Excluding cockroaches of course. It depends also if you are all alone or are protecting your pet or small child. For me, I freaked over a Gila Monster crawling from underneath my car and my little dog Chuggers was being curious. But that was because I was worried about my dog dying. For me alone - I did leap up & hovered in the air going six ways at the same time like a wacky cartoon when I woke up to a Arizona Giant Centipede that was 12 " from my hand
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First time I saw a camel spider I thought it was a mouse going vertically along my counter stand. (!!!)