Depends on what you want. For lightfastness I recommend Pitt Artist Pens brush tip, and intend to get some of the more expensive Pitt Big Brush ones for doing larger art and coloring comics art if I ever finish that graphic novel (which is looking doubtful). But I care about lightfastness.
If you're doing something where the scan or print is the lasting original, say, graphic novel art where you're not going to frame and sell pages as individual artworks, then Prismacolor double tip markers are the ones I've used and they're good. Nice big range of colors, handle well, pretty good. Some swear by Copic but they are expensive and I haven't tried them.
Based on past experience with other Dick Blick house brand products, if I do get a full range set of markers it'll probably be Blick Artists Markers, come in a range of 96 colors with a chisel and fine point tip like the Prismacolor ones and are distinctly less expensive.
If you want watersoluble, Tombow brush pens rock! I use those for all my notans, they are more expressive than chisel tip markers but can still be used to fill large areas. They can be shaded with water for a "sketch and wash" effect and so the darker colors become versatile as wash colors just the way they are in watercolor pencils. Been meaning to get some sets of those too, other than just the black and grays I use for notans.
For actual pens, Sakura Pigma Micron rules as the best disposable technical pen I've ever tried. Prismacolor Archival Markers come in colors and are waterproof too, a similar product, but don't last as long. I bought a set of Pigma Microns and a set of Prismacolor ones at the same time. A couple of Prismacolor brown ones have dried out, I had to replace the black already, but all six Microns are still going strong. Also, Blick now carries the color Pigma Micron ones including a set of 16 colors in size 05 (pretty big line) and also now has 1mm, 2mm and 3mm points in black and sepia for filling-in big spaces.