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Fibromyalgia and Gender

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By Iphigenia


Gender Differential in Fibromyalgia

Fibromyalgia, or more precisely the fibromyalgia syndrome, has become over the years the subject of much attention. This syndrome is a perfect model of pain and all its complexities. Never a week goes by without the publication of more research about the effects of different new treatments.

What the research is also revealing answers the questions posed in the title. Reseach into pain medecine has revealed that male and female sex hormones have very specific differences when it comes to the mechanics of pain and the experience of pain. Male hormones have a higher anti-nociceptive effect, which modulates pain, than female hormones. This could explain why women who have fibromyalgia seem to experience more pain than men who have also been diagnosed. That is that women have a lower pain threshold for this type of pain than men whose pain threshold is improved by pain inhibitors present in androgens – naturally occuring male steroid hormones.

This identification of hormonal influence on pain in fibromyalgia (and other conditions) has led to the research of treatments using neurosteroids which have sedative, relaxing effect. They are steroids which are synthesized directly in the nervous system and play a decisive role in the transmission and integration of sensory messages responsible for painful sensations. However, use of neurosteroids can inhibit the effect of anti-depressants. As some fibromylagia sufferers may also be prescribed anti-depressant medicine it is important to discuss this with the doctor.

Because of this counter indicative marker between neurosteroids and anti-depressants neurosteroids are not yet available as a pain treatment.

It is important to remember th fibromyalgia is a very complex syndrome which affects both the peripheral and central mechanisms of pain. The treatments for fibromyalgia are multiple and complementary. The belief that drug treatment alone will relieve this syndrome is an illusion. It is important for suffers to do some regular physical activity suited to their age and condition and irrespective of gender. Physical exercis has a central analgesic effect that may be even more effective than that of drugs.

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Julie-Ann Amos profile image

Julie-Ann Amos  says:
10 months ago

Useful hub and I like the images!

C. C. Riter  says:
10 months ago

Thanks for this. I must have Wee One give it a read. I know there are some Dr.s that don't even believe in this syndrome, a male thing I suppose and pure idiocy too. I sure hope the best for you for I know how it can totally disable women. Don't know of any men that are affilcted by it, my Family Physician thought I may have it, but not so. Good luck dear

The Real Tomato profile image

The Real Tomato  says:
10 months ago

An important topic indeed. My husband has FM and one of my friends brothers also. Definately not a womans condition.  I wish there were more clinical studies and research on FM - it is an awful affliction. Newest studies are suggesting that it is probably neurological - but more research is needed for sure! I hope I live to see the day a cure or successful treatment is available.

Thank you for bringing more attention and understanding to Fibromyalgia.

woodamarc profile image

woodamarc  says:
2 weeks ago

Your right without exercise activity, like walking, the meds are worthless. Let me give you a unique perspective.

I'm 1 in 10 men out of every woman that have been diagnosed with fibromyalgia. I'm a rarity since this is not common in men. I was diagnosed about 2 months ago after experiencing all tendor points since 2004. I could never figure out why my body began to hurt everyday, every joint for without reason. This was so frustrating. If it wasn't for my own research through the years and medical self-advocating to rule out everything from Parkinsons, lupus, cancer, MS, immune, nervous, etc., any less of a person may have just given up where the depression left them in worse shape. Fortunately I was to persistent for that.

My fibro came about per "doc's" characterizations of fibro secondary to military injuries while serving 22 years in two branches of service. I like to refer to this as massive internal damage that has cooked my pain receptors and rerouted super sensitivity back to my brain. Regardless my CNS with regard to pain tolerance is toast.

In my case, any form of anti-depressant for pain drug really messes up my head. I can't take them. So instead, I boost brain chems through daily walking. This helps alot. However, when I quite moving... Let the pain train begin.

I'm on a pain management program that does not include anti-depressants. In my opinion, those with previous neck injuries, or whole body injuries... Don't bank on anti-depressants wholly. If you feel crummy using them, get off of them! Find something else!

I've tried about everything the doc's recommended to include every specialist in the book, natural cures, etc., I call "poppycock" for those that had an amazing cure benefit... Most likely they experienced an acute characteristic fibro experience that was not pure fibro! True fibromyalgia is very difficult to diagnos.

I have to admit a rheumatologist-immune specialist is the closest to determining whether you have it or not and hold medical opinion weight over all other doc specialists, especially a primary physician.

The best thing one can do is take up a walking program, stretching, swimming, light weight reps to isolate and work indirectly around heavy pain trigger point(s) which vary in intensity on any one day. Oh yah, don't forget nutrition, but I won't go into this. This is my specialty to include exercise and pain management.

If you get a chance I'd appreciate you visiting my profile and a follow if you like my topics. I'm now following you. I think we have some similar interests.

You are correct, there is no cure, there is no known "exact" cause. Although science is working to fund studies around, previous injuries patients, depression, immune, IBS & most likely a whole aray of cause/origin possibilities.

I think those that try to profit off this selling snake oil should be ashammed of themselves. Because those that say their fibro diagnosed... And magically it disappears after using supplements, natural cures, etc., I'm highly skeptical of their intentions and for that matter... Who diagnosed them with Fibro? A primary physician. If so, that does not hold a whole lot of weight because any doc can state in the medical transcripts (characteristic of fibromyalgia... or like).

Good Write, and good point!

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