or to use a quadruple therapy with furazolidone instead of metronidazole.
it is theoretically possible to cure a drug-resistant H. pylori infection but apparently from a multi-drug standpoint so I would discuss a different approach with your doctor if nothing is working.
I took information from http://www.ncbi.nlm.nih.gov/pubmed/15329036