I can only draw on my personal experience.
My wife and I have four cats -- 2 boys and 2 girls. The girls are sisters and are about 5 years old now. The boys are brothers and are about 2.5 years old.
What I will say is that the girls have been harder to handle in some senses. They tend to be moodier and quicker to hiss and scratch. For instance, when the boys grow tired of being pet, they just get up and walk away (one of our boys though, Sherwood, doesn't ever seem to grow tired of this). But one of our girls, Juanita, sometimes will scratch us to let us know she's done, instead. Or when they run out the front door -- the boys tend to let us just pick them up and bring them back in, but the girls don't like that as much (the girls are also heftier) and we have to sort of corral them inside -- more on their own terms.
The girls are more territorial -- they carve out their space and really try to hold it down, and we try to respect that. The boys are more of the exploring type (I think this holds true in general) -- less territorial over areas at home, but more likely to try to get out and explore.
I should note that the girls were spayed fairly late -- they were going on 3 years old. The boys were neutered around 6 months or so. Generally, the boys are a bit more docile, but this may have something to do with it. An example of how this manifests itself -- when guests come over, especially strangers, they tend to see the boys as friendly and the girls as stand-offish. Which isn't how we see them, but I can understand the perception.
I will say that both the boys and the girls have gone through "spraying" phases. I once thought this was mostly for boys only, but the girls sprayed a good deal during their first 2-3 years. They don't do it anymore (as far as I know, anyway!). We still find a nice pee present from either of the boys from time to time!