As others, it depends on the type of vacation. Cruising is a great way to see many different locations, or it can be a totally relaxing vacation where the journey is the trip. Last May we took a positioning cruse from Miami to Barcelona with a stop in the Azors. The cruse was 10 days with no land for 7. I found this to be a wonderful vacation.
Anymore I hate flying as I feel it is so dehumanizing, I really resent the intrusions modern security requires all for an illusion of security. When I fly, I always will pay a couple dollars more for a direct flight as opposed to a connecting one, where not possible, I try and make the journey part of the trip as we did last year flying home from Barcelona. Found an Air Lingus flight from Barcelona to JFK through Dublin, so we spent the night. It was both more relaxing and quite an enjoyable stop over.