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Proin Drug - Urinary Incontinence In dogs?

Updated on November 9, 2017

Is your dog taking Proin for urinary incontinence, if so read my visitors reviews

Article By Sharon Stajda

If you are currently giving your dog the drug Proin, please take time to read the candid reviews visitors have left here. After reading some of these reviews you may want to reconsider giving the drug Proin to your dog. Many visitors have claimed that they believe the drug attributed to their dog's untimely death. Proin is the number one drug used today to help dogs with urinary Incontinence. Is it safe? Well, some pet owner say no. In fact some dog owners believe that the drugs adverse side effects lead to the death of their dog.


Factors That Can Cause Urinary Incontinence In A Dog

There are many factors that can cause a dog to experience Urinary Incontinence.It is estimated that urethral incontinence may affect over twenty percent of all spayed female dogs, especially large-breed dogs. Urethral incontinence is most common in middle-aged to senior dogs, medium to large-breed female dogs. Although any dog may be affected. The main question, should your dog be treated with the drug Proin? Proin is the number one drug recommended by veterinarians to treat the problem of incontinence in dogs.

Wet Sleeping Area


A Tell Tale Sign That Your Dog May Be Incontinence

What is urethral incontinence? Urethral incontinence or urinary incontinence is the loss of voluntary control of urination. It's usually observed as involuntary leakage.

What are the clinical signs of urethral incontinence a dog will show? Number one a wet bed or sleeping area is one of the first sign you may discover. Many dog owners as their dog gets older, may start to find wet spots on their pets bed or on the floor where the pet has been laying down to sleeping. One might also spot dribbling of urine when the dog is walking. In most cases the dog will appear totally unaware of the urinary accident.

How Is Urethral Incontinence Diagnosed? - The best place to start, your dog should be taken to the Vet


What Causes Urethral Incontinence In A Dog? - There are actually several potential causes of urethral incontinence.


Does Your Dog Suffer From Urethral Incontinence?

Bladder storage dysfunction, including bladder hypercontractility. Bladder hypercontractility is when the bladder contracts to frequently, and causes small amounts of urine to leak.

Urethral incontinence in dogs can be caused by an underlying neurological problem. Neurological causes such as a spinal injury, disruption of nerves controlling the bladder, and brain disease or unidentified lesions.

Another culprit can be urinary infection. A urinary tract infection, bladder tumor or any condition that would compress the bladder or urinary tract can cause urethral incontinence in a dog.

Urethral disorders in which the muscles that close the urethra fail to tightly contract, and urine leakage occurs. This is one the more common causes, and is often associated with reproductive-hormone responsive urinary incontinence, urinary tract infection or inflammation, prostatic disease in male dogs, and vestibulo vaginal anomaly in female dogs.

Urethral incontinence in some cases can be attributed to anatomic abnormalities, such as a hereditary defect. Other factor's, injuries or surgery that caused damage or in some fashion altered the normal bladder of a dog.

Last of all urinary retention may result when a dog will not urinate due to stress. Fear or behavioral problems All of these factors can result in the bladder becoming badly distended, and in the end will cause urinary build up, and ultimately urinary leakage.

How Is Urethral Incontinence Treated? - Treatment will be based on your dog's specific diagnoses. Plus increased visits outside to void.


How Is Dog Urethral Incontinence Diagnosed?

Urethral Incontinence is most often diagnosed on clinical signs, medical history, and blood and urine tests. Bladder X-ray as well as ultrasounds are often done to search for bladder abnormalities, such as stones, tumor, and also any abnormalities that could be causing or affecting normal urine follow.

Neurological tests such as examination of the anal and tailbone, perineal sensation, and various spinal reflexes will be performed if a neurological disorder is suspected.

Urethral catheterization may be required if urinary retention is observed, to determine if there is an obstruction or other urethral abnormality present.

Treatments Of Urethral Incontinence

Medications that increase urethral sphincter tone , such as Phenylpropanolamine or hormone replacements, such as estrogen or diethylstilbestrol are most commonly used alone , and in combination. With long term usage, the dogs blood and urine should be periodically tested to ensure that there are no untoward side effects. Your veterinarian will prescribe the best treatment for your dog's individual needs.

Prognosis Depends On Severity

While the prognosis is determined by the specific cause, in general prognosis is good. Control of urine leakage will vary from dog to dog, however most dogs can be managed successfully with medication, lifestyle changes, such as more frequent trips outside to void, and close monitoring.

Cystoscopy may allow your vet to see an abnormality within the bladder or urethra.

I Treated My Dog With Proin For Her Incontinence Problem

My dog "Rose" became incontinent when she was seventeen. I tried everything to help her out with "her problem". My vet recommended the drug Proin as a last resort. You see Rose's incontinence was causing severe skin problems with urine scalding. I started Rose on Proin, and all seemed well, her accidents diminished, and her skin condition cleared. She was on the drug for about two months, and she developed seizures. The vet recommended we take Rose off of the Proin. In a matter of weeks "rose had a severe seizure, and was left immobile. She had to be put down. I felt lots of guilt for having used Proin on Rose. However, as the vet pointed out Rose was very up there in age, and he felt the seizure may have come with her advanced age

I am sorry that I used Proin for my dogs incontinence problem. I feel Proin added to the progression of my dogs health problems . Please be aware of the side effects of Proin, one of the side effects is stroke. Please read reviews at 'Guestbook, and please if you have used Proin to treat your dog's incontinence problem, add your comment.

Homeopathic Treatments For Treating Dog Incontinence

Please Read Visitors Reviews On The Drug Proin.

The drug Proin is the most commonly prescribed drug for dogs with urinary incontinence. Before you give the drug to your dog, please research, and check side effects that can occur with the drug Proin.

"Proin Seemed to speed her passing"

Liz wrote

"Our 5 Year old spaniel went downhill after taking Proin, she did have other medical conditions , but this seemed to speed her passing, within 7 days."

Boxer Fan Wrote ...

013 Feb 26, 2013 @ 6:30 pm

" Do NOT USE Proin ! Our 3 yr old boxer was placed on this drug a month ago (2 tablets per day, for spay incontinence).

Although the drug addressed the leaking problem it has our dog on the verge of death. The vet assured us there were NO side effects, except for possibly getting hyper. She stopped eating, drinking, is lethargic, heavy breathing, vomiting. The worst of the effects arose 3 days ago. Took her to the vet today and they suspect kidney failure. When she got home I researched Proin and was stunned on the amount of information (since 2009) that is on the internet warning of this drug. I have immediately stopped giving her Proin and can only hope I stopped administering it in time. As of now she's been off the drug for 24 hours and is chewing ice cubes and a very little food. She's lost 10 pounds in 30 days. I'll be back to update, good or bad, in a day or two. "


Boxerfan2013 Mar 1, 2013 @ 1:15 am

" Had to put the boxer down. 16 hours after I posted previously she still wouldn't eat or drink. The vet said treatment and hospitalization would not only be very expensive, but it may not resolve the problem.

This was a healthy dog who was administered Proin for spay incontinence. The vet believes the drug played no part in her failed health. Either he's an idiot or misdiagnosed the dog initially where the drug exacerbated a condition that he missed. It simply isn't worth the risk to your dog to use this drug. Had I researched the internet on Proin beforehand i would have tossed the bottle away. It may help some dogs, but it slowly and painfully killed mine. "

Please Take This Poll - Please read comments if your dog is taking Proin.

Have you used the drug Proin to curb your dogs incontinence, please leave a review on the drug. Your review is important, and might help a dog owner faced with the question - "Should I give my dog Proin?"

Have you ever used Proin to treat your dogs problem with Urinary Incontinence?

See results

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    • Sharlee01 profile image

      Sharon Stajda 2 weeks ago from Shelby Township Michigan

      Patricia, From the letters I have received over the years from pet owners in regards to Proin. It seems if the pet is going to have problems with the drug, it is immediate. It also seems the pet has some underlying health issues. It appears your dog has done well on the drug. Hopefully your friend gets well soon. I know how distressing it can be when your best friend is sick.

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      Patricia Webster 2 weeks ago

      I have been using PROIN for the past 3+ years with my Senior Rottweiler. I’ve not had any problem for the first 3 years, but about 6 weeks ago, she began vomiting, after either eating, or not. Took her to the Vet. Stats looked good. Fed her chicken and rice and took her off kibble because even when it was soaked she would still vomit. She still vomited but not as often. But, this last weekend, she has gone back to vomiting. Last night as I researched what causes vomiting in dogs - irritated stomach. So, went to bed pondering on what is causing the irritation in her tummy. She is on a thyroid pill and PROIN. That is why I am on this site because I haven’t ever really checked the side effects of this drug. She has lost weight, 10#. I am very glad to have checked this site as I am needing to renew this expensive drug, and if it is the cause of her problem then am very glad to discover it now before I spend the $45 for the small bottle of it. Thank you

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      Kelly 8 months ago

      My Golden was put on Proin for bladder issues. Less that 2 weeks later we woke to her unable to stand. Stomach bloated and in pain. We had to put her to sleep. She had a complete physical and blood work done prior to starting the Proin and she was absolutely fine. I totally blame proin for her death. DO NOT USE IT!

    • Sharlee01 profile image

      Sharon Stajda 17 months ago from Shelby Township Michigan

      I am so sorry you did not see this blog before you started your husky on Proin. My dog also was a victim, she died very shortly after taking the drug. She had kidney failure and seizures. had to also put her down....

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      Dezmcelheny 17 months ago


      My very healthy 10 year old female husky started leaking and the vet said Proin would fix it with no side affects except hyper and moody. Well, not even 4 months into the meds she had kidney failure and had to be put down! The worst effing day of my families life! Try telling your kids (ages 6&8) that their dog is dying and there's nothing we can do to help her!!

      There has to be another med out there or something to do to help them!! Anyone know of anything??

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      Mickey R 3 years ago

      My pug Bella was on Proin for three years. It worked beautifully for her. She died 11 months ago, completely unrelated to Proin (a necropsy was done, and Metacam was the problem). Her sister Maggie started taking Proin a month ago, and now acts like she is in pan all the time (stares at me a LOT, will not sit still very long, just doesn't seems herself). Taking her back to the vet to have BP checked and a panel, but her arthritis is quite advanced, so am not at all convinced Proin is to blame. Still, glad to have seen this page because I honestly had not considered Proin as a possible cause and was simply at the point of trying to determine if Maggie's arthritis has just made it to the stage where we cannot manage her pain anymore.

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      anggot 3 years ago

      Hi... My dog jada is a black lab. Not even two yet..has urine inconcintence.. A week ago I started her on proin.. Two nights in a row head seizures.. 2nd night was worse. Taking her off it tmrw.. Vet said that shouldn't be a cause. Well happened again.

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      hazelvin 3 years ago

      Much better than Euthanasia,

    • profile image

      michael-obrien-music 3 years ago

      I have been treating my 13-year-old labâpitbull mix with Proin for six months now. It has been her saving grace, as well as mine - because I no longer have to launder her dog bed on an almost, daily basis (sometimes multiple times a day) AND she no longer has to sleep in her own urine. I for one, am very thankful that my veterinarian recommended this medication for my dog. That being said, I think that the jury might still be out, on whether the benefits of Proin outweigh the potential side-effects IF your dog has abnormal levels in his/her blood panel/lab results. Therefore, I simply used my common sense. Before putting her on Proin, I had a complete blood panel done to make sure all of her levels were normal. Reason being, IF Proin is going to potentially harm a dog, it's likely going to be a dog that already had some sort of issue that comes naturally with old age, and had simply yet to be diagnosed. This seems to be the general consensus among those who actually know what they are talking about, and are worth listening to.

      Like any person who makes their decisions using research-based, scientific evidence (instead of one, anecdotal account of some pet owner's 10+ year old dog) I can't really take most of the "warnings" about Proin seriously. From all I have read, the paranoia comes mostly from pet owners who are failing to take countless other factors into consideration when blaming their Vet's recommendation of Proin on their dog's death. In fact, I have read some astonishingly stupid comments/assumptions made by people in this very thread. To say that "My 17 year old dog died shortly after being placed on Proin, so I blame Proin and my Vet" is really just a highly emotional and irrational conclusion reached by a grieving person who clearly does not understand that sometimes, a 17 year old dog just dies because he is 17 years old. I'm sorry to be so insensitive, but if you are going to have a dog on Proin, NSAID's or any other meds that come with potentially lethal side need to do a blood panel every six months. If your dog has issues with its kidneys, or digestive tract or high blood pressure etc - and you don't know this because you're medicating your dog without taking the necessary precautions...well then you cannot really blame your vet or the medication....because you just can't KNOW this, by any means.

      So here is where I stand. My dog (Gretyl) is 13. I am a mountaineer, and Gretyl has been with me, at every major peak I have summited in Southern California, since she was a pup. The vet described the results of her latest blood panel as "amazing" and "off the charts" for a 13 year old dog. I guess all that hiking throughout her life kept her very healthy, despite the toll it took on her poor hips. But even now, with the NSAID's, she can still manage stairwells and long walks without ANY problems...I just can't climb mountains with her anymore. SO - if Gretyl suddenly strokes out, or has her kidneys fail - or anything along these lines, then I might have reason to be suspicious of Proin.

      OR - If anyone else out there can attest to have a perfectly healthy dog (proven by a blood panel, not just assumed, because you "see" nothing wrong) who succumbed to something terrible soon after being put on Proin - then again, I'd have reason to be suspicious. But I have yet to see ANY compelling evidence that makes me feel like I need to worry, beyond making sure her levels remain normal, by doing a panel every 6 months.

      My two cents...happy dog days people :)

    • profile image

      dhmsuzyqangel 4 years ago


    • profile image

      dennismcmahen 4 years ago

      Our Sammie has been on Proin since shes been 4 months old, she is now 10 years old.

      Sammie developed seizure disorder when she turned 6 years old. No tumor, no head trauma.

      She has seizures every 4/5 weeks.I believe that I'm going to try to wean her down off of Proin to see if her seizure pattern changes. Any comments will be appreciated.

    • profile image

      anonymous 4 years ago

      My four-year old Lab Mix has been on Proin for a couple of weeks. The first day I gave her three tablets and it really knocked her out. Now I give her one in the morning and one in the evening and her behavior and eating habits have been fine. She's playful and has a great appetite. The incontinence has stopped. The one thing that I have noticed that's concerning is that there are some red spots that have shown up in the brown parts of her eyes. And her eyes seem more bloodshot in the white area. I haven't spoken to the vet yet. He told me to give her three for awhile, then down to two and then to one. I immediately went to two because of the lethargy at three tablets, but I may keep her on two for a few more days and then go to one and see how we do. I haven't seen any of the bad side effects that I've read about, but that doesn't mean it couldn't happen. I'm just going to stay very aware and watch her.

    • profile image

      anonymous 4 years ago

      I have a female German Shepherd mix 4yrs old who has just started having incontinence problems while she sleeps. My vet tested her urine for infection but it came back clean so she prescribed Proin, 75mg 1/2 tablet twice a day. This morning I gave my dog 1/2 tablet with her food, 3hrs later she threw up (which is very unusual for this dog). After researching Proin on the Web and reading about the side effects I'm going to return the remaining pills and talk to the vet about another solution.

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      anonymous 4 years ago

      My 5 year old Newfoundland was given Proin. She became lethargic, wouldn't eat and her stools were very dark. The day after I stopped giving her this drug, she started to eat again and she is playing with her toys and she has life back in her eyes. I was never told of any side effects to this drug. I hope this has not caused her any damage.

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      anonymous 4 years ago

      My 5yr old min poodle has been having incontinence issues when she sleeps. Started her on Proin last Tuesday. She was tested for an uti but was clear. She started refusing to eat, had dark runny stools, started vomiting yellowish bile. Lethargic, and just doesn't feel like her usual self. Am taking her off the drug immediately.

    • profile image

      anonymous 5 years ago

      I think there comes a time in a dog's life whereby almost NO medicine should be given. I am totally being dramatic because I have a 14 year old and I have read so much about medicines being bad for this that or the other. After reading this...I am going to keep the diapers on her. I don't want to even take a chance. I cannot afford to have her heart looked at to see if she could even handle any medicine. Thanks so much for posting.

    • Sharlee01 profile image

      Sharon Stajda 7 years ago from Shelby Township Michigan

      I am sad to post that I used Proin for my dogs incontinence problem. "Rose" was 16, and having a real problem with incontinence. She actually would void in her sleep, which caused a severe skin scolding. I had little choice but to try Proin. I tried every alternative. Rose had a stroke about two months of starting Proin, and passed on. I have to believe her age and weak condition caused the stroke, and ultimate death. However, I will never be sure if Proin aided the progression of the stroke. Please be aware of the side effect's of Proin, one of the side effect's is stroke.

    • profile image

      anonymous 7 years ago

      My 16 year old westie was having problems with incontinence. She would wet where ever she fell asleep, day and night. The problem was getting severe. The vet put her on Proin. the dose was 12.5 mg 3 times a day. From the first dose the accidents stopped. However, the second day after she began her treatment, she became very agitated panting, and not being able to rest.

      I cut the dose in half, and saw no improvement in her agitation. She still had no problems with inconstancy. I was about to give up... I again cut the dose to 3.12, 1/8 of a 25 mg tab. This small dose worked, no more accidents, no more agitation. I suggest that if one chooses to use Proin, start at a low dose, and increase if needed.

    • Sharlee01 profile image

      Sharon Stajda 8 years ago from Shelby Township Michigan

      My dog is starting to have problems with urinary incontinence. She is 16, and her vet checked her out, and claims it's her age... It seems to help by limiting her water after 7pm.

      and getting her out to void every 3 waking hours. Any tips would be appreciated.