If you want to do the whole large quilt by hand, you can roll and use the tube clamps that you use to machine quilt, or you can lap quilt sections and then sew the sections together, there are many small block quilt frames available even up to 18 and 24 inch square to do a section at a time-similar to a crewel work hoop. Some wood hoops on stands come up to 36" if you don't have a lot of space.
Here are 2 links on building different quilt frames. I had one years ago that an amish community made. I no longer have big items.