My earliest inking of pain and anguish was an ontological dream at age 2 or 3. It was a nightmare which started rather blissfully, suddenly understanding an ancient Truth that allowed me to take flight. But then Faith turned to Doubt, and I began to sink. Dark claws reached up to grab me and I awoke, kicking my covers off to keep the sharp talons from touching me.
All suffering comes from Ego -- self-concern. Christ said it best when he told us that the First (egoist) shall be last, and the Last (humble and loving) shall be first. When we love without any self-concern, Christ hears us. The heavens open up and miracles occur.