I would pick up a certified used Honda Accord Hybrid. It is spacious, comfortable, powerful, and still highly efficient. It comes standard with leather and navigation (if you're into that kind of stuff), so it is not lacking in any respect. It has better weight and ground clearance than the more notable Toyota Prius, and I just like the way it looks, too.
I would buy one used, because new they retail at over $30,000.
Hope this helps.
I think what is important when buying any hybrid is understanding what you need in the environment you live in. If I lived somewhere where 4wd was necessary -- or even of aid -- I'd grab a Toyota Highlander Hybrid. If I was the kind of person who needed to be noticed, I'd get a Cadillac Escalade Hybrid (yes, they really do make them). If fuel economy was far and beyond the most crucial thing, I'd stick with the good old Prius. But if you're looking for a nice combo number, check out the Honda Accord, Toyota Camry, or maybe Ford Escape Hybrids.