Anti-Endomysial Antibody (IgA)

Endomysium is the connective tissue stroma covering individual muscle fibers. Antibodies aid in the detection treatment of celiac sprue. Endomysial antibody and tissue transglutaminase (TTG) used to follow-up a positive gliadin IgA; TTG becoming the preferred test as it is less expensive and easier to perform. Gliadin IgA most useful for monitoring response to gluten free diet.

Anti-Gliadin (IgA and IgG)

Antibodies to aid in the detection of celiac spure. Gliadin IgA useful for monitoring response to gluten free diet. Endomysial antibody and tissue transglutaminase (TTG) preferred tests for diagnosis. Gliadin IgG can be positive, with a negative IgA, as IgA deficiency is associated with spure.

IgA

Immunoglobulin A is a component of serum gamma globulins. The primary6 antibody in saliva, tears mucous secretions and colostrums; with an important role in mucosal immune- protection. Used in the evaluation of immune deficiency states, monitoring IGA myeloma therapy and in the work-up of celiac disease.

TTG

Antibodies to transglutaminase. Aids in the diagnosis of celiac spure. Replacing endomysial and antigliadin test; less expensive and easier to perform with sensitivity and specificity> 95%. Consider obtaining IgA levels, as IgA deficiency is associated with celiac disease and may cause false negative.

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