For many years, a fat cell was viewed as a balloon that fills up when you eat too many calories and is deflated when you eat less and burn more calories. But now with the discovery of leptin, ghrelin and adiponectin, it's pretty clear that fat is an endocrine organ that plays a dynamic and active role.

Scientist are scrambling to figure out exactly how fat cells influence our ability to lose or gain weight, play a key role in the immune system, and increase the risk of heart attacks, diabetes, and other diseases. To researchers, that extra bulge around your waist isn't a roll of flab, it's a cutting-edge science lab.

LEPTIN

Gain weight and your fat cells release more leptin. In theory that should make you eat less and burn more calories. But the fatter you get the less your leptin works. When you lose weight, your fat cells release less leptin. That makes you eat more and burn fewer calories, which makes it tougher to keepthe weight off.

GHRELIN

When you lose weight, your stomach (and not your fat cells), release more ghrelin, which makes you hungry, and makes it tougher to keep the weight off. It's a catch 22!

ADIPONECTIN

This "good guy" hormone enables insulin to hustle sugar from the bloodstream into your body's cells, where it's stored or burned for fuel. The more fat you have, the less adiponectin your fat cells secrete.

So what do we do? Just as I've always advocated, slowly return your weight to normal with nutritious foods and fun activities. And if your weight is already normal, keep it that way!

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