3D Printers in Medicine: Amazing Technology and Uses

Researchers have made ears with the help of a 3D printer.
Researchers have made ears with the help of a 3D printer. | Source

Exciting Creations

3D printing is an exciting innovation in technology and has many useful applications. One fascinating and potentially very important use of 3D printers is the creation of materials that can be used in medicine. These materials include medical devices, artificial body parts and body structures made of living cells. In the future, entire organs may be created by 3D printers.

3D printers have the ability to print solid, three dimensional objects based on a digital model stored in a computer's memory. A common printing medium is liquid plastic that solidifies after printing, but other media are available. These include "inks" containing living cells.

The ability of 3D printers to produce materials that are compatible with the human body is improving rapidly. Some of the materials are already used in medicine while others are still in the experimental stage. Many researchers are involved in the investigation. 3D printing has the tantalizing potential to transform medical treatment.

A 3D Printer in Action

How Does a 3D Printer Work?

The first step in the creation of a 3D object by a printer is to design the object. This is done in a CAD (Computer Aided Design) program. Once the design is finished, another program creates instructions for producing the object in a series of layers. This second program is sometimes known as a slicing program or slicer software, since it converts the CAD code for the entire object into code for a series of slices or horizontal layers. The layers may number in the hundreds or even in the thousands.

The 3D printer creates the object by depositing layers of material according to the slicer program's instructions, starting at the bottom of the object and working upwards. Successive layers are fused together. The process is referred to as additive manufacturing.

Plastic filament is often used as a medium for 3D printing, especially in consumer-oriented printers. The printer melts the filament and then extrudes hot plastic through a nozzle. The nozzle moves in all dimensions as it releases the liquid plastic in order to create an object. The movement of the nozzle and the amount of plastic that is extruded are controlled by the slicer program. The hot plastic solidifies almost immediately after it's released from the nozzle.

Structure of the Ear

The ear consists of more than just the visible part.
The ear consists of more than just the visible part. | Source

The part of the ear that is visible from the outside of the body is known as the pinna or auricle. The rest of the ear is located in the skull. The function of the pinna is to collect sound waves and send them to the next section of the ear.

Making an Ear by 3D Printing

In February 2013, scientists at Cornell University in the United States announced that they had been able to make an ear pinna by 3D printing. The steps followed by the Cornell scientists were as follows.

  • A model of an ear was created in a CAD program. The researchers used photographs of real ears as the basis for this model.
  • The ear model was printed by a 3D printer, using plastic to create a mold with the shape of the ear.
  • A hydrogel containing a protein called collagen was placed inside the mold. A hydrogel is a gel that contains water.
  • Chondrocytes (cells that produce cartilage) were obtained from a cow's ear and added to the collagen.
  • The collagen ear was placed in a nutrient solution in a lab dish. While the ear was in the solution, some of the chondrocytes replaced the collagen.
  • The ear was implanted in the back of a rat under its skin.
  • After three months, the collagen in the ear had been completed replaced with cartilage and the ear had maintained its shape and distinction from the surrounding rat cells.

A 3D Printer Helps to Make an Ear

Difference Between a Mold and a Scaffold

In the ear creation process described above, the plastic ear was an inert mold. Its sole function was to provide the correct shape for the ear. The collagen ear that formed inside the mold acted as a scaffold for the chondrocytes. In tissue engineering, a scaffold is a biocompatible material with a specific shape on and in which cells grow. The scaffold not only has the correct shape but also has properties that support the life of the cells.

Since the original ear creation process was performed, the Cornell researchers have found a way to print a collagen scaffold with the correct shape needed to make an ear, eliminating the requirement for a plastic mold.

Rib cartilage (shown in red) is sometimes used to make a replacement ear.
Rib cartilage (shown in red) is sometimes used to make a replacement ear. | Source

Potential Benefits of Printed Ears

Ears made with the aid of 3D printers could be useful for people who have lost their own ears due to injury or disease. They could also help people who were born without ears or have ears that haven't developed properly.

At the moment, replacement ears are sometimes made from cartilage in a patient's rib. Obtaining the cartilage is an unpleasant experience for the patient and can damage the rib. In addition, the resulting ear may not look very natural. Ears are also made from an artificial material, but once again the result may not be completely satisfactory. Printed ears have the potential to look more like natural ears and to work more efficiently.

Human Skull Bones

An artificial mandible, or lower jaw, has been created by a 3D printer.
An artificial mandible, or lower jaw, has been created by a 3D printer. | Source

In March 2013, a company called Oxford Performance Materials reported that they had replaced 75% of a man's skull with a 3D printed polymer skull. 3D printers are also used to make health care appliances, such as prosthetic limbs, hearing aids and dental implants.

Printing a Lower Jaw

In February 2012, Dutch scientists reported that they had created an artificial lower jaw with a 3D printer and implanted it into the face of an 83-year-old woman. The jaw was made from layers of titanium metal powder fused by heat and was covered by a bioceramic coating. Bioceramic materials are compatible with human tissue.

The woman received the artificial jaw because she had a chronic bone infection in her own lower jaw. Doctors felt that traditional facial reconstruction surgery was too risky for the woman because of her age.

The jaw had joints so that it could be moved, as well as cavities for muscle attachment and grooves for blood vessels and nerves. The woman was able to say a few words as soon as she woke up from the anesthetic. The next day she was able to swallow. She went home after four days. False teeth were scheduled to be implanted into the jaw at a later date.

Bioprinting with Living Cells - A Possible Future

Printing with living cells, or bioprinting, is happening today. It's a delicate process. The cells mustn't get too hot. Most methods of 3D printing involve high temperatures, which would kill cells. In addition, the carrier liquid for the cells mustn't harm them. The liquid and the cells that it contains is known as a bio-ink (or a bioink).

Organ and Tissue Replacement

The replacement of damaged organs with organs made from 3D printers would be a wonderful revolution in medicine. At the moment there aren't enough donated organs available for everyone who needs them.

The plan is to take cells from a patient's own body in order to print an organ that they need. This process should prevent organ rejection. The cells would be stem cells, unspecialized cells that are capable of producing other cell types under certain conditions. Stem cell biology is another exciting area in medical research. A knowledge of stem cells is essential in order to create printed organs.

A special type of 3D printer known as a bioprinter is used to make living tissue. In general, a hydrogel is printed from one printer head to form a scaffold. Tiny liquid droplets, each containing many thousands of cells, are printed on to the scaffold from another printer head. The droplets soon join and the cells become attached to each other. When the desired structure has formed, the hydrogel scaffold is removed. It may be peeled away or it may be washed away if it's water soluble. Biodegradable scaffolds may also be used. These gradually break down inside the human body.

Organ Printing Research

Bioprinting Successes So Far

Non-living implants created by 3D printers are already used in humans. The use of implants containing living cells requires more research, which is being performed. Entire organs can't yet be made by 3D printing, but sections of organs can. Many different structures have been printed, including patches of heart muscle that are able to beat, skin patches, segments of blood vessels and knee cartilage. These haven't been implanted into humans yet, however.

Some hopeful research results were reported in 2016. A team of scientists implanted three types of bioprinted structures under the skin of mice. These included a baby-sized human ear pinna, a piece of muscle and a section of human jaw bone. Blood vessels from the surroundings extended into all of these structures while they were in the bodies of the mice. This was an exciting development, since a blood supply is necessary in order to keep tissues alive. The blood carries nutrients to living tissues and takes away their wastes.

It was also exciting to note that the transplanted structures were able to stay alive until the blood vessels had developed. This feat was accomplished by the existence of tiny pores in the transplanted structures that allowed nutrients to enter them.

Printing Parts of the Heart

Some Challenges for Bioprinting

Creating an organ that is suitable for transplantation is a difficult task. An organ is a complex structure containing different cell types and tissues arranged in a specific pattern. In addition, as organs develop during embryonic development, they receive chemical signals that enable their fine structure and intricate behaviour to develop properly. This signals are lacking when we try to create an organ artificially.

Some scientists think that at first - and perhaps for some time to come - we will print implantable structures that can perform a single function of an organ instead of all of its functions. These simpler structures may be very useful if they compensate for a serious defect in the body.

It's possible that bioprinted structures will be good enough for testing new medical treatments before they are ready for transplantation. This in itself could be an important breakthrough because it could reduce the use of lab animals.

The Future for Bioprinting

Though it's likely to be years before bioprinted organs are available for transplants, we may well see new benefits of the technology before then. The pace of research seems to be increasing. The future of 3D printing in relation to medicine should be very interesting as well as exciting.

References and Further Reading

© 2013 Linda Crampton

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Comments 26 comments

billybuc profile image

billybuc 3 years ago from Olympia, WA

That is so incredible I don't even know what to say about it. Now there is a first...billybuc is speechless. LOL Technology has advanced into the Star Wars realm now. Thank you for a fascinating bit of information.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

I agree, Bill - this is incredible! The future should be very exciting. It will be so interesting to see what develops from 3D printing technology. Thanks for the visit.


drbj profile image

drbj 3 years ago from south Florida

This information is truly mind-blowing, Alicia. It's almost as if science has stepped through Alice's Looking Glass to find ways in which 3D printers can benefit human beings with new ears, jaws, prosthetics and who knows, perhaps one day even human organs. Excellent research, m'dear, and voted Up!


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thanks for the comment and the vote, drbj. The potential of 3D printers is mind-blowing! Some people are predicting that as the printers become less expensive more people will buy them, which will change the way in which we obtain manufactured goods in our lives. The early signs with respect to their abilty to treat medical problems are very hopeful, too.


bdegiulio profile image

bdegiulio 3 years ago from Massachusetts

Hi Alicia. I have heard of this technology. In the aerospace industry they are testing this to make solid models. It looks like the sky is the limit for this exciting new technology. Can't wait to see where it takes us? Great job. Voted up, shared, etc.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thanks for sharing the information, Bill. Yes, the technology does offer amazing possibilities! It will be very interesting to see how it develops over time. Thank you very much for the vote and the share.


Stephanie Henkel profile image

Stephanie Henkel 3 years ago from USA

The whole concept of printed ears and body organs is just other-worldly! The advances in science and medical science are unbelievable! Your article is fascinating, and it's a bit mind boggling, too, to think that these sci fi concepts are actually becoming reality. Great on job writing and researching this article!


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Hi, Stephanie. "Other-worldly" is a great way to describe the amazing medical possibilities of 3D printers! Thank you very much for the visit and the comment.


FlourishAnyway profile image

FlourishAnyway 3 years ago from USA

This is truly amazing, almost beyond comprehension. I heard about this but did not bother to seek out additional information. Thanks for supplying it in an engaging, easy to understand format.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thanks for the comment, FlourishAnyway. I appreciate it! I hope the medical possibilities of 3D printing become realities. The results obtained so far are very promising.


kashmir56 profile image

kashmir56 3 years ago from Massachusetts

Hi my friend great article, I have see these printers in action on videos and it is pretty amazing what they can do. Thanks for all the informative information it was very interesting to read. Well done !

Vote up and more !!! Sharing !


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Hi, Tom. Yes, these printers are amazing! They have so many uses. I think their medical applications are especially interesting. Thank you very much for the votes and the share!


aviannovice profile image

aviannovice 3 years ago from Stillwater, OK

This is quite remarkable, and it sure makes things a lot easier, less chance for errors, too. Great workup!


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Hi, Deb. Yes, the abilities - and potential abilities - of 3D printers with respect to medicine are remarkable! Thank you for the visit and the comment.


Fossillady profile image

Fossillady 3 years ago from Saugatuck Michigan

This is promising and remarkable information. Just think, a few years from now, if they could replace the lungs and heart. Glad, I learned of this today!


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Hi, Kathi. I agree - this is very promising technology. I'm looking forward to the future!


shiningirisheyes profile image

shiningirisheyes 3 years ago from Upstate, New York

Absolutely remarkable how far technological advancements have reached. So many benefit from these beneficial concepts. Great article.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Hi, Beckie. It is amazing to see how far technology has progressed! The future should be exciting. Thanks for the visit.


Insightful Tiger profile image

Insightful Tiger 3 years ago

This is absolutely fascinating! I was just watching a show on how one could make a working gun with one of these. From your article I can see that there are many benefits as well. Well done! Voted up and interesting.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you very much for the comment, Insightful Tiger. I've heard about the gun too, but I'm not happy about the use of 3D printers for this purpose. The medical applications of the printers are wonderful, though! I appreciate your visit and votes.


Glenn Stok profile image

Glenn Stok 3 years ago from Long Island, NY

I find it interesting that we are already living in an age where the possibilities are becoming "real" for enabling the creation of working body-parts for organ transplants by using stem-cell 3-D printing.

We have so much to look forward to. You did a great job in researching this and writing about it with so much detail. Voted up.


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you very much for the comment and the vote, Glenn. I agree - there is so much to look forward to in 3D printer technology! The future should be very interesting and very exciting.


Ingenira profile image

Ingenira 3 years ago

Amazing technology and printer !


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

3D printing is amazing technology! Thanks for the visit, Ingenira.


tammiejo67 profile image

tammiejo67 2 years ago from Illinois

The future of 3D printing in medicine is exciting. Thank you!


AliciaC profile image

AliciaC 2 years ago from British Columbia, Canada Author

Hi, tammiejo67. I agree - the medical applications of 3D printing are very exciting! Thanks for the comment.

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