Angelica Panganiban was born on November 4, 1986 in the Caloocan City, Philippines. Panganiban is a member of ABS-CBN's elite circle of homegrown talents properly named Star Magic. She started her career in showbiz at the age of 6 and first show was Ang TV. She was the Junior-Senior Prom Princess in 2002 and Miss Junior and Senior Prom in 2003.

Angelica's parents separated when she was two years old. She has no memories of her father. In her childhood, Angelica had thought that her grandfather, Alfredo Panganiban, was her real father.

Angelica appeared in the cover of Cosmopolitan Philippines in September 2006 and in the cover of FHM Philippines in March 2007. She is the Maxim Philippines' first cover girl.

Perhaps her most famous(also controversial) of her photos appeared in the 2007 Ginebra calendar. During her teen days, she had a a relationship with actor Carlo Aquino. She is currently in a relationship with model and actor Derek Ramsay