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My Response to a Patient With Severe Anxiety Symptoms from Hypothyroidism

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By JimLow



 

This week, I was e-mailed by a lady who has hypothyroidism and she is struggling with severe anxiety from the disease that is causing her low-functioning thyroid. She wrote, asking my opinion about thyroid removal, also called thyroidectomy and if I felt this was an option for a patient with severe, unresolved anxiety symptoms from hypothyroidism. She also asked about thyroid transplantation (a good question) and if this had been researched by the medical community. Below, I'm posting my response to her on these questions, plus I provided her some links to medical research that confirms anxiety as a symptom in hypothyroid patients and that you do not have to have an overactive thyroid to experience severe anxiety but that thyroid hormone imbalance of any type can potentially cause it.

MY RESPONSE:

Yes, even thyroid disease that causes hypothyroidism can cause anxiety and anxiety disorders. There are research articles out there that plainly state this but many Doctors don't know about these and will tell their patients that their anxiety symptoms are not related to their thyroid disease. The fact is, the "autoimmune" type of hypothyroidism, called "Hashimoto's thyroiditis" and the most common cause of hypothyroidism, can cause anxiety problems. Some patients with Hashimoto's go through spells of hyperthyroidism and the medical term for this is "Hashitoxicosis" however, some patients do not have this intermittent hyperthyroid condition going on and their Hashimoto's still causes them anxiety symptoms. Even patients with "sub-clinical" hypothyroidism, experience severe anxiety states because many Doctors will not treat them at this stage of the disease and they will experience severe anxiety from the fluctuating hormones, as you described in your e-mail.

Here are just a few article-links, with my short description of what they state, that confirm anxiety problems with autoimmune hypothyroidism.

This link to an article entitles "Anxiety and Endocrine Disease", is by Richard C. W. Hall, M.D. Clinical Professor of Psychiatry University of Florida and he states in this article that in patients studied in medical research, which he has done for John Hopkins Medical University, among others, that patients with Hashimoto's thyroiditis, exhibited anxiety as the initial and most prominent symptom upon diagnosis.

Here's that link, look at the 8th paragraph under the heading "Anxiety and hypothyroidism".

Click here>> www.drrichardhall.com/anxiety.htm

This next article link entitled ""A case control study on psychiatric disorders in Hashimoto disease and euthyroid goitre: not only depressive but also anxiety disorders are associated with thyroid autoimmunity", states that Hashimoto's thyroiditis or the type of thyroid autoimmunity that causes hypothyroidism, has the potential to cause "anxiety disorders" in addition to depression.

Click here>> http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1308833

These are only a couple out of many others, in fact one other I would mention, is a medical research study done by the Endocrine Society in Japan, where they conclude in their study that even sub-clinical hypothyroidism can potentially cause severe anxiety symptoms. This one is entitled "Assessment of Anxiety in Sub-clinical Thyroid Disorders".

click here>> http://sciencelinks.jp/j-east/article/200415/000020041504A0523037.php

Now, in regard to having a thyroidectomy (removal), they do opt for this surgery in hypothyroid patients but only as a last resort and only if they cannot get them to remain level on their thyroid hormone replacement medication. An important thing to be assured of, is that your Doctor is adequately treating your hypothyroidism. One way to make sure, when you are having ongoing symptom problems, is to get a second opinion. You do this by getting an appointment with a qualified Endocrinologist or Thyroid Specialist, and provide him with your blood lab results history, which will include the levels your thyroid hormones have been treated to on your medication. If the second Doctor feels you're a rare patient who cannot be adequately treated to keep your thyroid hormones level, he would then discuss with you the thyroid removal possibility. They don't have thyroid transplantation right now but could be a possibility some day.

I hope this info helps!

Sincerely,

Jimlow
 

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Jennifer  says:
2 years ago

I know about Hoshimoto's and anxiety first-hand. I am 27 and was diagnosed by my family practitioner with hypothyroidism about 3 and a half years ago. Treatment with levothyroxine did nothing for me and I came up on some situations where I was unable to continue treatment. About a year ago, I started having problems with paranoia. Feeling like the sky was heavy and the air was weird and I was being followed or watched. I started seeing an endocrinologist about six months ago and she is helping a lot. I could not take Synthroid because it gave me migraines (not common or common knowledge as a possible side effect). She has me up to 125mcg of levothyroxine and I have no more headaches. I do still have a very large goiter, which has been with me at least since I was six. The only thing they can do about that at this point is to remove it. I am looking for ways to find out baout other people who have made the decision for removal, both good and bad. Please let me know if you have any ideas of where to find these people and their stories.

JimLow profile image

JimLow  says:
2 years ago

Hi Jennifer,

There is research out there that concludes that people with autoimmune thyroid disease, not only can have anxiety and depressive disorders but can experience conditions that mimick psychosis, especially when they experience "Hashitmoto's Encephalopathy" which is somewhat rare but can happen when antibodies become extremely high. Hashimoto's patients do more commonly go through emotional states that mimick bipolar disorder.

There is a thyroid forum called the Thyroid Disease Chat Center (free non-profit) and I was a moderator for about a year and a half but just recently asked to be placed back to member status, due to insufficient time to moderate. I've posted there, over 2,600 times and is the best thyroid forum that exists on the web. If you post about your experience on there, you'll get replies from people who share your experiences with thyroid disease.

here's the link>> http://thyroidhost.proboards30.com/

Jennifer  says:
2 years ago

Thanks for the info, Jim. Sorry it took me so long to get back in touch. I have recently decided that things are not improving and am getting in touch with my doctor to discuss a thyriodectomy. I am guessing that this part of the process will move no more quickly than the rest has, but I hope that it will alleviate more of my symptoms. I have been looking for reactions from people who have done it, both good and bad. I will check out the discussion board.

C-Marie  says:
7 months ago

I had a huge goiter and had to have a Total Thyroidectomy. The surgeon thought I wouldn't have adverse side effects, so she didn't make mention of what I would could go through. On surgery day, I was three weeks post partum and so my world was turned upside down and I mean that in the literal sense. Depression, weight gain, mood swings to beat all, and horrible TSH levels. This was almost five years ago. I got past the depression on my own, and still face the weight problem, mood swings, and have switched from Synthroid to Armour Thyroid due to a lot of edema problems. After a year and a half of being on Armour, my body is starting to become intolerant to that as well.

I have asked for help with my weight loss but have heard nothing but "Proper diet and exercise is key." I've been doing that for years, and am still very over weight. Life before my total is a total opposite to what I'm living with now. It's as if my body is screaming for help, and I'm not sure how to go about making things better. Something has to give.

JimLow profile image

JimLow  says:
7 months ago

C-Marie,

I'm a stickler for making sure a doctor is treating hypothyroidism adequately and even optimally because i feel it's the most important thing to look at first. With a thyroidectomy or radio active iodine destruction of the thyroid, afterward you become hypothyroid, not having a gland. The goal of a treating doctor is to suppress the TSH level (blood level of Thyroid stimulating Hormone that comes from the pituitarty/brain gland) to lowest-normal when a person has no gland. It is also important in my opinion that the T3 and T4 thyroid hormones be blood retested to see where they are as well. If these are not kept at mid range on up to higher-normal, you may be inadequately treated. Suppressing TSH alone does not always reveal where the thyroid hormone levels are.

You can only know how well a Dr. is treating, by asking for copies of your lab results (U.S. HIPPA law obliges them to provide copies when requested), monitoring your replacement hormone treatment. If your current Dr. is not adequately treating, I would seek a second opinion. TSH runs in a range of about  "0.3 to 5.0" and with replacement thyroid hormone, after thyroidectomy the TSH should be at the lower end of that. If it's not, less symptom relief may be experienced.

I hope that helps and I wish you the best with it! 

EN KAY  says:
4 months ago

I RECENTLY HAD A SUB -TOTAL THYROIDECTOMY -THREE MONTHS AGO ,THE DOCTORS MADE ME BELIEVE THAT IT WULD BE BETTER IF I REMOVED THE GOITRE BECAUSE IT WAS SMALL AND TO AVOID IT GETTING BIGGER. I FEEL BETTER NOW AND I WAS PLACED ON LEVOTHYROXINE TOO DONT KNOW WEN I WUD STOP TAKING IT COS I M GETTING FED UP. I HEAR PEOPLE COMPLAIN OF BEING OVERWEIGHT AFTER THE SURGERY BUT I M STILL SAME SIZE., NOT REALLY DEPRESSED BUT WEN I LOOK AT MY NECK I JUST FEEL HEY ,I WULD HAVE BEEN UNDER SIX FEET BY NOW SO I JUST FORGET ABOUT THE SCAR.I ONLY FEEL TIGHTEENING IN MY NECK WHEN I WAKE UP FROM SLEEP EVERY MORNING.

I JUST HOPE THIS SERVES AS AN ENCOURAGEMENT TO THOSE WHO HAVE GOITRE. PLS REMOVE IT IF ITS STILL SMALL AND FOLLOE DOCTORS ORDERS.

THANKS ALL

JimLow profile image

JimLow  says:
4 months ago

Thanks for commenting and sharing your experience.

Most doctors don't refer a patient with goiter for thyroidectomy, partial or full, unless they see likelihood, that it may at some point obstruct breathing or swallowing. They also refer for surgery in cases of thyroid nodules for the same reason or if they are suspicious for malignancy.

Yours very likely was in one of those categories and sounds like you're getting good post-op treatment as well.

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