Absolutely not. Well, at least not in the traditional way.
Let's assume that human and Kryptonian DNA are compatible - unlikely as we would need to assume some kind of common evolutionary path. But, let's assume for the sake of argument that somehow, human DNA and Kryptonian DNA are compatible. If Superman and Lois used the traditional way of mating, Superman would be subject to the same loss of control that men have in "arrival".
Superman has always viewed his strength level to be like working within a house of cardboard. Given that he needs to control his strength ever moment of his waking existence, a moment of lost control could be fatal to any Earthling. This involuntary muscle movement of "secretion" during a sexual climax would pack a force akin to the velocity of a 9mm bullet, easily killing Lois in the process.
No, the only way for Superman to impregnate Lois is through a method of artificial insemination. Provided that semen and egg are compatible, the fertilized egg would need to be placed back within Lois in a sunlight free environment. It is fortunate that the fetus would not be exposed to yellow sunlight throughout the term and the labor. Superman's powers (post crisis) developed very slowly and Lois could survive the rigors of childbirth.
The trick is getting through the conception.