I had a raging case of reflux disease and was on several medications to control it. I HATE taking medications, so did everything in my power to reverse the reflux disease. Here's what worked for me:
Exercise daily - I run/powerwalk 3 miles EVERY day.
Eliminate foods that make the reflux worse. I had some surprises here. Hot dogs, pasta, coffee, take out foods (Yup, ALL of them). Find your triggers, eliminate them.
Reduce stress in your life: I was able to quit my job, most people can't, but you CAN start doing things like yoga, meditation, deep breathing exercises.
Drink water throughout the day. Make water your main source of fluid.
Don't eat anything several hours before you go to bed. Sip water.
In bed, raise the level of your head, try sleeping on your back or your LEFT side. Sleeping on your right side gives your digestive system the ability to drip acid continuously.
Hope these suggestions help! It's something you can do all of right away to see dramatic results.