I would say "yes." I belong to a world Buddhist organization called Soka Gakkai International, a non-Governmental organization within the United Nations, where there are 12 million practicing Nichiren Daishonin's Buddhism. Our premise is about compassion for humanity. We help ourselves and others and both goals help change our karma. President Ikeda has changed the world by making his annual peace proposals, and many of his ideas have been adopted. For example, SGI is involved in awareness-raising and public education focusing on peace, disarmament, human rights and sustainable development. The organization came up with Victory over Violence due to the tragic killings at Columbine High School shootings that occurred on April 20, 1999. With technology and the internet, we have websites full of reading materials so that nobody really needs to buy any books if they don't want to. All of Nichiren Daishonin's writings are online for free, but one can purchase them all at the centers' bookstores. Because this practice is based on actually proof, it is encouraging to see efforts made through out the world regarding individual changes called "human revolutions" versus world changes. President Ikeda has been a person with over 300 honorary degrees and he has created dialogues with controversial leaders and countries in order to forge ahead and improve humanity. In the mid90s I went to London. Before I went, I asked my friends to contact their friends. I had great insight into a Londoner's life and Buddhist practice that I would never have received if I were an average tourist, particularly from a country full of people who meet one another at pubs rather than people's homes.
I cannot say for other organizations, but from what I see on CNN heroes, there are many organizations that are helping humanities in all sorts of ways.