Well, there hasn't been a second time for me, so I couldn't tell you on a personal level.
Now, on a philosophical level the answer is: perhaps, maybe, or possibly.
Who can know for sure? Does it not depend on the parties involved? Does it not depend on how open one is to love and what each party is willing to give?
Much of the answer depends on the other party and how they make you feel. It also depends on how receptive one is to love and intimacy. It also depends on if you have a better knowledge of yourself and have chosen more wisely the second time around.
Moreover, it depends on how much the two of you have in common and how much you have invested in each other. Let us also not forget the character of the parties involved taking into consideration their strengths and weaknesses.
Really there are so many variables that answering this question proves difficult, except on a philosophical level. But, in the end, only time will tell. :0)