Which one is profitable investing in stock or in real-estate?

Investing in stocks can yield much greater returns than property but as with such things, higher potential returns can also lead to much higher levels of risk.

As Mariyamma says, real estate is a much safer investment over the long haul (although it's not entirely safe - look into negative equity as evidence of this), whereas stocks may be preferable for shorter term investments if you don't mind carrying the additional risk.

Real estate is safe and profitable if you want to make a long term investment.

I would say the question is not which one is more profitable, but which investment works for your personal risk level and investment plan. Both are very profitable, but it still comes down to does the individual have the education, talent, and stomach to invest in one or the other. I prefer stocks simply because my assets are very liquid. I can close a position with the push of a button. I also believe that every investment has its time and know is the time to buy real-estate.