Pay off my debts. Invest so I had a monthly income for life (reasonable amount). Pay off children's student loans. Then, once I knew I was fine as far as taxes went I would donate. I need to get caught up on my donations to church, there is a battered women's shelter here I would like to donate to, and I would donate to the American Cancer Society as I have lost some cherished friends.
I would donate to a couple friends student loans as they have been strong supporters of me and all my efforts over the past 10 years. Next, I would consider setting a school with employment assistance for all middle aged adults who are out of work. I know all the problems associated with being middle aged trying to get jobs when most employers overlook you for younger people.
Anything left I would then donate to other charities working with homeless, underprivileged, seniors, and then the school systems. In short I would take care of myself without going overboard and then use the balance to try to make a difference in my children's, a few friends and the rest of the world.