Malignant mesothelioma The cancer of the mesothelial cells

The diseased defined

Mesothelium is the protective tissue that covers the chest cavity, abdominal cavity and the cavity around the heart and also produces a special lubricating fluid that allows the internal organs of the body to move around. Malignant Mesothelioma can be defined as the cancer of the mesothelial cells which become abnormal and start dividing without any order. Majority of the mesothelioma patients have a prior history of exposure to asbestos.

Types of malignant Mesothelioma

Malignant Mesothelioma or simply Mesothelioma can be divided into 3 main types namely

- Epithelioid

- Sarcomatoid

- Mixed/biphasic

Of these, Epithelioid is the most common (50% to 70% cases) and stands the best chance of recovery. Sarcomatoid type is seen in 7% to 20% cases whereas mixed/biphasic type is seen in 20% to 35% cases.

Approximately, ¾ of the total cases of Mesothelioma originates in the chest cavity (pleura) and is known as pleural mesothelioma. The cancer affecting the lining of the abdomen (peritoneum) is called the peritoneal mesothelioma and that affecting the "sac like" space around the heart (pericardial cavity) is called the pericardial mesothelioma. Mesothelioma at times also affects the covering layer of the testicles. However, the last two types of cases are quite rare.

Diagnosis of malignant Mesothelioma

The tumors of the mesothelium can either be benign (non cancerous) or malignant (cancerous). So whenever there are symptoms like shortness of breath, pain in chest/abdomen or swelling in the abdomen, you should consult your doctor immediately.

After the initial X-rays and scans, the doctor may look inside the chest cavity (in case of pleural tumor) with an instrument called thoracoscope and the test is called thoracoscopy. In case of tumor in peritoneum the doctor may go for peritoneoscopy with the help of a tool called peritoneoscope. Finally, if the abnormal tissue is found then a biopsy is done, whereby a piece of the unnatural tissue is cut out and placed under microscope for examination.

After the confirmed diagnosis of Mesothelioma it is also essential to ascertain its stages i.e. whether it is in localized stage or in advanced stage. In the localized stage, the cancer is found in the lining of the chest cavity or in the diaphragm or the lung. Advanced malignant Mesothelioma can again be divided into 3 stages namely stage II, III and IV. In stage II, the cancer spreads beyond the chest lining to lymph nodes and in stage III it spreads into chest wall, center of the chest, heart, through the diaphragm or abdominal lining, etc. The final or the fourth stage is the one in which the cancer has already spread to distant organs.

Treatment

Depending on the stage of the cancer, its location and the health, age and medical history of the patient, 3 types of treatments are mated out to malignant Mesothelioma patients - surgery (to remove the tumor), radiation therapy (application of high energy rays) and chemotherapy (usage of combination of drugs). This apart, if there is any accumulation of fluid in the chest or abdomen, then the doctor needs to drain it out and the process is regarded as thoracentesis and paracentesis respectively.

So be aware of the disease, such that you can prevent it at the very onset.

One of the fatal types of mesothelioma is Peritoneal Mesothelioma in which the cancerous cells attack the lining of the abdomen called Peritoneum. Peritoneum is the thin membrane, which shields various organs of the abdomen and also provides a lubricating fluid to enable the organs to move and work properly. Peritoneal Mesothelioma, which affects this lining, is yet now a relatively rare disease that accounts for about 1/5 of all mesotheliomas. Its only known cause in the U.S. till date is previous exposure to asbestos.

Major symptoms

Though Mesothelioma is neither age nor sex specific, peritoneal Mesothelioma is mostly seen in men who are in the age group of 50-70 years. There are a number of symptoms of peritoneal mesothelioma most of which start appearing after 20, 30 or 50 years after the exposure to asbestos. These symptoms may include weight loss (however, waist line may increase), pain or swelling in the abdomen, weakness, loss of appetite, bowel obstruction, anemia, nausea and fever. Also, fluid often accumulates in the peritoneal space leading to a condition called Ascites.

Diagnosis of peritoneal mesothelioma

The initial step towards detection of peritoneal mesothelioma includes X-rays and CT scans. For confirmed diagnosis, however the doctor needs to do biopsy whereby a piece of tissue is cut from the affected part of the victim's body and is placed under microscope for examination. If the disease is detected at an early stage it stands better chance of getting cured than the state of diffuse peritoneal mesothelioma, where the cancer has already spread to various parts.

The cure

It's true that peritoneal mesothelioma is fatal and leads to several deaths every year. However, with continued researches, several modes of treatments have been embarked upon and in the future there is a fair chance of the disease becoming absolutely curable. The types of treatment of peritoneal mesothelioma include surgery, radiation therapy and chemotherapy.

In surgery a part of the abdominal tissue is cut out to remove the tumor. At times the doctor may also need to remove a lung or a portion of the diaphragm as per the requirement of the surgery. Radiation therapy, the second method, requires the application of high energy X-rays to shrink the tumor and kill the malignant cells. The rays may be applied from an external machine or by placing the radiation source directly to the affected part of the body, by means of plastic tubes. Last treatment type is the chemotherapy whereby a combination of drugs is applied to kill the cancer cells. The drugs may be administered by mouth in the capsule form or may be applied intravenously via needle.

However, it is essential to mention that cost of treating any form of cancer is extravagant and you may consult a mesothelioma lawyer to earn you a handsome compensation from the authority who was responsible for your prior exposure to asbestos.

So learn more about peritoneal mesothelioma so that you can initiate the treatment at the very early stage and get cured.

What is Pleural Mesothelioma?

Pleural Mesothelioma or malignant pleural mesothelioma is cancer in the layer of the lungs that can spread to the lungs. The spread of the tumor over the pleura results in pleural thickening. This hinders the reflexivity of the pleura and encases the lungs in an increasing restrictive belt. With the lungs thus restricted, they get constricted in no time and a person is always out of breath.

Pleural mesothelioma can be:

- Diffuse and malignant (carcinogenic)

- Localized and benign (non-cancerous)

Benign pleural mesothelioma can be removed surgically, but the malignant tumors are the real terror heads.

Most common among other mesothelioma cases, Pleural Mesothelioma is caused due to exposure to blue asbestos for a longer period of time, say 20 years, in which time the disease incubates only to show its fearful countenance via certain symptoms.

The symptoms of Pleural Mesothelioma

The symptoms of Pleural Mesothelioma include difficulty in breathing, difficulty in sleeping, pain in the chest and abdominal regions, blood vomits, weakness, weight loss, loss of appetite, lower back pains, persistent coughing, hoarseness of voice, sensory loss and difficulty in swallowing.

Diagnosis of Pleural Mesothelioma

The first step is to go through a chest X-ray or a CT scan (computed chest tomograph), which will reveal a pleural thickening and an effusion. This is followed by a bronchoscopy. However, it should always be left to a medical practitioner for a better understanding of the respective cases. Another method is a biopsy, which can be a needle biopsy, an open biopsy, or a thoracoscopy, where a mini camera is inserted inside the body and with that a tissue sample is attained for further diagnosis.

Treatment of Pleural Mesothelioma

Treatment is directly proportional to the time of the revelation of the disease, i.e., at an early stage the tumor can be removed through surgery.

A pioneering mesothelioma treatment option is immunotherapy, e.g., intrapleural inoculation of Bacillus Calmette-Guerin (BCG) is a useful mesothelioma treatment in which an effort is made to intensify the immune response.

Radiation treatment and chemotherapy is probably then the answer to the malignant pleural mesothelioma, but this can aid the pain management only; there's no escaping death with Pleural Mesothelioma.

Side effects of Treatment

The side effects and penalty of mesothelioma lung cancer treatment are more than its treatment, which is damaged healthy tissues, a state of absolute fatigue ness; excessive radiation causes the skin to become red, dry and itchy.

Other side effects of radiotherapy are nausea and vomiting, diarrhea, urinary discomfort and a sudden reduction in the number of white blood corpuscles.

The average life span of a person with Pleural Mesothelioma is up to 6 months to a year and the maximum can reach up to 5 years - the magnesium-silicate mineral fibers take its toll that's more than painful.

Other factors that may accelerate the possibility of pleural mesothelioma are chronic lung infections, tuberculous pleuritis, radiation (Thorotrast), exposure to the simian virus 40 (SV40) or mineral fibers (Zeolite) and tobacco smoking to a certain extent.

Pleural Mesothelioma does not give a person the avenue for fair play. Though the existence depends much on the various stages of the disease, it is an ultimate killing menace that sucks out the life of the common man.

The pericardium is the mesothelial tissue that surrounds and acts as a safeguard to the heart. The pleural mesothelium membrane covers the lungs and chest cavity and peritoneum is the mesothelial tissue that enfolds the organs in the abdominal cavity.

What is actually cancer mesothelioma?

Mesothelioma is a type of cancer that affects the mesothelium, a dual layered membrane with which our chest, lungs, abdomen and the heart is wrapped safely.

Cancer Mesothelioma can damage any of these cells, although pleural mesothelioma is more common; it metastasizes and at an advanced stage the disease reach to the other parts of the body like the lymph nodes, lungs, chest wall, or abdominal organs.

How is cancer mesothelioma caused?

Though asbestos exposure is the primary reason in 70% to 80% of the cases, mesothelioma can be caused by other means, like exposure to the chemical zeolite that is also present in asbestos.

Asbestos has become part of our daily life being in cement, brake linings, roof shingles, flooring products, textiles, and insulation. The asbestos fibers take their toll by going into our windpipe and settling in the internal organs causing the formation of carcinogenic tumors.

The overall scenario regarding cancer mesothelioma

Though there is a ban on certain asbestos products, around 1000 people in France and above 2000 people in the U.S are faced with this nightmare each year.

Mostly, workers from shipyards, asbestos mines and mills are prone to this mishap, due to a constant exposure to asbestos. However, it takes 30 to 50 years for the disease to surface and show symptoms though they are not always accurate.

Cancer mesothelioma is proving more than a menace and the average person live for 12-24 months; the earlier it is detected, the better is the cure process.

The recent picture

Today, the U.S. Occupational Safety and Health Administration (OSHA) have put restrictions towards maintaining acceptable levels of asbestos exposure in the workplace. People who work with asbestos are geared up with individual protective equipment to lower their risk of exposure. Even the family members of the workers are prone to the disease, so they are advised to take a shower before leaving for home.

Symptoms of cancer mesothelioma

- Feeling out of breath and pain in the chest due to an accretion of fluid in the pleura

- Peritoneal mesothelioma comprises weight loss and abdominal pain and a bulging abdomen due to accumulation of fluid

- Bowel obstruction, blood clotting abnormalities, anemia, and fever

- Pain, trouble swallowing, or swelling of the neck or face

However, a registered medical practitioner can diagnose you correctly.

Diagnosis of cancer mesothelioma

Diagnosis commences with an assessment of the patient's medical history, as well as any history of asbestos exposure. A complete physical examination may be performed, including:

- X-rays of the chest or abdomen

- A CT (or CAT) scan or an MRI may also be useful. A CT scan is a sequence of comprehensive pictures of areas inside the body created by a computer linked to an X-ray machine

- In an MRI, a strong magnet connected to a computer is used to draw meticulous pictures of areas affected by cancer mesothelioma inside the body. These pictures are viewed on a monitor and can also be printed

- A biopsy regarding the taking out of a sample tissue for examination is needed to verify a diagnosis of mesothelioma. Types of biopsy depending on the location of the tumor are thoracoscopy, peritoneoscopy

Lastly, the stage of the disease is important to the doctor for the correct diagnosis.

Cancer mesothelioma treatment

Treatment of cancer mesothelioma yields results depending on the site of the cancer, the phase of the disease, and the patient's physical condition. The usual treatments for cancer mesothelioma are surgery, radiation therapy, and chemotherapy. Occasionally, these treatments are combined.

Surgery is an effective way to remove tumor but the age of the person matters. Radiation therapy and chemotherapy are good ways to ward off the symptoms.

Often, high-end drugs are given to the patient to reduce the fluid formation in body.

Thus, it is better for the workers to get a medical check up at equal intervals and be aware of its symptoms. If a patient is diagnosed with cancer mesothelioma at the earliest stage, the treatments might do wonders for him.

Mesothelioma lawsuits are filed by the victims of mesothelioma to avail reparations for medical expenses, pain & suffering and loss of income associated with the growth of this disease. Mesothelioma is a kind of cancer, which is inflicted by exposure to asbestos most frequently used in industrial and residential places till the late seventies. The numbers of mesothelioma victims were on the rise as the employers continued using these hazardous materials despite knowing the harmful consequences of them. Thus the poor workers, who were ignorant of the potential health risks that they were about to confront, were the unfortunate victims.

In case the victim dies there is a provision that one of the family members or the executor of his estate can file the lawsuit. On the other hand a family member who has contracted the disease from the victim of mesothelioma can also file a lawsuit.

Thus, if an individual is victimized owing to the negligence of another person, he has absolute right to take legal actions in the court of law for compensation. An individual needs to first consult with an attorney who deals with asbestos litigation and on his discretion the victim can file the suit.

How long does the process take and what are the end results?

These lawsuits tend to be cumbersome and longwinded. It could also stretch to years even to reach any settlement. Again all lawsuits are not necessarily longwinded; some of them take lesser time. However, in some of the cases the victims receive negligible amount of money, most of which are used to meet the lawyer's and the court's expenses. Nevertheless victims of mesothelioma should exhibit their rights and fight for their compensation. Again, mesothelioma lawsuits are generally settled out of court before they are set for trail. This actually makes more sense because it curtails court expenses for both the parties.

What can you do if you are uncertain about exposure to asbestos?

If you don't know where and when you were exposed to asbestos, you should speak to your lawyer who will help you out. The lawyer may possibly hire a professional investigator who can make the necessary investigations so as to find out where the exposure had occurred and who are the ones that can be held responsible.

How much do you have to pay?

Factually, you need not pay unless and until you receive your compensation. It is only then that your lawyer shall take a percentage out of the compensation as his remuneration.

How much can you expect as compensation?

Well it depends on how creditable your case is. You will find that past settlements amounted to quite a ransom. But in the recent past with the subsequent increase in the number of mesothelioma lawsuits, there is a sleek chance to realize the entire amount.

The history of mesothelioma lawsuits

According to U.S mesothelioma history, the first ever mesothelioma lawsuit was filed in 1966 against the careless use of asbestos. But unfortunately the verdict went against the case. For the second time, another suit was put forward for a co-worker and this time the case was won. This gave impetus to all those helpless victims who craved for justice as innumerable mesothelioma lawsuits cropped up simultaneously.

Mesothelioma lawsuits also tells us that how ignorant people were initially about the causes and the aftereffects of the deadly disease. But now with the intervention of the law firms the victims of mesothelioma are provided with all-round assistance as regards lawful solutions to their righteous problems.