The world is still going to be here. The human race (or large parts of it) can go at any time -- before, during, or after 2012.
Let's see, we have the Muslims looking to trigger the final battle. Ditto a lot of Christians. The totally wacko Christians are not in charge, so they probably won't start it. OTH, the wacko Muslims are in charge -- or nearly so -- soon becoming in charge -- of those countries, so as soon as one or another, such as the mullahs in Iran get and get control of nuclear weapons and delivery systems, BOOM!
Then, there is world-wide dependence on an electronic infrastructure that can be wiped out at any moment by a huge solar flare, or crazy N. Koreans or Muslim crazies setting off an EMP bomb over Kansas, launched from the Gulf.
Then, speaking of the Gulf -- fishing there supplies (supplied) a large percentage of food. Forget about that for a few years. So what you gonna eat in the meantime? Also, perhaps a huge methane belch that could suffocate millions in the Gulf area.
Then there is the pending collapse of fishing worldwide, not just the Gulf, because of overfishing.
Then there are the cumulative effects of all the chemicals we are all exposed to in food and stuff we handle every day.
Enough for now?
Most of these problems are caused by culture and religion, which has led to these problems caused massive overpopulation.