Yes it can work, if he is is legal.
Younger men are turned on by the confidence and the lady like nature of an older woman. She must be careful not coddle him like a child. He won't like being reminded of how young he is every time she opens her mouth. No matter how young he is he will want to be treated like a man in the relationship.
And older woman loves the adventure of a younger man. He must realize that in most cases she has "been there, done that". She is looking for something fresh and new. If she is much older, her independence goes beyond sexy, it is her life style. Getting to the place where she trust you enough to let you take care of her will not come easy.
If the two can understand each other, just like any other relationship, it will work. Age is just a number, but time and patients is any relationships friend.