When you say MAN do you mean MANKIND?
Hi good day
Lovely question :)
Well if it's mankind yes i would say some have lost their humanity towards others.
Lack of love
Lack of care
Lack of kindness
Lack of giving
Lack of reaching out to others in general.
Lack of prayer and belief, etc
Also one of the biggest lost is the one to become so evil to lose every drop of human feelings for another human where you can murder, rape, stab and hack to death without any care in the world, feeling no remorse of what you have done.
Mankind has fallen lower than the animals